Ara
Toplam kayıt 70, listelenen: 51-60
Synthesis and analgesic effects of 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives
(Springer Birkhauser, 2011)
This present study was undertaken to synthesize and investigate possible analgesic activities of some 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives that were designed by combining an analgesic ...
Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity
(Wiley, 2012)
The present study was undertaken to investigate the putative activity of a methanol extract of Hypericum montbretti (Guttiferae) on the central nervous system. Rutin (1519 ppm) and quercitrin (784 ppm) were identified as ...
Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats
(Elsevier Science BV, 2011)
This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week ...
Opioid system mediated anti-nociceptive effect of agomelatine in mice
(Pergamon-Elsevier Science LTD, 2016)
Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these ...
A Computer Experiment Model to Investigate the Effects of Drug Dosage in Animals, for Use in Pharmacological Education and Research
(Frame, 2011)
The ACD-IDEA database, which was originally developed by the authors in 2004, is an ongoing compilation of existing data on the in vivo doses of compounds at which various responses in certain animal species have been ...
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[dlimidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, ...
Antinociceptive, antiinflammatory, and antioxidant activities of the ethanol extract of Crataegus orientalis leaves
(Tubitak Scientific & Technical Research Council Turkey, 2012)
Aim: To determine the in vitro antioxidant activity and to investigate the possible antinociceptive and antiinflammatory effects of the ethanol extract of Crataegus orientalis leaves. The medicinal use of extracts prepared ...
Inhibition of C6 Glioma Cell Proliferation by Au(III) and Pt(II) Complexes of 1,10-Phenanthroline-5,6-dione
(Asian Journal Of Chemistry, 2011)
In this study, we studied the antiproliferative effecs of Au(III) and Pt(II) metal complexes of 1,10-phenanthroline-5,6-dione and cisplatin on rat glioma C6 cells. The antiproliferative effects were evaluated by MTT ...
Is there any role of G-protein estrogen receptor gene (GPR30) polymorphism in development of schizophrenia?
(Cumhuriyet University Tip Fak Psikiyatri Anabilim Dali, 2019)
Objectives: Schizophrenia is a complex neuropsychiatric disorder that affects approximately 1% of the population. Estrogens may play an important role in the etiology and treatment of this disorder. They mediate effect by ...
Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion
(Taylor & Francis LTD, 2019)
Objectives: Neuropathic pain reduces the life qualities of patients with Diabetes mellitus. Clinical guidelines recommend relief in diabetic neuropathic pain through the use of some antidepressants, anticonvulsants, opioids ...