Ara
Toplam kayıt 108, listelenen: 1-10
Pirimidin içeren bazı yeni 2,5-disübstitüe 1,3,4-oksadiazol türevlerinin sentezi ve sitotoksik ajan olarak değerlendirilmesi
(2017)
Amaç: Kansere karşı günümüzde kullanılan ilaçların ilaç direnci, toksisite ve düşük biyoyararlanım gibi advers etkilerden dolayı, tedavide yeni antikanser ajanların varlığına ihtiyaç duyulmaktadır. Bu çalışmada pirimidin ...
Novel Naphthyridine-Hydrazone Derivatives and their Antimicrobial Activity
(2014)
Amaç: Bu çalışmada, on yeni Naftiridin-Hidrazon türevinin sentezi ve antimikrobiyal aktivitelerinin değerlendirilmesi amaçlanmıştır. Materyal ve Metod: Sentezlenen bileşiklerin yapıları 1H-NMR ve MS spectral verileri ile ...
Synthesis of Some N-(Benzothiazol-2-YL)-2-(4H-[1,2,4]Triazol -3- Ylsulfanyl)Acetamides and Their Antimicrobial Activity
(Anadolu Üniversitesi, 2011)
The aim of this study is to synthesize novel benzothiazolyl-amide derivatives and investigate their antimicrobial activities. N-(Benzothiazol-2-yl)-2-(4H-[1,2,4]triazol-3-ylsulfanyl) acetamide derivatives (3a-j) were ...
Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents
(Georg Thieme Verlag Kg, 2015)
In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]- ...
Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors
(Bentham Science Publ LTD, 2018)
Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language ability and other cognitive deterioration, ...
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
(Academic Press Inc Elsevier Science, 2019)
In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, H-1 NMR, C-13 NMR and mass spectroscopies. The inhibitory potency of ...
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)
New hydrazone derivatives were synthesized via the nucleophilic addition-elimination reaction of 2-[(1-methyl-1H-tetrazol-5-yl]thio)]acetohydrazide with aromatic aldehydes/ketones. The compounds were tested in vitro against ...
Synthesis of 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and evaluation of their anticancer activity
(Informa Healthcare, 2013)
In the present study, 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives (1-6) were synthesized via the ring closure reaction of 1-(2-thienyl)-3-aryl-2-propen-1-ones with hydrazine hydrate in acetic acid. The chemical ...
Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
(MDPI, 2017)
In the present work, 14 new 1-substituted-2-phenylhydrazone derivatives were synthesized to evaluate their inhibitory activity against hMAO enzymes. The structures of the newly synthesized hydrazones 2a-2n were characterized ...
Synthesis and anticandidal activity of new triazolothiadiazine derivatives
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2011)
New triazolothiadiazine derivatives were synthesized via the ring closure reaction of 4-amino-5-substituted-2,4-dihydro-3H-1,2,4-triazol-3-thiones with phenacyl bromides. The compounds were tested in vitro against various ...