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Toplam kayıt 21, listelenen: 1-10
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
(Academic Press Inc Elsevier Science, 2019)
In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, H-1 NMR, C-13 NMR and mass spectroscopies. The inhibitory potency of ...
Synthesis and evaluation of new pyrazoline-thiazole derivatives as monoamine oxidase inhibitors
(HeteroCorporation, 2019)
A novel series of 1,3,5-trisubstituted-2-pyrazoline derivatives (4a-4k) was synthesized and their chemical structures characterized by 1H NMR, 13C NMR, and mass spectroscopy. These compounds were evaluated as inhibitors ...
Synthesis and biological evaluation of some dibenzofuran-piperazine derivatives
(Taylor & Francis LTD, 2016)
In the present paper, a novel series of dibenzofuran-piperazine derivatives were synthesized via the treatment of N-(2-methoxy-3-dibenzofuranyl)-2-chloroacetamide with substituted piperazine derivatives. The chemical ...
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease
(MDPI, 2018)
Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the ...
Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
(MDPI, 2017)
Azole-based antifungal agents constitute one of the important classes of antifungal drugs. Hence, in the present work, 12 new benzimidazole-thiazole derivatives 3a-3l were synthesized to evaluate their anticandidal activity ...
Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
(MDPI, 2019)
Discovery of novel anticandidal agents with clarified mechanisms of action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to existing drugs. In support to this ...
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
(MDPI, 2018)
With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a-3l) were synthesized and characterized. Due to thione-thiol tautomerism in the ...
Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
(MDPI AG, 2017)
In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel ...
Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
(Taylor & Francis LTD, 2017)
In the present study, a new series of 2-[4-(pyrimidin-2-yl) piperazin-1-yl]-2-oxoethyl 4-substituted piperazine- 1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory ...
Synthesis of some novel 2-substituted benzothiazole derivatives containing benzylamine moiety as monoamine oxidase inhibitory agents
(Taylor & Francis LTD, 2016)
In the present work, 12 new 2-(5-substituted-benzothiazol-2-ylsulfanyl)-N-(substitutedbenzyl)-N-(4-substitutedphenyl) acetamide derivatives (4a-l) was designed and synthesized. The structures of the synthesized compounds ...