Yazar "Çiftçi, Gülsen Akalın" için listeleme
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Synthesis and Biological Evaluation of a New Series of Pyrazolines as New Anticandidal Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Çiftçi, Gülsen Akalın; Demirci, Fatih (Springer, 2014)New pyrazoline derivatives bearing an oxadiazole moiety were synthesized via the reaction of 1-(chloroacetyl)-3-(2-furyl/thienyl)-5-aryl-2-pyrazolines with 5-substituted-1,3,4-oxadiazole-2(3H)-thiones in the presence of ... -
Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors
Yurttaş, Leyla; Kaya Çavuşoğlu, Betül; Çiftçi, Gülsen Akalın; Temel, Halide Edip (Bentham Science Publ LTD, 2018)Background: 1,3,4-Oxadiazoles have been known with a wide variety of pharmacological activities including anticancer activity. Objective: In this study, novel 2,5-disubstituted 1,3,4-oxadiazole derivatives were synthesized ... -
Synthesis and Biological Evaluation of Some 1,2-Disubstituted Benzimidazole Derivatives as New Potential Anticancer Agents
Yurttaş, Leyla; Demirayak, Şeref; Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar; Kaplancıklı, Zafer Asım (Wiley-V C H Verlag GMBH, 2013)The synthesis of some new 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives and investigation of their anticancer activities were the aims of this work. 2-(Chloromethyl)benzimidazole compound ... -
Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Turan, Gülhan; İşcan, Gökalp; Çiftçi, Gülsen Akalın (Bentham Science Publ LTD, 2013)In this study, N-(benzothiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives (1-24) were obtained by the reaction of 2-chloro-N-(benzothiazole-2-yl)acetamides with piperidine derivatives. The structures of the compounds ... -
Synthesis and biological evaluation of some new pyrimidine bearing 2,5-disubstituted 1,3,4-oxadiazole derivatives as cytotoxic agents
Kaya, Betül; Kaplancıklı, Zafer Asım; Yurttaş, Leyla; Çiftçi, Gülsen Akalın (Walter De Gruyter GMBH, 2017)Objective: As a result of adverse effects including drug-resistance, toxicity and low bioavailability, there has been a crucial need for novel anticancer agents. In this present study, some novel 2,5-disubstituted ... -
Synthesis and Biological Evaluation of Some Pyrazoline Derivatives Bearing a Dithiocarbamate Moiety as New Cholinesterase Inhibitors
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Turan, Gülhan; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Wiley-V C H Verlag GMBH, 2013)In the present study, new pyrazoline derivatives were synthesized via the reaction of 1-(chloroacetyl)-3-(2-furyl)-5-aryl-2-pyrazolines with sodium salts of N,N-disubstituted dithiocarbamic acids. Each derivative was ... -
Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors
Turan, Gülhan; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Informa Healthcare, 2013)In the present study, some thiazole derivatives were synthesized via the ring closure reaction of 1-[2-(2-oxobenzo[d] thiazol-3(2H)-yl)acetyl]thiosemicarbazide with various phenacyl bromides. The chemical structures of the ... -
Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Çiftçi, Gülsen Akalın; Demirel, Rasime (Elsevier France-Editions Scientifiques Medicales Elsevier, 2014)N'-(3,4-Diarylthiazol-2(3H)-ylidene)-2-(arylthio)acetohydrazides were synthesized and evaluated for their antimicrobial activity and cytotoxicity against NIH/3T3 cells. Compound 22 bearing 1-phenyl-1H-tetrazole and ... -
Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents
Özdemir, Ahmet; gökbulut, Sevtem; Sever, Belgin; Çiftçi, Gülsen Akalın; Altıntop, Mehlika Dilek (Bentham Science Publ LTD, 2018)Background: Arylidene indanones have attracted a great deal of interest due to their outstanding therapeutic applications. In particular, considerable research has pointed out the importance of arylidene indanones in the ... -
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Çiftçi, Gülsen Akalın; Temel, Halide Edip (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New bis-thiazole derivatives (1-10) were synthesized via the ring closure of 1,1'-(3,3'-dimethoxybipheny1-4,4'-diyl)bis(thiourea) with phenacyl bromides and evaluated for their cytotoxic effects on A549 human lung ... -
Synthesis and evaluation of new benzodioxole-based dithiocarbamate derivatives as potential anticancer agents and hCA-I and hCA-II inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Küçükoğlu, Kaan; Özdemir, Ahmet; Soleimani, Seyedeh Sara; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the current work, new benzodioxole-based dithiocarbamate derivatives were synthesized via the reaction of N-(1,3-benzodioxol-5-ylmethyl)-2-chloroacetamide with appropriate sodium salts of N,N-disubstituted dithiocarbamic ... -
Synthesis and Evaluation of New Benzodioxole-Based Thiosemicarbazone Derivatives as Potential Antitumor Agents
Altıntop, Mehlika Dilek; Temel, Halide Edip; Sever, Belgin; Çiftçi, Gülsen Akalın; Kaplancıklı, Zafer Asım (MDPI, 2016)New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cells. In order to ... -
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Turan, Gülhan; Çiftçi, Gülsen Akalın; Ertorun, İpek; Alataş, Özkan; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the present work, new indole-based chalcone derivatives were obtained via the reaction of 5-substituted-1H-indole-3-carboxaldehydes/1-methylindole-3-carboxaldehyde with appropriate acetophenones. The synthesized compounds ... -
Synthesis and In vitro Evaluation of Thiadiazole Derivatives as AChE, BuChE and LOX Inhibitors
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Abu Mohsen, Usama; Temel, Halide Edip; Çiftçi, Gülsen Akalın; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2014)N'-Benzylidene-2-[[5-(phenylamino)-1,3,4-thiadiazol-2-yl]thio]acetohydrazide derivatives (5a-p) were synthesized to screen for their AChE, BuChE and LOX inhibitory activity. The CCK-8 assay was also carried out to determine ... -
Synthesis of 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and evaluation of their anticancer activity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar (Informa Healthcare, 2013)In the present study, 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives (1-6) were synthesized via the ring closure reaction of 1-(2-thienyl)-3-aryl-2-propen-1-ones with hydrazine hydrate in acetic acid. The chemical ... -
Synthesis of novel 3, 5, 6-trisubstituted triazine derivatives and their biological activity evaluation as potential antitumor and anti-inflammatory agents
Yurttaş, Leyla; Şahin, Z.; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Demirayak, Şeref (University of Istanbul, 2016)In this study, new 3, 5, 6-trisubstituted 1, 2, 4-triazine derivatives (1-9) were synthesized and their structures were determined by using NMR, IR and Mass spectroscopic methods. In vitro antitumor activities against MCF-7 ...