Güncel Gönderiler: Makale Koleksiyonu
Toplam kayıt 132, listelenen: 21-40
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A computer experiment model to investigate the effects of drug dosage in animals, for use in pharmacological education and research
(2011)The ACD-IDEA database, which was originally developed by the authors in 2004, is an ongoing compilation of existing data on the in vivo doses of compounds at which various responses in certain animal species have been ... -
Reversal of experimental digoxin toxicity in rabbits using digoxin-specific antibodies
(1987)[No abstract available] -
The effect of vanadyl treatment on vascular responsiveness of streptozotocin-diabetic rats
(Springer-Verlag, 1994)Vanadyl sulphate has been demonstrated to possess insulin-like effects in streptozotocin (STZ) diabetic rats, including the normalization of hyperglycaemia and the prevention of diabetes-induced cardiac dysfunction. However, ... -
Basal and histamine-induced gastric acid secretion in alloxan diabetic rats
(1993)1. 1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. 2. Histamine-induced gastric acid secretion was found to be decreased ... -
Effect of lithium on gastro-intestinal complications in alloxan-diabetic rats
(1992)1. 1. Decreased ß-adrenergic and serotonergic responses have been reported in gastro-intestinal tract of experimentally diabetic rats. Effects of lithium on the decreased ß-adrenergic and serotonergic responsiveness of the ... -
Pharmacological effects of rutin
(1991)It is well-known that flavonoids including rutin exert a wide range of pharmacological effects. This study was carried out for further characterization of the pharmacological effect of rutin. A significant rise in the serum ... -
Beneficial effect of insulin on the decreased gastrointestinal ß-adrenergic responses in streptozotocin-diabetic rats: A contributing role of protein biosynthesis
(1992)The beneficial effect of insulin on the decreased gastrointestinal ß-adrenergic responses in experimentally diabetic rats has been reported. The effects of streptozotocin-induced diabetes and insulin on the isolated rat ... -
Investigation of signal transduction pathways involved in melanoma cell spreading
(2000)Integrins are a major family of heterodimeric adhesion receptors that are responsible for anchoring cells to extracellular matrix and they also can initiate intracellular signal pathways. Here parental and ?4-expressing ... -
New ß-diketone and 3,5-dimethyl isoxazole derivatives of theophylline as potential bronchodilator agents
(1998)Ten new compounds having 7-[(2,4-pentanedione-3-yl)alkyl]- and 7-[(3,5- dimethylisoxazole-4-yl)alkyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione structures were synthesized and their bronchodilator activities investigated ... -
Inhibitory effects of carvacrol on DMBA induced pulmonary tumorigenesis in rats
(1998)Essential oils of various plant species rich in carvacrol have several ethnomedical uses for various diseases in Turkey. Carvacrol, which was obtained by fractional distillation of Origanun onites L essential oil was tested ... -
Increased Alpha(1)-Adrenergic Responsiveness of Alloxan-Diabetic Rat Atria - Effects of Insulin Therapy and Thyroidectomy
(Pergamon-Elsevier Science LTD, 1994)1. Experimental models of diabetes are increasingly used for the investigation of cardiovascular complications as well as other complications due to diabetes mellitus. However, animal models have been used in relatively ... -
The Effects of Glyburide and Insulin on the Cardiac-Performance in Rats With Non-Insulin-Dependent Diabetes-Mellitus
(Pergamon-Elsevier Science LTD, 1993)1. The effects Of glyburide were studied on the myocardial contractile force and heart rate in the atria isolated from non-diabetic and non-insulin-dependent diabetic rats (diabetic). 2. In order to examine the myocardial ... -
Chronic heavy ethanol consumption is associated with decreased platelet aggregation in rats
(Tohoku University Medical Press, 2005)Although moderate alcohol consumption seems to be protective against atherosclerosis, coronary artery disease rate increases with its higher doses. Platelet aggregation is an important process which contributes to the ... -
Hypotensive effects of carvacrol on the blood pressure of normotensive rats
(Georg Thieme Verlag Kg, 2007)Carvacrol is the major compound of essential oils of many plants, ethnomedically used for centuries but there were no detailed investigations on its action on the cardiovascular system. The aim of our study was to investigate ... -
Composition of the essential oil of Cachrys alpina bieb.
(Allured Publ Corp, 2004)A hydrodistilled essential oil from fruits of Cachrysalpina,was analyzed by GUMS. Twenty-nine compounds representing 98% of the oil were identified with alpha-humulene (33.1%), p-cymene (9.3%). alpha-phellandrene (9.1%) ... -
Extract of Hypericum perforatum blocks caffeine-induced locomotor activity in mice: A possible role of nitric oxide
(John Wiley & Sons LTD, 2007)The present study investigated the effects of HPE on caffeine-induced locomotor activity in mice. Caffeine (416 mg/kg) or saline were given to adult male Swiss-Webster mice, and the locomotor activity was immediately ... -
MgSO 4 and lazaroid (U-83836E) partially protects glioma cells against glutamate toxidty in vitro
(2004)In this study, the possible effects of MgSO 4 and lazaroid (U-83836E) on glutamate toxicity on glial cells were investigated. C6 and human glioblastoma multiforme cells derived from two patients were grown in an incubator. ... -
Analgesic and antispasmodic activities of 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid: Evidence for the importance of the 2-(o-substituted phenyl) group
(2003)Benzimidazole 5-carboxylic acid derivatives were investigated for analgesic activity in this study. Of the benzimidazole compounds tested, 2-(2-nitro-phenyl)-1 H-benzimidazole 5-carboxylic acid showed remarkable naloxone ... -
Decreased Beta-Adrenergic Responses of Rat Small-Intestine Due to Non-Insulin-Dependent Diabetes
(Elsevier Sci Ireland LTD, 1990)…
