Yazar "Altıntop, Mehlika Dilek" için listeleme
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In silico Molecular Docking and ADME Studies of 1 3,4-Thiadiazole Derivatives in Relation to in vitro PON1 Activity
Sever, Belgin; Küçükoğlu, Kaan; Nadaroğlu, Hayrunnisa; Altıntop, Mehlika Dilek (Bentham Science Publ LTD, 2019)Background: Paraoxonase 1 (PON1) is a paraoxonase, arylesterase and lactonase associated with protection of lipoproteins and cell membranes against oxidative modification. Objective: Based on antioxidative properties of ... -
Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies
Sever, Belgin; Altıntop, Mehlika Dilek; Kuş, Gökhan; Özkurt, Mete; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)In the current work, new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives (1-8) were synthesized via the ring closure reaction of 2-bromoacetophenone derivatives with 4-amino-5-[(5-methoxy-2-methyl-1(4-chlorobenzoyl)- ... -
Induction of apoptosis in lung adenocarcinoma and glioma cells by some oxadiazole derivatives
Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım (Springer Birkhauser, 2014)Oxadiazoles have received much attention due to their wide range of biological activities including antitumor activity. In this study, we aimed to study apoptotic effects of some 1,3,4-oxadiazole derivatives on human lung ... -
Investigation of the inhibitory effects of isoindoline-1,3-dion derivatives on hCA-I and hCA-II enzyme activities
Nadaroğlu, H.; Güngör, A. A.; Gündoğdu, Ö.; Kishali, N. H.; Sever, Belgin; Altıntop, Mehlika Dilek (Elsevier B.V., 2019)Inhibition of carbonic anhydrase (CA) has emerged as a promising approach for the treatment of a variety of diseases such as glaucoma, epilepsy, obesity and cancer. As a result, the design of CA inhibitors (CAIs) is an ... -
A mini-survey on vitamin usage habits in eskİşehİr [Eskişehir'de vitamin kullamm ahskanhklari{dotless} üzerine dar kapsamh bir araşti{dotless}rma]
In the present study, vitamin usage habits of five hundred people representing four different socio-cultural groups in Eskişehir and the factors affecting these habits were studied. The participants of the research were ... -
New Benzodioxole-based Pyrazoline Derivatives: Synthesis and Anticandidal, In silico ADME, Molecular Docking Studies
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek (Bentham Science Publ LTD, 2019)Background: Azoles are commonly used in the treatment and prevention of fungal infections. They suppress fungal growth by acting on the heme group of lanosterol 14 alpha-demethylase enzyme (CYP51), thus blocking the ... -
New pyrazoline derivatives and their antidepressant activity
Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Altıntop, Mehlika Dilek; Can, Özgür Devrim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental ... -
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve (MDPI AG, 2017)In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with ... -
Novel Naphthyridine-Hydrazone Derivatives and their Antimicrobial Activity
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Demirci, Fatih; Mohsen, Abu Usama; Kaplancıklı, Zafer Asım (2014)Amaç: Bu çalışmada, on yeni Naftiridin-Hidrazon türevinin sentezi ve antimikrobiyal aktivitelerinin değerlendirilmesi amaçlanmıştır. Materyal ve Metod: Sentezlenen bileşiklerin yapıları 1H-NMR ve MS spectral verileri ile ... -
A novel series of thiazolyl-pyrazoline derivatives: Synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirel, Rasime; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the current work, new thiazolyl pyrazoline derivatives (1-22) were synthesized and evaluated for their antifungal effects against pathogenic yeasts and molds using a broth microdilution assay. Ames assay was carried out ... -
Potential inhibitors of human carbonic anhydrase isozymes I and II: Design, synthesis and docking studies of new 1,3,4-thiadiazole derivatives
