Yazar "Osmaniye, Derya" için listeleme
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Synthesis and monoamine oxidase A/B inhibitory evaluation of new benzothiazole-thiazolylhydrazine derivatives
Turan, Gulhan; Osmaniye, Derya; Saglik, Begum Nurpelin; Cevik, Ulviye Acar; Levent, Serkan; Cavusoglu, Betul Kaya; Kaplancikli, Zafer Asim (Taylor & Francis Ltd, 2020)In this study, a novel series of benzothiazole-thiazolylhydrazine (3a-3i) was synthesized and their structures were characterized by H-1-NMR, C-13-NMR spectrometry, and mass spectroscopy. These compounds were evaluated as ... -
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
Osmaniye, Derya; Levent, Serkan; Karaduman, Abdullah Burak; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at ... -
Synthesis of new benzothiazole derivatives bearing thiadiazole as monoamine oxidase inhibitors
Acar Cevik, Ulviye; Osmaniye, Derya; Saglik, Begum N.; Levent, Serkan; K. Cavusoglu, Betul; Karaduman, Abdullah B.; Turan, Gulhan (Wiley, 2020)Monoamine oxidases (MAO) are enzymes that catalyze the oxidative deamination of monoamines such as dopamine, noradrenaline, adrenaline, and serotonin. Recent studies have shown that numerous benzothiazole derivatives exhibit ... -
Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
Can, Nafiz Öncü; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; İnci, Beril; Ilgın, Sinem; Kaplancıklı, Zafer Asım (MDPI, 2017)In the present work, 14 new 1-substituted-2-phenylhydrazone derivatives were synthesized to evaluate their inhibitory activity against hMAO enzymes. The structures of the newly synthesized hydrazones 2a-2n were characterized ... -
Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
TokgÖz, Gamze; Özkay, Ümide Demir; Osmaniye, Derya; Yücel, Nazlı Turan; Can, Özgür Devrim; Kaplancıklı, Zafer Asım (MDPI, 2018)Novel benzazole derivative compounds 4a-4h were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds ... -
Synthesis of novel benzimidazole-oxadiazole derivatives as potent anticancer activity
Cevik, Ulviye Acar; Osmaniye, Derya; Cavusoglu, Betul Kaya; Saglik, Begum Nurpelin; Levent, Serkan; Ilgin, Sinem; Kaplancikli, Zafer Asim (Springer Birkhauser, 2019)DNA topoisomerase I regulates DNA topological structure in many cellular metabolic processes and is a validated target for the development of antitumor agents. in this work, a series of novel 2-[(5-(4-(5(6)-substituted-1 ... -
Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
Levent, Serkan; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI AG, 2017)In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel ... -
Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities
Can, Nafiz Öncü; Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir (MDPI, 2018)Novel thiadiazole derivatives were synthesized through the reaction of acetylated 2-aminothiadiazole and piperazine derivatives. The chemical structures of the compounds were clarified by Infrared Spectroscopy (IR), H-1 ... -
Synthesis, biological activity evaluation and molecular docking studies of novel thiazole derivatives
Uğur, Kayiş; Gül, Ülküye Dudu (Anadolu Üniversitesi, 2023)Resistance to existing drugs develops because of insensible use of antibacterial and antifungal drugs. Therefore, there is a need for the development of new drug candidate compounds. The thiazole ring has many biological ... -
Synthesis, characterization and carbonic anhydrase I and II inhibitory evaluation of new sulfonamide derivatives bearing dithiocarbamate
Saglik, Begum Nurpelin; Osmaniye, Derya; Cevik, Ulviye Acar; Levent, Serkan; Cavusoglu, Betul Kaya; Buyukemir, Oya; Kaplancikli, Zafer Asim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2020)In this study, novel dithiocarbamate-sulfonamide derivatives (3a-3k) were synthesized to investigate their inhibitory activity on purified human carbonic anhydrase (hCA) I and II. the IC50 and Ki values of the compounds ... -
Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor
Cevik, Ulviye Acar; Cavusoglu, Betuel Kaya; Saglik, Beguem Nurpelin; Osmaniye, Derya; Levent, Serkan; Ilgin, Sinem; Kaplancikli, Zafer Asim (Mdpi, 2020)In the last step of estrogen biosynthesis, aromatase enzyme catalyzes the conversion of androgens to estrogens. Aromatase inhibition is an important way to control estrogen-related diseases and estrogen levels. in this ... -
Synthesis, molecular docking analysis and carbonic anhydrase I-II inhibitory evaluation of new sulfonamide derivatives
Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Osmaniye, Derya; Levent, Serkan; Kaya Çavuşoğlu, Betül; Demir, Y. (NLM (Medline), 2019)New sulfonamide-hydrazone derivatives (3a-3n) were synthesized to evaluate their inhibitory effects on purified human carbonic anhydrase (hCA) I and II. The inhibition profiles of the synthesized compounds on hCA I-II ... -
Yeni kinaz inhibitörlerinin tasarımı, sentezi ve biyolojik aktivite çalışmaları
Kaplancıklı, Zafer Asım; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü; Osmaniye, Derya (Anadolu Üniversitesi -Sağlık Bilimleri Enstitüsü, 2021)Kanser hastalığı multifaktöriyel etkenli bir rahatsızlık olduğu için birçok sebebi bulunmaktadır. Dünya Sağlık Örgütü raporuna göre kanser, yalnızca 2018'de tahmini 9.6 milyon ölümle dünya çapında kardiyovasküler hastalıklardan ...