Yazar "Seller, Zerrin" için listeleme
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Synthesis and anticancer activity of some bisquinoxaline derivatives [Bazi biskinoksalin türevlerinin sentezleri ve antikanser aktiviteleri]
Işıkdağ, İlhan; Özkay, Yusuf; Seller, Zerrin (2011)Resistance improvement against the existing anticancer agents creates a research area for new anticancer agents. Nevertheless, it is rather difficult to develop a new agent which can selectively inhibit the proliferation ... -
Synthesis and antitumor activity of some 6-chloro- and 6,7-dichloro-2,3-disubstituted-quinoxaline derivatives
Bu çalışmada, 6-kloro- ve 6,7-dikloro-2,3-disübstitüe-kinoksalin türevleri sentezlenerek, sitotoksisiteleri ve antitümör etkileri araştırıldı. 6-Kloro- ve 6,7-dikloro-2,3-disübstitüe-kinoksalin bileşikleri, uygun 1,2-dikarbonil ... -
Synthesis and cytotoxic and analgesic activities of some 1, 5-diaryl-3-ethoxycarbonylpyrrole derivatives
Demirayak, Şeref; Arslan, Rana; Karaburun, Ahmet Çağrı; Kayagil, İsmail; Seller, Zerrin; Uçucu, Ümit (2006)Some 1,5-diaryl-3-ethoxycarbonyl-2-methylpyrrole derivatives were obtained by reacting 1-aryl-3-ethoxycarbonylpent-1,4-diones and a suitable aniline derivative or sulfanilamide under Paal-Knorr pyrrole synthesis conditions. ... -
Synthesis and effects on intracellular calcium of some 1,3-bis-(heteroaryl substituted)benzene derivatives
Meriç, Asiye; Seller, Zerrin; Işıkdağ, İlhan (2002)A series of 1,3-bis-(heteroaryl substituted)benzene derivatives was designed as promising molecules which might increase intracellular Ca2+ level in F2408 fibroblast-like cells by affecting the Ca2+ channels on plasma ... -
Synthesis and Evaluation of New Dithiocarbamic Acid 6,11-Dioxo-6,11-dihydro-1H-anthra[1,2-d]-imidazol-2-yl Methyl Esters
Önder, Nur İpek; Seller, Zerrin; Özkay, Yusuf (Wiley-V C H Verlag GMBH, 2015)A novel series of dithiocarbamic acid 6,11-dioxo-6,11-dihydro-1H-anthra[1,2-d]imidazol-2-yl methyl esters were synthesized and their cytotoxic and apoptotic activities were evaluated on HeLa cells. Some of these compounds ... -
Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl]acetamide derivatives and evaluation of their anticancer activity
Özkay, Yusuf; Işıkdağ, İlhan; Seller, Zerrin; Akalın Çiftçi, Gülsen (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In the present study 18 novel imidazole-(benz)azole and imidazole-piperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR, ... -
Synthesis of platinum(II) complexes of 1-aryl-3-(benzimidazole-2-yl)- pyrazole-4-ketoximes and studies on their cytotoxic effects
In this research, synthesis of some complexes in the presence ofPt(II) were studied. The structure of the compounds were elucidated by IR, 1H-NMR, Mass and Elemental Analyses. The cytotoxicity of Pt-complex was evaluated. ... -
Synthesis of some 2,4-di- and 2,3,4-trisubstituted benzimidazo[1,2-a] pyrimidines and evaluation of their cytotoxicities towards F2408 and 5RP7 cells
Meriç, Asiye; Seller, Zerrin; Karayel, Arzu; Özbey, Süheyla (SYSCOM 18 S.R.L., 2006)This article describes the synthesis of 2,4-di- and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidine derivatives which were tested for their cytotoxicities and their spectral characterizations by IR, 1H- and 13C-NMR, ... -
Synthesis of some 2,4-di- and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidines and evaluation of their cytotoxicities towards F2408 and 5RP7 cells
Meriç, Asiye; Seller, Zerrin; Karayel, Arzu; Özbey, Süheyla (Chiminform Data S A, 2006)This article describes the synthesis of 2,4-di- and 2,3,4-trisubstituted benzimidazo[1,2-alpyrimidine derivatives which were tested for their cytotoxicities and their spectral characterizations by IR, H-1- and C-13-NMR, ... -
Synthesis of some 3,4-disubstituted-6,7-dihydro-imidazo[2,1-b][1,3]thiazole and 3,4-disubstituted-7,8-dihydro-6H-imidazo[2,1-b][1,3]thiazine derivatives and evaluation of their cytotoxicities against F2408 and 5RP7 cells
Meriç, Asiye; Seller, Zerrin; Hatipoğlu, İbrahim (Birkhauser Boston Inc, 2008)This article describes the synthesis of 3,4-disubstituted-6,7-dihydro-imidazo[2,1-b][1,3]thiazoles and 3,4-disubstituted-7,8-dihydro-6H-imidazo[2,1-b][1,3]thiazines, having substituted or nonsubstituted phenyl rings at the ... -
Synthesis, characterization of some transition-metal complexes of a new heptadentate N(5)S(2) Schiff-base ligand and the effects of these metal complexes on U2OS cells cytotoxicity and DNA cleavage activity
Uluçam, G.; Beynek, Nesrin; Seller, Zerrin; Akalın Çiftçi, Gülsen; Turan, Gülhan; Benkli, Kadriye (Taylor & Francis LTD, 2008)Metal complexes of a heptadentate N(5)S(2) donor Schiff-base ligand were synthesized by the template reaction between 2,6-bis(2-aminothiophenoxymethyl)pyridine and 2,2 '-bipyridine-6,6'-dicarboxaldehyde in the presence of ... -
Towards Novel Anti-tumor Strategies for Hepatic Cancer: epsilon-Viniferin in Combination with Vincristine Displays Pharmacodynamic Synergy at Lower Doses in HepG2 Cells
Özdemir, Filiz; Akalın Çiftçi, Gülsen; Sen, Mesut; Önder, Nur İpek; İşcan, Arzu; Kutlu, Hatice Mehtap; Seller, Zerrin (Mary Ann Liebert, Inc, 2014)Hepatocellular carcinoma is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. The efficacy of novel combination treatments are increasingly evaluated with use of integrative biology ... -
Ultrastructural Examination of Intracellular Calcium Changes in Ovarian Cancer
Ayrım, Aysun; Dağ, İlknur; Seller, Zerrin (Parlar Scientific Publications (PSP), 2017)In this study, following the fibronectin-coated integrin activation in ovarian cancer cells (SKOV-3), endoplasmic reticulum (ER) stress was generated by intracellular calcium increase and then possible apoptotic effects ... -
Vincristine and epsilon-viniferine-loaded PLGA-b-PEG nanoparticles: pharmaceutical characteristics, cellular uptake and cytotoxicity
Ogunc, Yüksel; Demirel, Müzeyyen; Yakar, Arzu; Seller, Zerrin (Taylor & Francis LTD, 2017)The objective of this study was to prepare the epsilon-viniferine and vincristine-loaded PLGA-b-PEG nanoparticle and to investigate advantages of these formulations on the cytotoxicity of HepG2 cells. Prepared nanoparticle ...