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Toplam kayıt 49, listelenen: 21-30
The Effect of Agomelatine Treatment on Diabetes-Induced Cognitive Impairments in Rats: Concomitant Alterations in the Hippocampal Neuron Numbers
(MDPI, 2018)
Researches that are related to the central nervous system complications of diabetes have indicated higher incidence of cognitive disorders in patients. Since the variety of nootropic drugs used in clinics is limited and ...
Synthesis and antinociceptive activities of some novel benzimidazole-piperidine derivatives
(Scientific Technical Research Council Turkey-Tubitak, 2017)
In this study, a series of benzimidazole-piperidine derivatives were synthesized with the objective of developing potent antinociceptive agents. Some 2-(4-substituted-phenyl) 1 [2 (piperidin-1-yBethyl]-1 H-benzimidazole ...
Effects of long-term agomelatine treatment on the cognitive performance and hippocampal plasticity of adult rats
(Lippincott Williams & Wilkins, 2015)
Agomelatine is an antidepressant with a distinct pharmacological mechanism of action as an MT1 and MT2 receptor agonist and as a 5-HT2C receptor antagonist. We evaluated the chronic effects of agomelatine administration ...
Central Nervous System Activities of Hypericum origanifolium Extract via GABAergic and Opioidergic Mechanisms
(Wiley, 2013)
Pharmacological effects of hydroalcoholic extract prepared from Hypericum origanifolium Willd. (Guttiferae) on behavioral parameters and pain perceptions of mice were investigated in this study. Depression, anxiety, ...
Mianserin'in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
(2017)
Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin'in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin'in ...
Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of monoaminergic mechanisms
(Elsevier Science BV, 2013)
The present study was designed to investigate the putative effect of vitexin, a flavone C-glucoside present in some drugs, medicinal plants and nutraceuticals, on the central nervous system. Vitexin (10-30 mg/kg) did not ...
Effects of Insulin and St. John's Wort Treatments on Anxiety, Locomotory Activity, Depression, and Active Learning Parameters of Streptozotocin-Diabetic Rats
(Georg Thieme Verlag Kg, 2011)
The aim of this work was to investigate the effects of St. John's Wort (SJW) extract treatment on behavioral changes arising in streptozotocin (STZ)-diabetic rats. Plus-maze, activity cage, modified forced swimming, and ...
Anti-nociceptive effect of vitexin mediated by the opioid system in mice
(Pergamon-Elsevier Science LTD, 2013)
In the present study, we determined the potential anti-nociceptive activity of vitexin, a C-glycosylated flavone, by conducting some acute nociceptive tests in mice. Centrally mediated anti-nociceptive effect was evaluated ...
The Other Face of Diabetes Mellitus: Psychiatric and Neurodegenerative Complications: Review
(Ortadogu Ad Pres & Publ Co, 2009)
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia, which is caused by failure in insulin secretion and/or action and it triggers various acute and chronic complications in patients. The ...
Effect of mianserin on streptozotocin-induced hyperglycemia and metabolic alterations in rats
(Çukurova University, Fac Medicine, 2017)
Purpose: The aim of this study was to investigate possible effects of atypical antidepressant mianserin on glycemia levels and metabolic parameters of normoglycemic and diabetic rats Material and Methods: Effects of mianserin ...