Ara
Toplam kayıt 49, listelenen: 1-10
Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits
(Polish Acad Sciences Inst Pharmacology, 2012)
Background: In this study, benzothiazolc-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's ...
Opioid system mediated anti-nociceptive effect of agomelatine in mice
(Pergamon-Elsevier Science LTD, 2016)
Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these ...
Synthesis and antinociceptive activities of some novel benzimidazole-piperidine derivatives
(Scientific Technical Research Council Turkey-Tubitak, 2017)
In this study, a series of benzimidazole-piperidine derivatives were synthesized with the objective of developing potent antinociceptive agents. Some 2-(4-substituted-phenyl) 1 [2 (piperidin-1-yBethyl]-1 H-benzimidazole ...
Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
(MDPI, 2018)
Novel benzazole derivative compounds 4a-4h were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds ...
Investigating the Antidepressant-like Effects of some Benzimidazolepiperidine Derivatives by In-Vivo Experimental Methods
(Bentham Science Publ LTD, 2019)
Background: Benzimidazole and piperidine rings are important pharmacophore groups for drug design studies. Objective: In this study, we aimed to investigate the antidepressant-like activity of some 2-(4- substituted-phen ...
Role of St. John'S Wort (Hypericum Perforatum L.) in the Management of Diabetes and Neurological Disorders
(Apple Acad Press Inc, 2018)
St. John's Wort (Hypericum perforatum L.) is a widely utilized antidepressant plant, which has been used as both therapeutic drug and over-the-counter (OTC) product in all around the world. There are many ethnomedical, ...
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1H-benzimidazole 5-carboxylic acid: evidence for the importance of the 2-(o-substituted phenyl) group
(Govi-Verlag GMBH, 2003)
Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ...
Analgesic and sedative activity of 2-(2-Hydroxynaphtholen-1-yl)-5,6-dichloro-(1H)-benzimidazole(HNDCB)
(Blackwell Publishing, 2006)
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Central nervous system activity of 2-(Naphthalen-1-yl)-4, 5-dimethyl-(1H)-imidazole(NDI)
(Blackwell Publishing, 2006)
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Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives
(MDPI, 2017)
Within the scope of our new antidepressant drug development efforts, in this study, we synthesized eight novel benzothiazole derivatives 3a-3h. The chemical structures of the synthesized compounds were elucidated by ...