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Küçükoğlu, Kaan; Onem, Hicran; Nadaroğlu, Hayrunnisa; Kaplancıklı, Zafer Asım (Pergamon-Elsevier Science LTD, 2017)In the last years, inhibition of carbonic anhydrase (CA) has emerged as a promising approach for pharmacologic intervention in a variety of disorders such as glaucoma, epilepsy, obesity, and cancer. As a consequence, the ... -
A Survey about Pharmacy Technicians in Eskisehir
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin (Çukurova University, Fac Medicine, 2015)Purpose: In the current work, we aimed to carry out a research on the evaluation of pharmacy technicians from the perspective of pharmacists in Eskisehir. Material and Methods: The pharmacists of this test were chosen by ... -
Synthesis and analgesic activity of some acetamide derivatives
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Turan, Gülhan; Özdemir, Ahmet; Can, Özgür Devrim (Informa Healthcare, 2012)In the present study, some acetamide derivatives were synthesized and their potential analgesic activities were investigated. N-(benzothiazol-2-yl)-2-[(1-substituted-1H-tetrazol-5-yl) thio] acetamide derivatives were ... -
Synthesis and anticandidal activity of new triazolothiadiazine derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; İşcan, Gökalp; Akalın Çiftçi, Gülsen; Yıldırım, Şafak Ulusoylar (Elsevier France-Editions Scientifiques Medicales Elsevier, 2011)New triazolothiadiazine derivatives were synthesized via the ring closure reaction of 4-amino-5-substituted-2,4-dihydro-3H-1,2,4-triazol-3-thiones with phenacyl bromides. The compounds were tested in vitro against various ... -
Synthesis and Anticholinesterase Activity and Cytotoxicity of Novel Amide Derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Temel, Halide Edip; Akalın Çiftçi, Gülsen (Wiley-V C H Verlag GMBH, 2012)In the present study, some amide derivatives were synthesized and their potential anticholinesterase properties were investigated. N-(Benzothiazol-2-yl)-2-[(5-amino/methyl-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives ... -
Synthesis and antifungal activity of new heterocyclic compounds
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Turan, Gülhan Zitoun; Özdemir, Ahmet; Demirel, Rasime; Mohsen, Abu Usama (2013)Amaç: Bu çalışmanın amacı, heterosiklik bileşik olarak, 2-ariltiyo-N-(2-metoksidibenzo[b,d]furan-3-il)asetamid türevlerinin sentezleri ve mantar türlerine karşı etkilerini araştırmaktır. Yöntem: 2-Kloro-N-(2-metoksidiben ... -
Synthesis and antifungal activity of new hydrazide derivatives
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Demirci, Fatih; Abu Mohsen, Usama; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2013)In this study, nine new hydrazide derivatives were synthesized. The reaction of 2-[(5,6,7,8-tetrahydronaphthalen-2-yl) oxy]acetohydrazide with various benzaldehydes or acetophenones resulted in N'-substituted-2-[(5,6,7,8 ... -
Synthesis and antimicrobial activity of benzimidazole-based acetamide derivatives
Altıntop, Mehlika Dilek; Abu Mohsen, Usama; Özkay, Yusuf; Demirel, Rasime; Kaplancıklı, Zafer Asım (Turkish Pharmacists Association, 2015)In the current work, new benzimidazole-based acetamide derivatives (2a-u) were synthesized and screened for their in vitro antimicrobial activity. Among these derivatives, compounds 2b-2g were found to be the most promising ... -
Synthesis and Antimicrobial Activity of Benzimidazole-Based Acetamide Derivatives
Altıntop, Mehlika Dilek; Mohsen, Abu Usama; Özkay, Yusuf; Demirel, Rasime; Kaplancıklı, Zafer Asım (2015)Bu çalışmada, yeni benzimidazol taşıyan asetamit türevleri (2a-u) sentezlendi ve in vitro antimikrobiyal etkileri için tarandı. Bu türevler arasında, 2b-2g bileşikleri Pseudomonas aeruginosa'ya karşı en ümit verici ... -
Synthesis and Antimicrobial Activity of New Pyrazoline Derivatives
Özdemir, Ahmet; Turan, Gülhan; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Demirci, Fatih (Elsevier Science BV, 2011)…
