Yazar "Can, Özgür Devrim" için WoS İndeksli Yayınlar Koleksiyonu listeleme
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Role of St. John'S Wort (Hypericum Perforatum L.) in the Management of Diabetes and Neurological Disorders
Öztürk, Yusuf; Can, Özgür Devrim; Demir-Özkay, Ümide (Apple Acad Press Inc, 2018)St. John's Wort (Hypericum perforatum L.) is a widely utilized antidepressant plant, which has been used as both therapeutic drug and over-the-counter (OTC) product in all around the world. There are many ethnomedical, ... -
Synthesis and analgesic activity of some acetamide derivatives
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Turan, Gülhan; Özdemir, Ahmet; Can, Özgür Devrim (Informa Healthcare, 2012)In the present study, some acetamide derivatives were synthesized and their potential analgesic activities were investigated. N-(benzothiazol-2-yl)-2-[(1-substituted-1H-tetrazol-5-yl) thio] acetamide derivatives were ... -
Synthesis and analgesic effects of 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives
Özkay, Ümide Demir; Özkay, Yusuf; Can, Özgür Devrim (Springer Birkhauser, 2011)This present study was undertaken to synthesize and investigate possible analgesic activities of some 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives that were designed by combining an analgesic ... -
Synthesis and anti-nociceptive, anti-inflammatory activities of new aroyl propionic acid derivatives including N-acylhydrazone motif
Turan, Gülhan; Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Can, Özgür Devrim; Özkay, Ümide Demir (Springer Birkhauser, 2015)In the present study, new 4-[4-[2-(2-(4-substituted benzylidene)hydrazinyl)-2-oxoethoxy]phenyl]-4-oxobutanoic acid derivatives were synthesized, and their anti-nociceptive and anti-inflammatory activities were investigated. ... -
Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives
Özkay, Ümide Demir; Kaya, Ceren; Çevik, Ulviye Acar; Can, Özgür Devrim (MDPI, 2017)Within the scope of our new antidepressant drug development efforts, in this study, we synthesized eight novel benzothiazole derivatives 3a-3h. The chemical structures of the synthesized compounds were elucidated by ... -
Synthesis and antinociceptive activities of some novel benzimidazole-piperidine derivatives
Özkay, Ümide Demir; Can, Özgür Devrim; Turan, Nazlı; Kaya Çavuşoğlu, Betül (Scientific Technical Research Council Turkey-Tubitak, 2017)In this study, a series of benzimidazole-piperidine derivatives were synthesized with the objective of developing potent antinociceptive agents. Some 2-(4-substituted-phenyl) 1 [2 (piperidin-1-yBethyl]-1 H-benzimidazole ... -
Synthesis and antinociceptive activities of some pyrazoline derivatives
Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; Can, Özgür Devrim; Chevallet, Pierre (Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)In the present study, some pyrazoline derivatives were synthesized to investigate their potential antinociceptive activities. 1-[(Benzoxazole/benzimidazole-2-yl)thioacetyl]pyrazoline derivatives were obtained by reacting ... -
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents
Altıntop, Mehlika Dilek; Can, Özgür Devrim; Özkay, Ümide Demir; Kaplancıklı, Zafer Asım (MDPI AG, 2016)In the current work, new 1,3,4-thiadiazole derivatives were synthesized and investigated for their antinociceptive effects on nociceptive pathways of nervous system. The effects of these compounds against mechanical, thermal ... -
Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Can, Özgür Devrim; Özkay, Ümide Demir; Turan, Gülhan (MDPI, 2015)In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a-s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test ... -
Synthesis of new 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluation of their antidepressant-like effects
Özkay, Ümide Demir; Yurttaş, Leyla; Özkay, Yusuf; Ucel, Umut İrfan; Can, Özgür Devrim; Öztürk, Yusuf (Pharmaceutical Soc Korea, 2013)In this study, we synthesized eight novel 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluated their antidepressant-like activities. The chemical structures of the synthesised compounds were elucidated ... -
Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
TokgÖz, Gamze; Özkay, Ümide Demir; Osmaniye, Derya; Yücel, Nazlı Turan; Can, Özgür Devrim; Kaplancıklı, Zafer Asım (MDPI, 2018)Novel benzazole derivative compounds 4a-4h were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds ... -
Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities
Can, Nafiz Öncü; Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir (MDPI, 2018)Novel thiadiazole derivatives were synthesized through the reaction of acetylated 2-aminothiadiazole and piperazine derivatives. The chemical structures of the compounds were clarified by Infrared Spectroscopy (IR), H-1 ... -
Synthesis of Some Thiadiazole Derivatives as New Anticonvulsant Agents
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Can, Özgür Devrim (Elsevier Science BV, 2011)… -
Synthesis of thiadiazole derivatives bearing hydrazone moieties and evaluation of their pharmacological effects on anxiety, depression, and nociception parameters in mice
Can, Özgür Devrim; Altıntop, Mehlika Dilek; Özkay, Ümide Demir; Ucel, Umut İrfan; Doğruer, Burge; Kaplancıklı, Zafer Asım (Pharmaceutical Soc Korea, 2012)Novel thiadiazole derivatives bearing hydrazone moieties were synthesized through the reaction of 2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio)]acetohydrazide with aldehydes/ketones. The chemical structures of the compounds ...