Yazar "Can, Özgür Devrim" için WoS İndeksli Yayınlar Koleksiyonu listeleme
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Effect of mianserin on streptozotocin-induced hyperglycemia and metabolic alterations in rats
Can, Özgür Devrim; Üçel, İrfan Umut; Özkay, Ümide Demir; Dikmen, Miriş (Çukurova University, Fac Medicine, 2017)Purpose: The aim of this study was to investigate possible effects of atypical antidepressant mianserin on glycemia levels and metabolic parameters of normoglycemic and diabetic rats Material and Methods: Effects of mianserin ... -
The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet
Can, Özgür Devrim; Ulupınar, Emel; Özkay, Ümide Demir; Yegin, Bengi; Öztürk, Yusuf (Lippincott Williams & Wilkins, 2012)The aim of this study was to examine the effect of simvastatin (SMV), a 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor, in rats fed with a standard or a high-fat diet (HFD) throughout the prenatal and the postnatal ... -
Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms
Aydın, Taliha H.; Can, Özgür Devrim; Özkay, Ümide Demir; Turan, Nazlı (Wiley, 2016)In this study, we investigated the effects of subacute agomelatine (40 and 80 mg/kg) administration on chronic hyperglycemia, metabolic parameters, and pain perception in streptozotocin-induced diabetic rats. Fasting blood ... -
Effects of carvacrol acetate on the isolated rat bladder and vas deferens
Can, Özgür Devrim; Aydın, Süleyman (Wiley-Blackwell, 2004)… -
Effects of hawthorn seed and pulp extracts on the central nervous system
Can, Özgür Devrim; Özkay, Ümide Demir; Öztürk, Nilgün; Öztürk, Yusuf (Informa Healthcare, 2010)Context: Investigating potential central nervous system (CNS) activities of Crataegus monogyna Jacq. (Rosaceae), hawthorn, fruit extracts. Objective: Evaluating CNS effects and analgesic activities of hawthorn fruit extracts ... -
Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity
Can, Özgür Devrim; Özkay, Ümide Demir (Wiley, 2012)The present study was undertaken to investigate the putative activity of a methanol extract of Hypericum montbretti (Guttiferae) on the central nervous system. Rutin (1519 ppm) and quercitrin (784 ppm) were identified as ... -
Effects of Insulin and St. John's Wort Treatments on Anxiety, Locomotory Activity, Depression, and Active Learning Parameters of Streptozotocin-Diabetic Rats
Can, Özgür Devrim; Öztürk, Yusuf; Özkay, Ümide Demir (Georg Thieme Verlag Kg, 2011)The aim of this work was to investigate the effects of St. John's Wort (SJW) extract treatment on behavioral changes arising in streptozotocin (STZ)-diabetic rats. Plus-maze, activity cage, modified forced swimming, and ... -
Effects of long-term agomelatine treatment on the cognitive performance and hippocampal plasticity of adult rats
Özkay, Ümide Demir; Soztutar, Erdem; Can, Özgür Devrim; Ucel, Umut İrfan; Öztürk, Yusuf; Ulupınar, Emel (Lippincott Williams & Wilkins, 2015)Agomelatine is an antidepressant with a distinct pharmacological mechanism of action as an MT1 and MT2 receptor agonist and as a 5-HT2C receptor antagonist. We evaluated the chronic effects of agomelatine administration ... -
Effects of Some 1,3,5-Trisubstitued-2-pyrazoline Derivatives on Depression and Anxiety Parameters of Mice
Can, Özgür Devrim; Özkay, Ümide Demir; Kaplancıklı, Zafer Asım; Öztürk, Yusuf (Pharmaceutical Soc Korea, 2009)The aim of the present study was examining the effects of some 1,3,5-trisubstituted-2-pyrazoline derivatives on depression, anxiety and spontaneous locomotor activity parameters of mice. None of the compounds was effective ... -
Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats
Can, Özgür Devrim; Öztürk, Yusuf; Öztürk, Nilgün; Sagratini, Gianni; Ricciutelli, Massimo; Vittori, Sauro; Maggi, Filippo (Elsevier Science BV, 2011)This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week ... -
An evaluation of the bottom ashes from healthcare waste in a laboratory scale incinerator: Microbiology, mutagenicity and toxicity
Malkoç, Semra; Banar, Müfide; Tüylü, Berrin; Korkmaz, S; Can, Özgür Devrim (Parlar Scientific Publications (PSP), 2006)In this study, experiments of healthcare waste incineration at 500, 600, 700, 800 and 900 degrees C in a lab-scale incinerator were carried out, performing different total bacterial counts for the microorganisms in bottom ... -
Investigating the Antidepressant-like Effects of some Benzimidazolepiperidine Derivatives by In-Vivo Experimental Methods
Turan, Nazlı; Özkay, Ümide Demir; Can, Nafiz Öncü; Can, Özgür Devrim (Bentham Science Publ LTD, 2019)Background: Benzimidazole and piperidine rings are important pharmacophore groups for drug design studies. Objective: In this study, we aimed to investigate the antidepressant-like activity of some 2-(4- substituted-phen ... -
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir; Sağlık, Begüm Nurpelin; Levent, Serkan; Ilgın, Sinem; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[dlimidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, ... -
Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney
Şahin, Erhan; Bektur, Ezgi; Dönmez, Dilek Burukoğlu; Baycu, Cengiz; Can, Özgür Devrim; Şahintürk, Varol (Elsevier GMBH, 2019)Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus. Materials and methods: The rats were randomly ... -
New antidepressant drug candidate: Hypericum montbretti extract
Can, Özgür Devrim; İsmail, İsmail Bilal; Öztürk, Yusuf; Öztürk, Nilgün; Potoğlu-Erkara, Ismuhan; Sagratini, Gianni; Maggi, Filippo (Taylor & Francis LTD, 2011)This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic ... -
New pyrazoline derivatives and their antidepressant activity
Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Altıntop, Mehlika Dilek; Can, Özgür Devrim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental ... -
Opioid system mediated anti-nociceptive effect of agomelatine in mice
Kasap, Merve; Can, Özgür Devrim (Pergamon-Elsevier Science LTD, 2016)Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these ... -
The Other Face of Diabetes Mellitus: Psychiatric and Neurodegenerative Complications: Review
Can, Özgür Devrim; Öztürk, Yusuf (Ortadogu Ad Pres & Publ Co, 2009)Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia, which is caused by failure in insulin secretion and/or action and it triggers various acute and chronic complications in patients. The ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice
Can, Özgür Devrim; Özkay, Ümide Demir; Kıyan, Hülya Tuba; Demirci, Betül (Elsevier GMBH, Urban & Fischer Verlag, 2012)In this study, the effect of Matricaria recutita L essential oil (MEO) on the central nervous system (CNS) of mice was investigated using some behavioral methods. Chemical profiling both by GC and GC-MS analyses of the ...