Kurum Yazarı "Can, Özgür Devrim" Makale Koleksiyonu İçin Listeleme
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Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity
Can, Özgür Devrim; Özkay, Ümide Demir (Wiley, 2012)The present study was undertaken to investigate the putative activity of a methanol extract of Hypericum montbretti (Guttiferae) on the central nervous system. Rutin (1519 ppm) and quercitrin (784 ppm) were identified as ... -
Effects of Insulin and St. John's Wort Treatments on Anxiety, Locomotory Activity, Depression, and Active Learning Parameters of Streptozotocin-Diabetic Rats
Can, Özgür Devrim; Öztürk, Yusuf; Özkay, Ümide Demir (Georg Thieme Verlag Kg, 2011)The aim of this work was to investigate the effects of St. John's Wort (SJW) extract treatment on behavioral changes arising in streptozotocin (STZ)-diabetic rats. Plus-maze, activity cage, modified forced swimming, and ... -
Effects of long-term agomelatine treatment on the cognitive performance and hippocampal plasticity of adult rats
Özkay, Ümide Demir; Soztutar, Erdem; Can, Özgür Devrim; Ucel, Umut İrfan; Öztürk, Yusuf; Ulupınar, Emel (Lippincott Williams & Wilkins, 2015)Agomelatine is an antidepressant with a distinct pharmacological mechanism of action as an MT1 and MT2 receptor agonist and as a 5-HT2C receptor antagonist. We evaluated the chronic effects of agomelatine administration ... -
Effects of Some 1,3,5-Trisubstitued-2-pyrazoline Derivatives on Depression and Anxiety Parameters of Mice
Can, Özgür Devrim; Özkay, Ümide Demir; Kaplancıklı, Zafer Asım; Öztürk, Yusuf (Pharmaceutical Soc Korea, 2009)The aim of the present study was examining the effects of some 1,3,5-trisubstituted-2-pyrazoline derivatives on depression, anxiety and spontaneous locomotor activity parameters of mice. None of the compounds was effective ... -
Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats
Can, Özgür Devrim; Öztürk, Yusuf; Öztürk, Nilgün; Sagratini, Gianni; Ricciutelli, Massimo; Vittori, Sauro; Maggi, Filippo (Elsevier Science BV, 2011)This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week ... -
Investigating the Antidepressant-like Effects of some Benzimidazolepiperidine Derivatives by In-Vivo Experimental Methods
Turan, Nazlı; Özkay, Ümide Demir; Can, Nafiz Öncü; Can, Özgür Devrim (Bentham Science Publ LTD, 2019)Background: Benzimidazole and piperidine rings are important pharmacophore groups for drug design studies. Objective: In this study, we aimed to investigate the antidepressant-like activity of some 2-(4- substituted-phen ... -
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir; Sağlık, Begüm Nurpelin; Levent, Serkan; Ilgın, Sinem; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[dlimidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, ... -
Mianserin'in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin'in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin'in ... -
Mianserin’in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin’in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin’in ... -
Mirtazapin Diyabet Oluşturulan Sıçanların Beyinciklerindeki Hasarı Kısmen Düzeltmektedir
Diabetes mellitus (DM) sistemik bir hastalık olup çeşitli organlarda hasara neden olmaktadır. Bu organlar arasında beyincik de yer almaktadır. Mirtazapin ise majör depresyon tedavisinde kullanılan bir antidepresan madde ... -
Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney
Şahin, Erhan; Bektur, Ezgi; Dönmez, Dilek Burukoğlu; Baycu, Cengiz; Can, Özgür Devrim; Şahintürk, Varol (Elsevier GMBH, 2019)Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus. Materials and methods: The rats were randomly ... -
New antidepressant drug candidate: Hypericum montbretti extract
Can, Özgür Devrim; İsmail, İsmail Bilal; Öztürk, Yusuf; Öztürk, Nilgün; Potoğlu-Erkara, Ismuhan; Sagratini, Gianni; Maggi, Filippo (Taylor & Francis LTD, 2011)This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic ... -
Opioid system mediated anti-nociceptive effect of agomelatine in mice
Kasap, Merve; Can, Özgür Devrim (Pergamon-Elsevier Science LTD, 2016)Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these ... -
Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice
Can, Özgür Devrim; Özkay, Ümide Demir; Kıyan, Hülya Tuba; Demirci, Betül (Elsevier GMBH, Urban & Fischer Verlag, 2012)In this study, the effect of Matricaria recutita L essential oil (MEO) on the central nervous system (CNS) of mice was investigated using some behavioral methods. Chemical profiling both by GC and GC-MS analyses of the ... -
Synthesis and analgesic effects of 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives
Özkay, Ümide Demir; Özkay, Yusuf; Can, Özgür Devrim (Springer Birkhauser, 2011)This present study was undertaken to synthesize and investigate possible analgesic activities of some 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives that were designed by combining an analgesic ... -
Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives
Özkay, Ümide Demir; Kaya, Ceren; Çevik, Ulviye Acar; Can, Özgür Devrim (MDPI, 2017)Within the scope of our new antidepressant drug development efforts, in this study, we synthesized eight novel benzothiazole derivatives 3a-3h. The chemical structures of the synthesized compounds were elucidated by ... -
Synthesis and antinociceptive activities of some novel benzimidazole-piperidine derivatives
Özkay, Ümide Demir; Can, Özgür Devrim; Turan, Nazlı; Kaya Çavuşoğlu, Betül (Scientific Technical Research Council Turkey-Tubitak, 2017)In this study, a series of benzimidazole-piperidine derivatives were synthesized with the objective of developing potent antinociceptive agents. Some 2-(4-substituted-phenyl) 1 [2 (piperidin-1-yBethyl]-1 H-benzimidazole ... -
Synthesis of new 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluation of their antidepressant-like effects
Özkay, Ümide Demir; Yurttaş, Leyla; Özkay, Yusuf; Ucel, Umut İrfan; Can, Özgür Devrim; Öztürk, Yusuf (Pharmaceutical Soc Korea, 2013)In this study, we synthesized eight novel 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluated their antidepressant-like activities. The chemical structures of the synthesised compounds were elucidated ... -
Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
TokgÖz, Gamze; Özkay, Ümide Demir; Osmaniye, Derya; Yücel, Nazlı Turan; Can, Özgür Devrim; Kaplancıklı, Zafer Asım (MDPI, 2018)Novel benzazole derivative compounds 4a-4h were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds ... -
Synthesis of thiadiazole derivatives bearing hydrazone moieties and evaluation of their pharmacological effects on anxiety, depression, and nociception parameters in mice
Can, Özgür Devrim; Altıntop, Mehlika Dilek; Özkay, Ümide Demir; Ucel, Umut İrfan; Doğruer, Burge; Kaplancıklı, Zafer Asım (Pharmaceutical Soc Korea, 2012)Novel thiadiazole derivatives bearing hydrazone moieties were synthesized through the reaction of 2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio)]acetohydrazide with aldehydes/ketones. The chemical structures of the compounds ...