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dc.contributor.authorKipriye, Zeynep
dc.contributor.authorŞenel, Behiye
dc.contributor.authorYenilmez, Evrim
dc.date.accessioned2019-10-19T14:02:32Z
dc.date.available2019-10-19T14:02:32Z
dc.date.issued2017
dc.identifier.issn1596-5996
dc.identifier.urihttps://dx.doi.org/10.4314/tjpr.v16i9.4
dc.identifier.urihttps://hdl.handle.net/11421/12258
dc.descriptionWOS: 000418444300004en_US
dc.description.abstractPurpose: To develop suitable solid lipid nanoparticles (SLN) containing carvedilol (CL) for controlled delivery to site of action. Methods: Solid lipid nanoparticles (SLNs) containing carvedilol (CL) were prepared by hot homogenization and ultrasonication methods. The SLNs were characterized in terms of entrapment efficiency, particle size, zeta potential, polydispersity index, cytotoxicity, solid state characterization and drug release. The stability of the formulations was investigated by monitoring their properties for a period of 3 months. Results: The mean size of the nanoparticles was in the range of 130.70 +/- 1.80 to 154.40 +/- 2.40 nm. Solid state analysis showed that carvedilol was uniformly dispersed in the lipid nanoparticles. Drug entrapment efficiency ranged from 96.03 +/- 0.13 to 93.46 +/- 0.21 % while in vitro cumulative drug release from the nanoparticles in simulated intestinal fluid (SIF) and phosphate buffer containing 30% PEG (pH 6.8) was 96.57 +/- 0.40 and 75.13 +/- 0.15 %, respectively, at the end of 24 h. In vitro release of carvedilol from SLNs followed fist order kinetics and Higuchi diffusion model. Conclusion: The SLNs developed in this study represent a promising safe system for the sustained and controlled delivery of carvedilol.en_US
dc.description.sponsorshipAnadolu University Scientific Research Foundation [1502S061]en_US
dc.description.sponsorshipThis study was supported by Anadolu University Scientific Research Foundation (Project no. 1502S061).en_US
dc.language.isoengen_US
dc.publisherPharmacotherapy Groupen_US
dc.relation.isversionof10.4314/tjpr.v16i9.4en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarvedilolen_US
dc.subjectSolid Lipid Nanoparticlesen_US
dc.subjectAntihypertensiveen_US
dc.subjectSustained Releaseen_US
dc.titlePreparation and evaluation of carvedilol-loaded solid lipid nanoparticles for targeted drug deliveryen_US
dc.typearticleen_US
dc.relation.journalTropical Journal of Pharmaceutical Researchen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesien_US
dc.identifier.volume16en_US
dc.identifier.issue9en_US
dc.identifier.startpage2057en_US
dc.identifier.endpage2068en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorŞenel, Behiye


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