Kurum Yazarı "Arslan, Rana" Makale Koleksiyonu İçin Listeleme
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Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid: Evidence for the importance of the 2-(o-substituted phenyl) group
Aydın, Süleyman; Arslan, Rana; Can, Özgür Devrim (2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1H-benzimidazole 5-carboxylic acid: evidence for the importance of the 2-(o-substituted phenyl) group
Aydın, Süleyman; Arslan, Rana; Can, Özgür Devrim (Govi-Verlag GMBH, 2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Antinociceptive effect of methanol extract of Capparis ovata in mice
Arslan, Rana; Bektaş, Nurcan (Taylor & Francis LTD, 2010)Context: Capparis ovata Desf. (Capparaceae) grows widely in Turkey. Flower buds and fruits of the plant are used in folk medicine for their analgesic, antirheumatismal, and diuretic effects. Objective:This study evaluated ... -
Antinociceptive, antiinflammatory, and antioxidant activities of the ethanol extract of Crataegus orientalis leaves
Bor, Zeynep; Arslan, Rana; Bektaş, Nurcan; Pirildar, Sevda; Dönmez, Ali Aslan (Tubitak Scientific & Technical Research Council Turkey, 2012)Aim: To determine the in vitro antioxidant activity and to investigate the possible antinociceptive and antiinflammatory effects of the ethanol extract of Crataegus orientalis leaves. The medicinal use of extracts prepared ... -
Antithrombotic effects of ethanol extract of Crataegus orientalis in the carrageenan-induced mice tail thrombosis model
Arslan, Rana; Bor, Zeynep; Bektaş, Nurcan; Meriçli, Ali Hikmet; Öztürk, Yusuf (Pergamon-Elsevier Science LTD, 2011)Introduction: Crataegus species (common name is Hawthorn) are medicinal plants, which have flavonoids, triterpene acids, proanthocyanidins, and organic acids as main constituents, used in the treatment of cardiovascular ... -
The Centrally-Mediated Mechanisms of Action of Ferulic Acid-Induced Antinociception
Bektaş, Nurcan; Arslan, Rana (Marmara University, Fac Medicine, 2016)This study aimed to investigate the central antinociceptive effects of ferulic acid, a common phenolic compound found in various medicinal plants used for pain relief, and the contribution of cholinergic, serotonergic, ... -
Dexketoprofen trometamol loaded solid lipid nanoparticles(SLNs): Formulation, in vitroand in vivoevaluation
Anadolu Üniversitesi, Eczacılık Fakültesi; 0000-0001-9596-0538; 0000-0002-7979-0089; 0000-0002-8041-6844; 0000-0001-9747-8307; 0000-0002-7492-1668; Öztürk, A. Alper; Yenilmez, Evrim; Arslan, Rana; Şenel, Behiye; Yazan, Yasemin (2020)Development, in vitroand in vivoevaluation of dexketoprofen trometamol (DT)-loaded nanosizeddrugdelivery system was aimed in this study. DT-loaded solid lipid nanoparticles (SLNs) were prepared using probe ... -
Evaluation of the Antidiabetic Property of Capparis Ovata Desf. Var. Palaestina Zoh. Extracts Using In vivo and In vitro Approaches
Okur, Mehmet Evren; Polat, Derya C.; Özbek, Hanefi; Yılmaz, Sezen; Yoltas, Ayşegül; Arslan, Rana (Bentham Science Publ LTD, 2018)Background and Objective: This paper is focused on evaluating the various biological activities of C. ovata var. palaestina extracts which could beneficially influence diabetes and its complications. Methods: Alloxan-induced ... -
Evaluation of the antithrombotic effects of Crataegus monogyna and Crataegus davisii in the carrageenan-induced tail thrombosis model
Arslan, Rana; Bektaş, Nurcan; Bor, Zeynep; Şener, Erol (Informa Healthcare, 2015)Context: Crataegus species are widely used as herbal medicines for preventing cardiovascular diseases (CVDs). However, there are no studies on the effects of Crataegus monogyna Jacq. (Rosaceae) and C. davisii Browicz on ... -
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract
Okur, Mehmet Evren; Özbek, Hanefi; Polat, Derya Çiçek; Yılmaz, Sezen; Arslan, Rana (University Sao Paulo, Conjunto Quimicas, 2018)Caper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant arc used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and ... -
The imidazoline receptors and ligands in pain modulations
Bektaş, Nurcan; Nemutlu, Dilara; Arslan, Rana (Wolters Kluwer Medknow Publications, 2015)Pain is an unpleasant experience and effects daily routine negatively. Although there are various drugs, many of them are not entirely successful in relieving pain, since pain modulation is a complex process involving ... -
Nepetalactone: A new opioid analgesic from Nepeta caesarea Boiss.
Aydın, Süleyman; Arslan, Rana; Öztürk, Yusuf; Başer, K. Hüsnü Can (Royal Pharmaceutical Soc Great Britain, 1998)The essential oils of Nepeta species including Nepeta phyllochlamys P. H. Davis, N. nuda L. ssp. nude, and N. caesarea Boiss. have been screened by use of the tail-flick and tail immersion (52.5 degrees C) methods. Of the ... -
Pharmacological and toxicological effects of gas plant (Dictamnus Albus L.)
Bu çalışmanın amacı Akgiritotu'nun farmakolojik ve toksikolojik etkilerini araştırmaktır. Yaprak ve meyvalarmdan hazırlanan sulu ekstreler kobay derisi üzerinde 2,4-dinitrobenzen ile karşılaştırmalı olarak test edilmiştir. ... -
The possible mechanisms of protocatechuic acid-induced central analgesia
Arslan, Rana; Aydın, Şule; Samur, Dilara Nemutlu; Bektaş, Nurcan (Elsevier Science BV, 2018)It is aimed to investigate the central antinociceptive effect of protocatechuic acid and the involvement of stimulation of opioidergic, serotonin 5-HT2A/2C. alpha 2-adrenergic and muscarinic receptors in protocatechuic ... -
The Role of TRP and K+ Ion Channels in Analgesic Effect of NSAIDs
Arslan, Rana; Bektaş, Nurcan (Marmara University, Inst Health Sciences, 2018)Objective: We aimed to clarify the possible contributions of TRP and voltage-dependent K+ channels to the analgesic effects of diclofenac, ketoprofen, etodolac, and dipyrone using the nonselective TRP channel blocker ... -
Valnoctamide: The effect on relieving of neuropathic pain and possible mechanisms
Samur, Dilara Nemutlu; Arslan, Rana; Aydın, Şule; Bektaş, Nurcan (Elsevier Science BV, 2018)The purpose of this study is to assess the possible anti-allodynic and antihyperalgesic effect of valnoctamide, an amide derivative of valproic acid, at the doses of 40, 70 and 100 mg/kg (i.p.) in neuropathic pain model ... -
Zonisamide: Antihyperalgesic efficacy, the role of serotonergic receptors on efficacy in a rat model for painful diabetic neuropathy
Bektaş, Nurcan; Arslan, Rana; Öztürk, Yusuf (Pergamon-Elsevier Science LTD, 2014)Aims: The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role ...