Yazar "Seller, Zerrin" için listeleme
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Determination of Phenolic Compounds, Cytotoxic, Antioxidant and Anticandidal Effects of Tribulus Terrestris L. (Zygophyllaceae)
Küçük, Sevim; Göğer, Fatih; İşcan, Gökalp; Özdemir, Filiz; Kırımer, Neşe; Seller, Zerrin (Parlar Scientific Publications (PSP), 2017)This study was investigated the potential cytotoxic, antioxidant and anticandidal activities of T terrestris in vitro. Both the fruit and aerial parts of the T terrestris extract showed a significant cytotoxic effects in ... -
Direct and protective effects of single or combined addition of vincristine and epsilon-viniferin on human HepG2 cellular oxidative stress markers in vitro
Tarhan, Seda; Özdemir, Filiz; Seller, Zerrin; Demirkan, Emine Sutken (Springer, 2016)The objective of this study is to examine the direct effects of low doses and high doses of epsilon-viniferin, a substance known to be an antioxidant, and vincristine sulphate, a chemotherapeutic agent, alone and in ... -
The effects of 1,3 bis (heteroaryl substitued) benzene derivatives on apoptosis of N-ras transformed mouse skeletal muscle cell [1,3-Bi·s (heteroari·l sübsti·tüe) benzen türevleri·ni·n N-ras transform fare kasi hücre apoptozu üzeri·ne etki·leri·]
Akalın Çiftçi, Gülsen; Seller, Zerrin (2005)Increasing number of the cells, results of excess divicing of the cells, is balanced by apoptosis which causes elimination of old cells and unfunctional cells. Apoptosis is a programmed cell death obtaining this balance. ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines
Akalın Çiftçi, Gülsen; Seller, Zerrin (2011)Fenolik bir monoterpen olan karvakrol kekik bitkisinde bulunmaktadır ve besinlerde baharat olarak kullanılmaktadır. Bu çalışmanın amacı, karvakrol’ün H-ras transform edilmiş 5RP7 ve N-ras transform edilmiş CO25 hücreleri ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines [Karvakrol'ün H-ras ve N-ras transform hücre apoptozu üzerine etkileri]
Akalın Çiftçi, Gülsen; Seller, Zerrin (2011)Carvacrol is a phenolic monoterpen found in Thyme plant which is used as a source of flavour in food. The aim of this study was to investigate apoptotic effects of carvacrol on H-ras transformed 5RP7 and N-ras transformed ... -
Effects of fibronectin and type IV collagen on osteosarcoma cell apoptosis
Seller, Zerrin; Hatipoğlu, İbrahim; Sivas, Hülya; Ergene, Emel; Çiftçi, Gülsen Akalın (Natl Inst Science Communication-Niscair, 2013)The aims of this study are the investigation of the effects of fibronectin and type IV collagen extracellular matrix proteins and the role of caspase-3 and -9 on cis-platin induced U2-OS apoptosis were studied. First the ... -
The effects of some phenanthroline ruthenium (II) complexes on a549 cell proliferation
Ruthenium (II) komplekslerinin DNA bağlanması He ilgili olan yüksek antitumor aktiviteleri nedeni He bu bileşikler son yıllarda araştırmacıların yoğun ilgisini çekmektedir. Bu çalismada imidazo[4,5-f][ 1,10]fenantrolin ... -
The effects of some phenanthroline ruthenium (II) complexes on A549 cell proliferation [Bazi{dotless} fenantrolin rutenyum (II) komplekslerinin a549 hücre çogalmasi{dotless} üzerine etkileri]
In recent years, ruthenium (II) complexes have increasingly attracted the interest of researchers because of their high antitumor activities that are usually related to DNA binding. Here, we synthesized two ruthenium (II) ... -
