Ara
Toplam kayıt 132, listelenen: 1-10
Dexketoprofen trometamol loaded solid lipid nanoparticles(SLNs): Formulation, in vitroand in vivoevaluation
(2020)
Development, in vitroand in vivoevaluation of dexketoprofen trometamol (DT)-loaded nanosizeddrugdelivery system was aimed in this study. DT-loaded solid lipid nanoparticles (SLNs) were prepared using probe ...
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
(Elsevier Science BV, 2018)
The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ...
Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits
(Polish Acad Sciences Inst Pharmacology, 2012)
Background: In this study, benzothiazolc-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's ...
Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits
(Wiley, 2018)
ObjectivesThe objective of this study was to investigate the wound healing activity of Capparis ovata var. palaestina fruit extract in mice. For this aim, wound healing, invitro antimicrobial and antioxidant activities, ...
Opioid system mediated anti-nociceptive effect of agomelatine in mice
(Pergamon-Elsevier Science LTD, 2016)
Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these ...
Synthesis and antinociceptive activities of some novel benzimidazole-piperidine derivatives
(Scientific Technical Research Council Turkey-Tubitak, 2017)
In this study, a series of benzimidazole-piperidine derivatives were synthesized with the objective of developing potent antinociceptive agents. Some 2-(4-substituted-phenyl) 1 [2 (piperidin-1-yBethyl]-1 H-benzimidazole ...
Hypoglycemic activity of Capparis ovata desf. var. palaestina zoh. methanol extract
(University Sao Paulo, Conjunto Quimicas, 2018)
Caper (Capparis ovata Desf. and Capparis spinosa L.) is naturally widespread in Turkey. Traditionally, buds, fruits, seeds and roots of this plant arc used as tonic, diuretic, anti-rheumatic, expectorant, antidiabetic, and ...
Agmatine blocks ethanol-induced locomotor hyperactivity in male mice
(Elsevier Science BV, 2011)
Ethanol-induced locomotor activity is associated to rewarding effects of ethanol and ethanol dependence. Agmatine is a novel endogenous ligand at alpha(2)-adrenoceptors, imidazoline and N-methyl-D-aspartate (NMDA) receptors, ...
Frequency of angiotensin II type 1 receptor gene polymorphism in Turkish acute stroke patients
(Wiley, 2013)
This study was performed in acute stroke patients in the Turkish population to determine the frequency of the A1166C polymorphism in the AT1 gene and to examine the role of this polymorphism in acute stroke development. ...
The Involvement of NO-cGMP-ATP Sensitive K+ Channels Pathway in Protocatechuic Acid Peripheral Analgesia
(Assoc Pharmaceutical Teachers India, 2017)
Protocatechuic acid (PCA) is a widely distributed natural bioactive phenolic acid. The various pharmacological activities such as antioxidant, antidiabetic and anti-inflammatory activities have been identified. However, ...