Browsing by Author "Işıkdağ, İlhan"
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Anticancer Activity of Some Bisbenzimidazoles
Işıkdağ, İlhan; Özkay, Yusuf; İncesu, Zerrin; Akalın Çiftçi, Gülsen (Verlag Z Naturforsch, 2011)The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bishenzimidazole derivatives are important compounds known as DNA topoisomerase 1 inhibitors. In the present study, some ... -
Antihelminthic activity and QSARs, of some 2-alkyl-5-chloro-benzimidazole derivatives
Uçucu, Ümit; Işıkdağ, İlhan; Tanol, M. (1992)[No abstract available] -
Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety
Özkay, Yusuf; Tunalı, Yağmur; Karaca, Hülya; Işıkdağ, İlhan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In this study 12 novel benzimidazole compounds bearing hydrazone moiety were synthesized in order to investigate their possible antibacterial and antifungal activity. Structures of the synthesized compounds were elucidated ... -
Antimicrobial Activity of a New Combination System of Benzimidazole and Various Azoles
Özkay, Yusuf; Tunalı, Yağmur; Karaca, Hülya; Işıkdağ, İlhan (Wiley-Blackwell, 2011)In the present study a new series of benzimidazole derivatives bearing various (benz)azolylthio moieties were synthesized so as to investigate their antimicrobial activity. Structures of the target compounds (5a-5i) were ... -
Antimicrobial Activity of a New Series of Benzimidazole Derivatives
Özkay, Yusuf; Tunalı, Yağmur; Karaca, Hülya; Işıkdağ, İlhan (Pharmaceutical Soc Korea, 2011)Due to antimicrobial importance of benzimidazoles and hydrazones, some benzimidazole-hydrazone compounds were synthesized to screen their antimicrobial activity. Structures of the synthesized compounds were elucidated by ... -
Antimicrobial and anticancer effects of some 2-(substitutedsulfanyl)-N-(5-methyl-isoxazol-3-yl)acetamide derivatives
Özkay, Yusuf; Seller, Zerrin; Önder, Nur İpek; Tunalı, Yağmur; Karaca Gencer, Hülya; Işıkdağ, İlhan; Uçucu, Ümit (Springer Birkhauser, 2013)In the present study, some isoxazole-(benz)azole derivatives (3a-3j) were synthesized by considering antimicrobial and anticancer potencies of azole compounds. Chemical structures of obtained compounds (3a-3j) were confirmed ... -
Antimicrobial Effect of Some New 2,5-Disubstituted Benzimidazoles
Özkay, Yusuf; Tunalı, Yağmur; Karaca, H.; Işıkdağ, İlhan (Elsevier Science BV, 2011)… -
Antiproliferative effects of some N-benzylideneanilines
Özkay, Yusuf; Seller, Zerrin; Işıkdağ, İlhan; Yesilkaya, Mehmet (John Wiley & Sons LTD, 2008)A series of Schiff bases including N-benzylideneaniline (NBA) nuclei were prepared. The chemical products obtained were characterized by mass spectometry (APCI), H-1 NMR, and IR spectroscopy in order to seek their cytotoxic ... -
Bazı 9-Sübstitüe Fenantren Türevlerinin Mutajenik Aktivitelerinin Ames / Salmonella / Mikrozom Testi ile Araştırılması
Kutlu, Mehtap; Öztaş, Esin; Aydoğan, Gözde; Işıkdağ, İlhan; Özkay, Yusuf (Anadolu Üniversitesi, 2011)Bu çalışmada, ilaç ön maddesi olarak sentezlenmiş olan üç farklı 9-Sübstitüye fenantren türevi, Ames test yöntemi kullanılarak, Salmonella typhimurium TA 98 ve TA 100 suşları yardımı ile muta-jenik potansiyelleri açısından ... -
Benzimidazol derivatives: Synthesis, antibacterial activity and QSARs of some 2-alkyl-5-chloro-benzimidazoles
Işıkdağ, İlhan; Uçucu, Ümit; Demirayak, Şeref; Çakır, B. (1989)[No abstract available] -
Biological activity of some 4,5-di and 2,4,5-trisubstituted imidazole derivatives: Antihelmintic activity
Uçucu, Ümit; Işıkdağ, İlhan; Çakır, B. (1988)[No abstract available] -
Central nervous system activity of 2-(Naphthalen-1-yl)-4, 5-dimethyl-(1H)-imidazole(NDI)
Özkay, Yusuf; Özkay, Ümide Demir; Can, Özgür Devrim; Öztürk, Yusuf; Işıkdağ, İlhan (Blackwell Publishing, 2006)… -
Cytotoxic effects of some perimidine derivatives on F2408 and 5Rp7 cell lines
Işıkdağ, İlhan; Seller, Zerrin; Gülnaz, D.; Özkay, Yusuf (2008)In this study twenty perimidine derivatives were prepared in order to seek their cytotoxic and antiproliferative effects on normal rat embryo fibroblast (F2408) and carcinogenic rat embryo fibroblast (5RP7) cell lines. ... -
Mutagenicity of Bisbenzimidazole Derivatives
Alanyalı, Susuz,Filiz; Arıcı, Merve; Artagan, Oge; Işıkdağ, İlhan; Özkay, Yusuf (Verlag Z Naturforsch, 2010)The mutagenicities of 2.2'-(di-3-hydroxyphenyl)-1H,1H'-[5,5']-bisbenzimidazole, 2,2'-(di-4-hydroxyphenyl)-1H,1H'-[5,5']-bisbenzimidazole, 2,2'-(di-3-methoxyphenyl)-1H,1H'-[5.5']-bisbenzimidazole, 2,2'-bis-(4-nitrophenyl) ... -
Novel imidazole derivatives as antifungal agents: Synthesis, biological evaluation, ADME prediction and molecular docking studies
Altındağ, Firuze Diyar; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Işıkdağ, İlhan; Özkay, Yusuf; Karaca Gencer, Hülya (Taylor & Francis LTD, 2019)A series of 2-(substituteddithiocarbamoyl)-N-[4-((1H-imidazol-1-yl)methyl)phenyl]acetamide derivatives was designed and synthesized to combat the increasing incidence of drug-resistant fungal infections. All synthesized ... -
Production of ?-terpineol from ?-pinene
?-Terpineol is a monoterpene alcohol used as a fragrance material in perfumery industry and for the production of some volatile compounds. Several techniques have been described in the literature for its synthesis. These ... -
QSAR of inhibitory activities by 2,4,5-trisubstituted imidazole derivatives on tubifex worms
Işıkdağ, İlhan; Uçucu, Ümit; Gündoğdu, N. (1995)[No abstract available] -
QSAR of inhibitory activities by 2-substituted-4,5-difuryl imidazole derivatives on tubifex worms
Işıkdağ, İlhan; Uçucu, Ümit (1995)[No abstract available]