Browsing by Author "Erol, Kevser"
Now showing items 1-14 of 14
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Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium
Tosun, Fatma; Kızılay, Çiğdem Akyüz; Erol, Kevser; Kılıç, Fatma Sultan; Kürkçüoğlu, Mine; Başer, K. Hüsnü Can (Elsevier Sci LTD, 2008)The anticonvulsant activity of furanocoumarins, coumarin mixture and the essential oil obtained from the fruits of Heracleum crenatifolium was examined against maximal electroshock (MES)-induced seizures in mice. Bergapten ... -
Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery
Kırımlıoğlu, Gülsel Yurtdaş; Yazan, Yasemin; Erol, Kevser; Unel, Çiğdem Cengelli (Elsevier Science BV, 2015)Gamma-aminobutyric acid (GABA) is a key neurotransmitter where it usually inhibits impulse transmission. GABA release blockage or postsynaptic reaction were determined to provoke epileptic convulsions. The aim of the present ... -
In vitro/in vivo evaluation of gamma-aminobutyric acid-loaded N,N-dimethylacrylamide-based pegylated polymeric nanoparticles for brain delivery to treat epilepsy
Kırımlıoğlu, Gülsel Yurtdaş; Menceloğlu, Yusuf; Erol, Kevser; Yazan, Yasemin (Taylor & Francis LTD, 2016)Objectives of this study were the delivery of gamma aminobutyric acid (GABA) into the brain by means of developing brain targeted, nanosized, non-toxic and biocompatible polymeric nanoparticles, and investigating their ... -
New beta-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents
Akgün, H; Balkan, A; Erol, Kevser; Batu, Ö. S. (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1998)Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5-dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated ... -
New ß-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents
Akgün, H.; Balkan, A.; Erol, Kevser; Batu, Ö. S. (1998)Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5- dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated ... -
Physicochemical characterization and pharmacokinetic evaluation of rosuvastatin calcium incorporated solid lipid nanoparticles
Al-Heibshy, Fawaz N. S.; Basaran, Ebru; Arslan, Rana; Ozturk, Naile; Erol, Kevser; Demirel, Muzeyyen (Elsevier, 2020)Rosuvastatin calcium (RCa) is a very efficient antihyperlipidemic agent, however, being a BCS class II drug, results in poor oral bioavailability. the present study focused on the enhancement of oral bioavailability of RCa ... -
Some new 7-aryloxyalkyltheophyllines as bronchodilators
Akgün, H; Balkan, A; Günay, S; Erol, Kevser; Boydağ, S (Editions Scientifiques Medicales Elsevier, 1997)… -
Synthesis and analgesic activity of some triazoles and triazolothiadiazines
Turan, Gülhan; Kaplancıklı, Zafer Asım; Erol, Kevser; Kılıç, Fatma Sultan (Elsevier Science Sa, 1999)The synthesis of some triazoles and triazolothiadiazines starting from (5,6,7,8-tetrahydronaphthalen-2-yl)oxyacetic acid is described. The chemical structure of the compounds were elucidated by analytical, IR, H-1 NMR and ... -
Synthesis of some 2-[(benzazole-2-yl)thioacetyl]phenol derivatives and preliminary investigation on their vasodilatory activity
Turan, Gülhan; Demirayak, Şeref; Erol, Kevser; Özdemir, M. (1994)Some 2-[(benzazol-2-yl)thioacetyl]phenol derivatives were synthesized and their structures were elucidated by IR, NMR and microanalyses. The vasodilatory activity of the obtained compounds was investigated. -
Synthesis of some 5-methoxy-3-[(benzazole-2-yl)thioacetylamino]-2,3-dihydrobenzofuran derivatives and study of their antihypertensive activity [SYNTHESE DE CERTAINS DERIVES DE METHOXY-5 [(BENZAZOLE-2-YL)THIOACETYLAMINO]-3 DIHYDRO-2,3 BENZOFURANE ET RECHERCHE D'ACTIVITE ANTIHYPERTENSIVE]
Turan, Gülhan; Demirayak, Şeref; Erol, Kevser; Özdemir, M. (1994)In this study, some 5-methoxy-3-[(benzazole-2-yl) thioacetylamino]2,3-dihydrobenzofuran derivatives were synthesized and their structures were elucidated by IR, NMR and microanalyses. The antihypertensive activities of the ... -
Synthesis of some 5-methoxy-3-[(benzazole-2-yl)thioacétylamino]-2,3 -dihydrobenzofuran derivatives and investigation of antihypertensive activities [Synthèse de quelques dérivés de méthoxy-5 [(benzazole-2-yl)thioacétylamino]-3 dihydro-2,3 benzofuranne et recherche d'activité antihypertensive]
Turan, Gülhan; Demirayak, Şeref; Erol, Kevser; Özdemir, M. (1996)In this study, some 5-methoxy-3-[(benzazole-2-yl)thioacetylamino]-2,3-dihydrobenzofuran derivatives were synthesized and their structures were elucidated by IR, NMR and microanalyses. The antihypertensive activities of the ... -
Synthesis of some chroman derivatives and preliminary investigation on their vasodilatory activity
Turan, Gülhan; Chevallet, P.; Erol, Kevser; Boydağ, B. S. (1997)In this study, some N'-(chroman-4-yliden)-4-aryl-2-thiazolyl derivatives were synthesized. Their structures were elucidated by IR, NMR and microanalyses. The vasodilatory activities of the compounds obtained were examined ... -
Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity
Turan, Gülhan; Chevallet, P; Kılıç, FS; Erol, Kevser (Editions Scientifiques Medicales Elsevier, 2000)Some 1-(4-arylthiazol-2-yl)-3,5-diaryl-2-pyrazoline derivatives were synthesized by reacting 1-thiocarbamoyl-3,5-diaryl-2-pyrazoline derivatives with phenacetylbromide in ethanol. The structural elucidation of the compounds ... -
The synthesis of some triazolylphenothiazine derivatives and their antidepressant and anxiolytic activities
10-[2-(4-Amino-5-mercapto-1,2,4-triazol-3-yl)ethyl]phenothiazine was prepared starting from 3-(10-phenothiaziniyl)propionic acid. This new triazole was employed in the synthesis of some Schiff bases and N-bridged heterocycles. ...