Yazar "Ak, Dilek" için listeleme
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The protective effect of vasoactive intestinal peptide (VIP) on stress-induced gastric ulceration in rats
Tunçel, N.; Erkasap, N.; Şahintürk, V.; Ak, Dilek; Tunçel, Muzaffer (New York Academy of Sciences, 1998)The pathogenesis of cold restraint stress ulcer involves various factors and is not completely understood. Mast cell degranulation, increased gastric muscular contractility, diminished mucosal blood flow, release of several ... -
Protective effect of vasoactive intestinal peptide on testicular torsion-detorsion injury: Association with heparin-containing mast cells
Can, C; Töre, F; Tuncel, N; Uysal, Oktay; Gürer, G; Ak, Dilek; Tuncel, M (Elsevier Science Inc, 2004)Objectives. To elucidate the action of vasoactive intestinal peptide (VIP) on detorsion injury and the heterogeneity of mast cells in the testes of rats. Methods. Prepubertal male Sprague-Dawley rats were used in six groups. ... -
Retention Behaviour of Bupropion Hydrochloride in Reversed Phase Ion Pair LC and Validated Analysis of the Drug in Pharmaceuticals
Yeniceli, Duygu; Ak, Dilek (Springer Heidelberg, 2010)The chromatographic behaviour of bupropion hydrochloride, a basic drug of pK (a) 7.9, has been investigated under reversed-phase ion-pairing conditions and the results were used to develop a method for analysis of bupropion ... -
A simple and sensitive LC-ESI-MS (ion trap) method for the determination of bupropion and its major metabolite, hydroxybupropion in rat plasma and brain microdialysates
Yeniceli, Duygu; Şener, Erol; Korkmaz, Orhan Tansel; Ak, Dilek; Tuncel, Neşe (Elsevier Science BV, 2011)A specific and highly sensitive liquid chromatography-electrospray mass spectrometry (LC-ESI-MS) method for the direct determination of bupropion (BUP) and its main metabolite hydroxybupropion (HBUP) in rat plasma and brain ... -
A Simple and Specific Hplc Method for the Determination of Atomoxetine in Pharmaceuticals and Human Plasma
Ak, Dilek; Yeniceli, Duygu (Taylor & Francis Inc, 2010)A liquid chromatographic method has been described for the determination of atomoxetine in pharmaceuticals and human plasma. Plasma samples were analyzed after a simple, one step protein precipitation with methanol, and ... -
Simultaneous Determination of Substance P and CGRP in Rat Brainstem Tissue Using LC-ESI-MS/MS Method
Alasag, Neva; Şener, Erol; Ak, Dilek (Bentham Science Publ LTD, 2018)Background: Substance P and CGRP are neuropeptides that belong to the thachykinin and calcitonin family, respectively. They play an important role in neuropathic pain development and regulation. Methods: In this study, ... -
A Study on the Polarographic-Behavior and Determination of Tizanidine
Tunçel, Muzaffer; Ak, Dilek (Marcel Dekker Inc, 1992)The direct current polarographic behaviour of tizanidine based on the reduction of the molecule on the surface of DME is described and the optimum polarographic conditions for the determination are presented in this study. ... -
TLC densitometric determination of omeprazole in pharmaceutical preparations
Ak, Dilek; Tunalıer, Zeynep; Tunçel, Muzaffer (Govi-Verlag GMBH, 1998)… -
Validated analysis of fluvastatin in a pharmaceutical capsule formulation and serum by capillary electrophoresis
The capillary electrophoretic behavior and the determination of fluvastatin (FLU) in capsule and serum is described in this study. Method development was conducted in a fused-silica capillary (L = 86 cm, Leff = 58 cm and ... -
A validated HPLC method with fluorescence detection for the determination of droperidol in pharmaceutical tablets, human serum, and human milk
Yeniceli, Duygu; Ak, Dilek; Tunçel, Muzaffer (Springer Heidelberg, 2007)A sensitive and simple HPLC method with fluorimetric detection has been developed for determination of droperidol in pharmaceutical tablets, human serum, and human milk. Chromatography was performed on a 100 mm x 3 mm i.d. ... -
Validated Method for the Determination of Piroxicam by Capillary Zone Electrophoresis and Its Application to Tablets
Dal, Arın Gül; Oktayer, Zeynep; Ak, Dilek (Hindawi Publishing Corporation, 2014)Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination of piroxicam in tablets. The separation of piroxicam was conducted in a fused-silica capillary by using ... -
A Validated Thin-Layer Chromatographic Method for Analysis of Bupropion Hydrochloride in a Pharmaceutical Dosage Form
Yeniceli, Duygu; Ak, Dilek (Akademiai Kiado Zrt, 2010)A simple and sensitive thin-layer chromatographic method has been established for analysis of bupropion hydrochloride in pharmaceutical tablets. Chromatography on silica gel 60 F-254 plates with 30:10:1 (v/v) ethanol ... -
Vasoactive intestinal peptide inhibits degranulation and changes granular content of mast cells: A potential therapeutic strategy in controlling septic shock
Tunçel, N.; Töre, Fatma; Şahintürk, V.; Ak, Dilek; Tunçel, Muzaffer (2000)Vasoactive intestinal peptide (VIP) has potent protective activity against sepsis and increases the survival rate of septic rats and mice. The present study was planned to evaluate the effect of VIP on mast cell activity, ... -
Voltammetry of trazodone by platinum electrode and its determination in tablets using DP technique in the rotating conditions
Ak, Dilek; Zaimoğlu, V.; Tunçel, Muzaffer (1999)The voltammetric behaviors of trazodone using a platinum electrode in stationary or rotating conditions and its determination in tablets by DP rotating electrodes are described in this study. The experiments were conducted ...