Başlık için Makale Koleksiyonu listeleme
Toplam kayıt 132, listelenen: 86-105
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Investigating the Antidepressant-like Effects of some Benzimidazolepiperidine Derivatives by In-Vivo Experimental Methods
(Bentham Science Publ LTD, 2019)Background: Benzimidazole and piperidine rings are important pharmacophore groups for drug design studies. Objective: In this study, we aimed to investigate the antidepressant-like activity of some 2-(4- substituted-phen ... -
Investigation of association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism frequency and plasma PAI-1 enzyme activity in patients with acute stroke
(Mary Ann Liebert, Inc, 2008)Aim: This study was carried out to determine if there is any association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism and plasma PAI-1 enzyme activity in acute stroke patients. Methods: ... -
Investigation of signal transduction pathways involved in melanoma cell spreading
(2000)Integrins are a major family of heterodimeric adhesion receptors that are responsible for anchoring cells to extracellular matrix and they also can initiate intracellular signal pathways. Here parental and ?4-expressing ... -
Investigation of the Apoptotic Effect of Curcumin in Human Leukemia HL-60 Cells by Using Flow Cytometry
(Mary Ann Liebert, Inc, 2010)Curcumin (diferuloylmethane), the major yellow pigment isolated from the turmeric (Curcuma longa), has received much attention due to several biological properties. Curcumin exhibits a variety of pharmacological effects ... -
The Involvement of NO-cGMP-ATP Sensitive K+ Channels Pathway in Protocatechuic Acid Peripheral Analgesia
(Assoc Pharmaceutical Teachers India, 2017)Protocatechuic acid (PCA) is a widely distributed natural bioactive phenolic acid. The various pharmacological activities such as antioxidant, antidiabetic and anti-inflammatory activities have been identified. However, ... -
Is there any role of G-protein estrogen receptor gene (GPR30) polymorphism in development of schizophrenia?
(Cumhuriyet University Tip Fak Psikiyatri Anabilim Dali, 2019)Objectives: Schizophrenia is a complex neuropsychiatric disorder that affects approximately 1% of the population. Estrogens may play an important role in the etiology and treatment of this disorder. They mediate effect by ... -
Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae)
(Elsevier Sci LTD, 2016)In the search for neuroactive compounds that mimic the nerve growth factor (NGF) activity for the protection against neurodegenerative diseases, the potential medicinal values of foods and plants attracts intense interest. ... -
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[dlimidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, ... -
MgSO 4 and lazaroid (U-83836E) partially protects glioma cells against glutamate toxidty in vitro
(2004)In this study, the possible effects of MgSO 4 and lazaroid (U-83836E) on glutamate toxicity on glial cells were investigated. C6 and human glioblastoma multiforme cells derived from two patients were grown in an incubator. ... -
Mianserin'in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
(2017)Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin'in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin'in ... -
Mianserin’in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
(2017)Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin’in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin’in ... -
Mirtazapin Diyabet Oluşturulan Sıçanların Beyinciklerindeki Hasarı Kısmen Düzeltmektedir
(2018)Diabetes mellitus (DM) sistemik bir hastalık olup çeşitli organlarda hasara neden olmaktadır. Bu organlar arasında beyincik de yer almaktadır. Mirtazapin ise majör depresyon tedavisinde kullanılan bir antidepresan madde ... -
Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney
(Elsevier GMBH, 2019)Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus. Materials and methods: The rats were randomly ... -
mTOR Inhibitors in the Treatment of Cancer
(Marmara University, Fac Pharmacy, 2015)The mammalian target of rapamycin (mTOR) is a highly conserved in evolution serine/threonine kinase belonging to the phosphatidylinositol kinase related protein kinases family. mTOR plays a central role in regulation of a ... -
Nepetalactone: A new opioid analgesic from Nepeta caesarea Boiss.
(Royal Pharmaceutical Soc Great Britain, 1998)The essential oils of Nepeta species including Nepeta phyllochlamys P. H. Davis, N. nuda L. ssp. nude, and N. caesarea Boiss. have been screened by use of the tail-flick and tail immersion (52.5 degrees C) methods. Of the ... -
Neuritogenic Activity of Epigallocatechin Gallate and Curcumin Combination on Rat Adrenal Pheochromocytoma Cells
(Parlar Scientific Publications (PSP), 2017)Plant phytochemicals are important neuroprotective agents which mainly act as antioxidants by scavenging stress -induced free radicals in the brain. Phytochemicals from medicinal plants including epigallocatechin gallate ... -
New antidepressant drug candidate: Hypericum montbretti extract
(Taylor & Francis LTD, 2011)This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic ... -
New beta-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents
(Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1998)Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5-dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated ... -
New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Hydrazones and the piperidine ring containing compounds were considered as beneficial substrates in drug design. Therefore, this study was aimed at the synthesis of new benzoyl hydrazones derived from ethyl 4-oxopiperidi ...