Yayın tarihi için Makale Koleksiyonu listeleme
Toplam kayıt 132, listelenen: 21-40
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Testing wound-healing activity in T15 fibroblast cultures: A morphometric analysis
(Frame, 2000)The purpose was to evaluate the use of mouse T15 fibroblast cell cultures for the investigation of wound-healing activity. In order to investigate their mechanisms of action, the effects of drugs with wound-healing activities ... -
Investigation of signal transduction pathways involved in melanoma cell spreading
(2000)Integrins are a major family of heterodimeric adhesion receptors that are responsible for anchoring cells to extracellular matrix and they also can initiate intracellular signal pathways. Here parental and ?4-expressing ... -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid: Evidence for the importance of the 2-(o-substituted phenyl) group
(2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1H-benzimidazole 5-carboxylic acid: evidence for the importance of the 2-(o-substituted phenyl) group
(Govi-Verlag GMBH, 2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
MgSO 4 and lazaroid (U-83836E) partially protects glioma cells against glutamate toxidty in vitro
(2004)In this study, the possible effects of MgSO 4 and lazaroid (U-83836E) on glutamate toxicity on glial cells were investigated. C6 and human glioblastoma multiforme cells derived from two patients were grown in an incubator. ... -
Composition of the essential oil of Cachrys alpina bieb.
(Allured Publ Corp, 2004)A hydrodistilled essential oil from fruits of Cachrysalpina,was analyzed by GUMS. Twenty-nine compounds representing 98% of the oil were identified with alpha-humulene (33.1%), p-cymene (9.3%). alpha-phellandrene (9.1%) ... -
Effect of an aqueous distillate of Origanum onites L. on isolated rat fundus, duodenum and ileum: Evidence for the role of oxygenated monoterpenes
(Govi-Verlag Pharmazeutischer Verlag GMBH, 2005)The aqueous distillate of Origanum onites L. (Labiatae) was reported to have various ethnomedical uses including effects on the gastrointestinal tract. The effects of three different doses (0.1, 0.2 and 0.4 mL) of the ... -
Chronic heavy ethanol consumption is associated with decreased platelet aggregation in rats
(Tohoku University Medical Press, 2005)Although moderate alcohol consumption seems to be protective against atherosclerosis, coronary artery disease rate increases with its higher doses. Platelet aggregation is an important process which contributes to the ... -
Pharmacological and toxicological effects of gas plant (Dictamnus Albus L.)
(2005)Bu çalışmanın amacı Akgiritotu'nun farmakolojik ve toksikolojik etkilerini araştırmaktır. Yaprak ve meyvalarmdan hazırlanan sulu ekstreler kobay derisi üzerinde 2,4-dinitrobenzen ile karşılaştırmalı olarak test edilmiştir. ... -
Extract of hypericum perforatum blocks nicotine-induced locomotor activitiy in mice
(2006)Sunulan çalışmada, farelerde nikotin ile indüklenen lokomotor aktivite üzerine Hiperikum perforatum ekstresinin etkileri incelenmiştir. Çalışmada denek olarak erişkin erkek Swiss-Webster türü fareler kullanıldı. Nikotin ... -
Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats
(2006)The effects of Hypericum perforatum (St John's wort) on ethanol withdrawal syndrome have been investigated in ethanol-dependent rats. Adult male Wistar rats were subjects. Ethanol (7.2% v/v) was given to rats by a liquid ... -
Effects of streptozotocin-induced diabetes and insulin on calcium responsiveness of the rat vas deferens
(Pergamon-Elsevier Science LTD, 2006)In the present study, effects of streptozotocin-induced diabetes and insulin treatment on the reactivity of rat vas deferens to KCl and calmidazolium, a calmodulin antagonist, were evaluated and calmodulin levels in vas ... -
Extract of Hypericum perforatum blocks nicotine-induced locomotor activity in mice
(2006)In the present study, the effects of Hypericum perforatum on nicotine-induced locomotor activity have been investigated in mice. Adult male Swiss-Webster mice were subjects. Nicotine (0.5, 1 and 2 mg/kg) and saline were ... -
Hypotensive effects of carvacrol on the blood pressure of normotensive rats
(Georg Thieme Verlag Kg, 2007)Carvacrol is the major compound of essential oils of many plants, ethnomedically used for centuries but there were no detailed investigations on its action on the cardiovascular system. The aim of our study was to investigate ... -
Extract of Hypericum perforatum blocks caffeine-induced locomotor activity in mice: A possible role of nitric oxide
(John Wiley & Sons LTD, 2007)The present study investigated the effects of HPE on caffeine-induced locomotor activity in mice. Caffeine (416 mg/kg) or saline were given to adult male Swiss-Webster mice, and the locomotor activity was immediately ... -
Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts
(Elsevier Ireland LTD, 2007)Wound-healing effect of St. John's Wort (Hypericum perforatum L.) extract was evaluated by comparing with dexpanthenol and titrated extract of Centella asiatica TECA) on cultured chicken embryonic fibroblasts. Chicken ... -
Cytotoxic and inhibitory effects of pomegranate peel extract on proliferation of MCF-7 cells [Nar meyve kabugu ekstresi·ni·n mcf-7 hücre proli·ferasyonu üzeri·ne si·totoksi·k ve i·nhi·bi·tör etki·leri·]
(2008)The Pomegranate (Punica granatum L.) is a wonderful fruit which contains a wide variety of precious phytochemical compounds applicable in the fields of therapeutics and health care. Previous studies have demonstrated the ... -
Investigation of association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism frequency and plasma PAI-1 enzyme activity in patients with acute stroke
(Mary Ann Liebert, Inc, 2008)Aim: This study was carried out to determine if there is any association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism and plasma PAI-1 enzyme activity in acute stroke patients. Methods: ... -
Effects of Some 1,3,5-Trisubstitued-2-pyrazoline Derivatives on Depression and Anxiety Parameters of Mice
(Pharmaceutical Soc Korea, 2009)The aim of the present study was examining the effects of some 1,3,5-trisubstituted-2-pyrazoline derivatives on depression, anxiety and spontaneous locomotor activity parameters of mice. None of the compounds was effective ... -
An in vivo database model for pharmacological and physiological dosage for experimental animals
(Pergamon-Elsevier Science LTD, 2009)We developed a database compiling in vivo doses of compounds for various activities in certain animal species. The related database covers almost 100 years of experiments. The conceptual scheme of the database was created ...