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dc.contributor.authorÖztürk, Yusuf
dc.contributor.authorAydın, Süleyman
dc.contributor.authorAltan, Vecdi Melih
dc.contributor.authorYıldızoğlu-Arı, Nuray
dc.contributor.authorÖzçelikay, At
dc.date.accessioned2019-10-18T18:44:12Z
dc.date.available2019-10-18T18:44:12Z
dc.date.issued1994
dc.identifier.issn0143-4160
dc.identifier.urihttps://dx.doi.org/10.1016/0143-4160(94)90003-5
dc.identifier.urihttps://hdl.handle.net/11421/10557
dc.descriptionWOS: A1994PC45700003en_US
dc.descriptionPubMed ID: 7982267en_US
dc.description.abstractDiabetes mellitus is a metabolic disease associated with certain complications which have also been demonstrated in the experimental models of this disease. Altered responses to several agonists have been reported in various smooth muscles from alloxan or streptozotocin diabetic animals. Since these reports revealed a defect in the contractile process of smooth muscles from experimentally-induced diabetes, short and long term effects of diabetes on calmodulin levels in the smooth muscles of aorta, trachea, vas deferens and duodenum were investigated using streptozotocin diabetic rats. In spite of the fact that most of the reports have demonstrated the defective contractions in long term diabetic rats, short term effect (for 1 week) of diabetes on calmodulin levels in the smooth muscles of aorta, trachea, vas deferens and duodenum was also investigated in the present study using streptozotocin diabetic rats to understand whether the changes in calmodulin dependent contractile process begin at an earlier stage of the disease. Tissue calmodulin levels of the smooth muscles were measured by the radioimmunoassay technique using a [I-125]-labeled kit. Although rats injected with streptozotocin exerted the characteristics of diabetes such as polyuria, polydipsy, polyphagy and elevated blood glucose levels, unchanged calmodulin levels were found in the rats with short term streptozotocin diabetes. In contrast, long term streptozotocin diabetes (for 8 weeks) was found to cause a significant decrease in tissue calmodulin levels of these four smooth muscles. Taking into consideration the findings obtained, there is a high likelihood that the changes in the calmodulin level of smooth muscles may contribute to the defective contractile responses in diabetes as observed in the previous studies and occur as a long term complication of experimental diabetes.en_US
dc.language.isoengen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.isversionof10.1016/0143-4160(94)90003-5en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEffect of Short and Long-Term Streptozotocin Diabetes on Smooth-Muscle Calmodulin Levels in the Raten_US
dc.typearticleen_US
dc.relation.journalCell Calciumen_US
dc.contributor.departmentAnadolu Üniversitesien_US
dc.contributor.authorIDOZTURK, Yusuf/0000-0002-9488-0891; Ari, Nuray/0000-0002-9259-7427en_US
dc.identifier.volume16en_US
dc.identifier.issue2en_US
dc.identifier.startpage81en_US
dc.identifier.endpage86en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorÖztürk, Yusuf
dc.contributor.institutionauthorAydın, Süleyman


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