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Design, synthesis and biological evaluation of new bis(thiosemicarbazone) derivatives as potential targeted anticancer agents for non-small cell lung cancer
(2020)
Thiosemicarbazonesrepresent an important class of ligandsfortargeted therapyof many types of cancer including non-small celllung cancer. In order to identify potential antitumoragentsfor targeted therapy oflung cancer, new ...
Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors
(Academic Press Inc Elsevier Science, 2019)
The synthesis, characterization and biological evaluation of a series of novel N-substituted phthalazine sulfonamide (5a-1) are disclosed. Phthalazines which are nitrogen-containing heterocyclic compounds are biologically ...
Synthesis and bioactivity of several new hetaryl sulfonamides
(Taylor & Francis LTD, 2017)
1-(4-Methylsulfonyl)-2-thione-4-aryl-5-Z-6-methyl and oxyalkyl-imidazoles were synthesized from different tetrahydropyrimidinethiones and aryl sulfonyl chloride. These compunds were tested for metal chelating effects and ...
Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies
(Taylor & Francis LTD, 2019)
Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an ...
Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study
(Taylor & Francis LTD, 2017)
Aldose reductase (AR) inhibitors have vital importance in the treatment and prevention of diabetic complications. In this study, rat kidney AR was purified 19.34-fold with a yield of 3.49% and a specific activity of 0.88 ...
Inhibition effects of quinones on aldose reductase: Antidiabetic properties
(Elsevier, 2019)
Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a ...
Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity
(Springer, 2019)
Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic complications. Here, AR was purified from sheep kidney ...
Antiepileptic drugs: Impacts on human serum paraoxonase-1
(Wiley, 2017)
Serum paraoxonase (PON1) is a key enzyme related to high-density lipoprotein (HDL)-cholesterol particle. It can prevent the oxidation of low-density lipoprotein (LDL) and HDL. The present article focuses on the in vitro ...
Inhibition effects of pesticides on glutathione-S-transferase enzyme activity of Van Lake fish liver
(Wiley, 2018)
Glutathione-S-transferases (GSTs) have a function in xenobiotic metabolism. They are a significant multifunctional family with a wide variety of catalytic activities. In the current study, we determined in vitro inhibition ...
Evaluation of chalcones as inhibitors of glutathione S-transferase
(Wiley, 2018)
Glutathione S-transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play an important role in cellular signaling. In the present study, potential inhibition effects of chalcones were ...