Ara
Toplam kayıt 20, listelenen: 11-20
Synthesis and Anticandidal Activity of New Imidazole-Chalcones
(MDPI, 2018)
In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl) prop-2-en-1-one derivatives (3a-3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole ...
Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
(MDPI, 2019)
Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly ...
Synthesis of Novel 4-(Dimethylaminoalkyl) piperazine-1-carbodithioate Derivatives as Cholinesterase Inhibitors
(Bentham Science Publ LTD, 2017)
Background: Carbamate compounds have attracted a great deal of interest in medicinal chemistry due to their inhibition potential against cholinesterase enzymes. Method: Hence, this study was undertaken to synthesize new ...
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)
In the recent works, it was shown that numerous thiazolylhydrazine derivatives display hMAO inhibitory activity in the range of micromolar concentration. Hence, in the present study a new series of new thiazole-hydrazines ...
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[dlimidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, ...
Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
(Taylor & Francis LTD, 2017)
In the present study, a new series of 2-[4-(pyrimidin-2-yl) piperazin-1-yl]-2-oxoethyl 4-substituted piperazine- 1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory ...
Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
(MDPI AG, 2017)
In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors. Structures of the obtained compounds (3a-3j) were characterized by IR, 1H-NMR, 13C-NMR, and ...
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
(MDPI, 2018)
With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a-3l) were synthesized and characterized. Due to thione-thiol tautomerism in the ...
Design, synthesis, monoamine oxidase inhibition and docking studies of new dithiocarbamate derivatives bearing benzylamine moiety
(Academic Press Inc Elsevier Science, 2018)
A new series of thirteen 2-[(4-fluorophenyl)(4-nitrobenzyl) amino]-2-oxoethyl-1-substituted-carbodithio ate derivatives (4a-4m) were synthesized and tested for their human monoamine oxidase A and B (hMAO-A and hMAO-B) ...
Synthesis and evaluation of new pyrazoline-thiazole derivatives as monoamine oxidase inhibitors
(HeteroCorporation, 2019)
A novel series of 1,3,5-trisubstituted-2-pyrazoline derivatives (4a-4k) was synthesized and their chemical structures characterized by 1H NMR, 13C NMR, and mass spectroscopy. These compounds were evaluated as inhibitors ...