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Toplam kayıt 16, listelenen: 1-10
Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents
(Bentham Science Publ LTD, 2018)
Background: Arylidene indanones have attracted a great deal of interest due to their outstanding therapeutic applications. In particular, considerable research has pointed out the importance of arylidene indanones in the ...
Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
(Bentham Science Publ LTD, 2017)
Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ...
Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives
(Bentham Science Publ LTD, 2017)
Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of ...
Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents
(Bentham Science Publ LTD, 2018)
Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and ...
Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
(Bentham Science Publ LTD, 2015)
Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a ...
Some Thiazole Derivatives Combined with Different Heterocycles: Cytotoxicity Evaluation and Apoptosis Inducing Studies
(Bentham Science Publ LTD, 2018)
Background: Thiazole ring is an outstanding structure found in many biologically active compounds and clinically available drugs. Because of synthesis simplicity of its derivatives and having a wide range of biological ...
Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines
(Bentham Science Publ LTD, 2017)
Background: A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. Objective: In the present work, it ...
Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors
(Bentham Science Publ LTD, 2018)
Background: 1,3,4-Oxadiazoles have been known with a wide variety of pharmacological activities including anticancer activity. Objective: In this study, novel 2,5-disubstituted 1,3,4-oxadiazole derivatives were synthesized ...
The effects of 1,3 bis (heteroaryl substitued) benzene derivatives on apoptosis of N-ras transformed mouse skeletal muscle cell [1,3-Bi·s (heteroari·l sübsti·tüe) benzen türevleri·ni·n N-ras transform fare kasi hücre apoptozu üzeri·ne etki·leri·]
(2005)
Increasing number of the cells, results of excess divicing of the cells, is balanced by apoptosis which causes elimination of old cells and unfunctional cells. Apoptosis is a programmed cell death obtaining this balance. ...
New Quinoline Based Sulfonamide Derivatives: Cytotoxic and Apoptotic Activity Evaluation Against Pancreatic Cancer Cells
(Bentham Science Publ LTD, 2018)
Background: Quinoline is a privileged scaffold especially known with antimalarial and antibacterial drugs before, presently followed anticancer efficiency with a new group of protein kinase inhibitors. Objective: In this ...