Ara
Toplam kayıt 181, listelenen: 41-50
New ß-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents
(1998)
Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5- dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated ...
In the present work, Microsteam distillation - Solid phase microextraction (MSD-SPME) and hydrodistillation (HD) techniques were applied to obtain volatiles from Achillea sivasica, an endemic species from Turkey. GC-FID and GC/MS analysis revealed that 1,8-cineole (22.1%) and ?-pinene (9.3%) were the main constituents of the hydrodistilled flower volatiles. (Z)-?-Farnesene (23.9%), decanoic acid (10.1%), ??eudesmol (8.0%), tricosane (7.3%) and hexadecanoic acid (7.2%) were the main volatiles obtained from flowers by MSDSPME. The leaf volatiles obtained by HD contained camphor (9.0%), ?-pinene (6.9%), 1,8-cineole (6.7%), ?-pinene (6.7%) and??-bisabolol (6.6%) as the main constituents while the leaf volatiles obtained by MSD-SPME technique were rich in (E)-geranyl acetone (10.5%), (E)-?-ionone (10.3%), camphor (10.2%), 1,8-cineole (9.6%), longiverbenone (7.9%), ?-eudesmol (7.5%), isopropyl myristate (6.7%) and epi-?-bisabolol (6.4%). The root volatiles were rich in longiverbeno
(2018)
In the present work, Microsteam distillation - Solid phase microextraction (MSD-SPME) and hydrodistillation (HD) techniques were applied to obtain volatiles from Achillea sivasica, an endemic species from Turkey. GC-FID ...
Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae)
(Elsevier Sci LTD, 2016)
In the search for neuroactive compounds that mimic the nerve growth factor (NGF) activity for the protection against neurodegenerative diseases, the potential medicinal values of foods and plants attracts intense interest. ...
Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: A study on mechanism of action
(Elsevier Science BV, 2015)
This study used various experimental pain methods to investigate the effects of subacute mianserin administration on diabetes-induced neuropathic pain in rats. The effect of mianserin on hyperalgesia occurring in connection ...
The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet
(Lippincott Williams & Wilkins, 2012)
The aim of this study was to examine the effect of simvastatin (SMV), a 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor, in rats fed with a standard or a high-fat diet (HFD) throughout the prenatal and the postnatal ...
Antioxidant, Antiproliferative and Apoptotic Effects of Secondary Metabolites of Halotolerant Aspergillus terreus on Colon Adenocarcinoma Caco-2 Cells
(Asian Network Scientific Information-Ansinet, 2017)
Objective: This study aimed to investigate the antioxidant and anticancer effects of the secondary metabolites of halotolerant Aspergillus terreus-2 (hAt-2) on colon adenocarcinoma (Caco-2) cells. The hAt-2 was isolated ...
Comparison of the Effects of Curcumin and RG108 on NGF-Induced PC-12 Adh Cell Differentiation and Neurite Outgrowth
(Mary Ann Liebert, Inc, 2017)
DNA methyltransferases (DNMTs) are promising epigenetic targets for the development of novel drugs, especially for neurodegenerative disorders. In recent years, there has been increased interest in small molecules that can ...
Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney
(Elsevier GMBH, 2019)
Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus. Materials and methods: The rats were randomly ...
Synthesis of new 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluation of their antidepressant-like effects
(Pharmaceutical Soc Korea, 2013)
In this study, we synthesized eight novel 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluated their antidepressant-like activities. The chemical structures of the synthesised compounds were elucidated ...