Ara
Toplam kayıt 139, listelenen: 71-80
The synthesis and evaluation of anti-acetylcholinesterase activity of some 4(3H)-quinazolinone derivatives bearing substituted 1,3,4- thiadiazole
(Marmara University, Fac Medicine, 2017)
In the present study, a series of 4(3H)-quinazolinone derivatives (5a-f) were synthesized through the cylization reaction of substituted 1,3,4-thiadiazoles containing an aromatic primary amin and anthranilic acid in the ...
Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
(MDPI, 2019)
Discovery of novel anticandidal agents with clarified mechanisms of action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to existing drugs. In support to this ...
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
(MDPI, 2018)
With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a-3l) were synthesized and characterized. Due to thione-thiol tautomerism in the ...
Synthesis, antimicrobial activity and cytotoxicity of some new carbazole derivatives
(Informa Healthcare, 2012)
In this work, some N-(9-Ethyl-9H-carbazole-3-yl)-2-(phenoxy) acetamide derivatives were synthesised and evaluated for their antimicrobial activity and cytotoxicity. The structural elucidation of the compounds was performed ...
Synthesis, anticandidal activity and cytotoxicity of some tetrazole derivatives
(Taylor & Francis LTD, 2014)
In this study, 14 different 2-[(1-methyl-1H-tetrazole-5-yl)thio]-1-(phenyl) ethanone derivatives (1-14) were synthesized. The structures of the obtained compounds were elucidated using IR, H-1-NMR, C-13-NMR and FAB(+)-MS ...
Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
(MDPI AG, 2017)
In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel ...
Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
(Taylor & Francis LTD, 2017)
In the present study, a new series of 2-[4-(pyrimidin-2-yl) piperazin-1-yl]-2-oxoethyl 4-substituted piperazine- 1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory ...
Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
(Georg Thieme Verlag Kg, 2017)
Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ...
Synthesis of some novel 2-substituted benzothiazole derivatives containing benzylamine moiety as monoamine oxidase inhibitory agents
(Taylor & Francis LTD, 2016)
In the present work, 12 new 2-(5-substituted-benzothiazol-2-ylsulfanyl)-N-(substitutedbenzyl)-N-(4-substitutedphenyl) acetamide derivatives (4a-l) was designed and synthesized. The structures of the synthesized compounds ...
Synthesis and biological evaluation of some new pyrimidine bearing 2,5-disubstituted 1,3,4-oxadiazole derivatives as cytotoxic agents
(Walter De Gruyter GMBH, 2017)
Objective: As a result of adverse effects including drug-resistance, toxicity and low bioavailability, there has been a crucial need for novel anticancer agents. In this present study, some novel 2,5-disubstituted ...