Effects on Caspases Activation By Using a Combination of Cis-Platin With E-Viniferin in Rat Glioma Cells
Mert, Nur İpek Önder; Sen, Mesut; Apaydın, Elif; Seller, Zerrin; Özdemir, Filiz (International Institute of Anticancer Research, 2014)… -
H-ras aktif fibroblast hücre apoptozunun bazı 1,3-bis-(heteroaril substitue) benzen türevleri ile uyarılması
Akalın Çiftçi, Gülsen; Seller, Zerrin (2006)Apoptoz embiryonik gelişim ve doku homeostazın düzenlenmesi esnasında oluşan normal fizyolojik bir olaydır. Günümüzde bazı kemotröpatik ajaların hücre içersinde apoptoz yolaklarını stimüle edebilme yeteneğine sahip olduğu ... -
HepG2 hücrelerinde Vinkristin sülfat/?-viniferin kombinasyonunun vinkristin sülfat ile karşılaştırıldığında artmış etkinliğinin vurgulanması
Amaç: Bu çalışma HepG2 hücre hattında geç apoptoz ve mitokondriyal yolakta ?-viniferin (?-VNF)'in etkisini incelemek için dizayn edildi. Bu amaç için, HepG2 hücre dizisinde anti-kanser ilaç olarak kullanılan vinkristin ... -
Hipoksi koşullarda kanser hücrelerinin glukoz metabolizması ve apoptozunun incelenmesi
Seller, Zerrin; Anadolu Üniversitesi, Sağlık Bilimleri Enstitüsü; Öğünç, Yüksel (Anadolu Üniversitesi -Sağlık Bilimleri Enstitüsü, 2021)Kanser hücrelerinin birçoğu “Warburg etkisi” olarak adlandırılan normoksik koşullar altında bile daha çok hızlandırılmış glikolizle enerji üretmekte ve laktik asit fermantasyonu yapmaktadır. Apoptoz mekanizmasının ... -
Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-RAS oncogene
Sivas, Hülya; Seller, Zerrin; Başer, K. Hüsnü Can (Urban & Fischer Verlag, 2003)Monoterpenes are dietary components found in the essential oils of a wide variety of plants. A number of these monoterpenes have antitumor activity. We have investigated the effects of carvacrol obtained by fractional ... -
Investigation of signal transduction pathways involved in melanoma cell spreading
Seller, Zerrin; Hart, I. R. (2000)Integrins are a major family of heterodimeric adhesion receptors that are responsible for anchoring cells to extracellular matrix and they also can initiate intracellular signal pathways. Here parental and ?4-expressing ... -
Modification of intracellular free calcium in cultured F2408 embryo fibroblasts by 3-sub substituted-2-thiohydantoin derivatives
Seller, Zerrin; Benkli, Kadriye; Akalın, G; Kaplancıklı, Zafer Asım (Wiley, 2004)3-substituted-2-thiohydantoin derivatives were synthesized and their Structures elucidated by IR, H-1-NMR spectroscopy and elemental analysis. The cytotoxicity of the 2-thiohydantoin derivatives to rat embryo fibroblasts ... -
Preperation and in vitro characterization of epsilon-viniferine and vincristine sulfate loaded PLGA-b-PEG nanoparticles
Öğünç Keçeci, Yüksel; Demirel, Müzeyyen; Yakar, Arzu; Seller, Zerrin (Lippincott Williams & Wilkins, 2015)… -
The role of P13-kinase on melanoma cell adhesion and migration
Seller, Zerrin; Hart, R. Ian (2001)Integrins are responsible for anchoring cells to the extracellular matrix and also can initiate intracellular signal pathways. The interaction between integrins and the extracellular matrix results in activation of PKC, ... -
The study on the synthesis and the effects on the intracellular calcium of some 9-substituted-phenanthrene derivatives.
Işıkdağ, İlhan; Meriç, Asiye; Gÿnes, S.; Seller, Zerrin (2004)Some 9-(substituted with heteroaryl)-phenanthrene compounds, polycyclic aromatic hydrocarbons (PAH), were obtained by two different methods. In the first method, 9-phenanthraldehyde was reacted with some dion compounds ...