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dc.contributor.authorYeniceli, Duygu
dc.contributor.authorAk, Dilek
dc.contributor.authorTunçel, Muzaffer
dc.date.accessioned2019-10-19T14:02:44Z
dc.date.available2019-10-19T14:02:44Z
dc.date.issued2005
dc.identifier.issn1082-6076
dc.identifier.issn1520-572X
dc.identifier.urihttps://dx.doi.org/10.1081/JLC-200060448
dc.identifier.urihttps://hdl.handle.net/11421/12362
dc.descriptionWOS: 000230579400005en_US
dc.description.abstractA flow injection analysis (FIA) of leflunomide using UV-detection is described, in this study. The most suitable carrier solvent was found to be an aqueous solution of ethanol (25%, v/v). Leflunomide was determined at the optimum conditions, such as flow rate of 0.8 mL(.)min(-1) and detection wavelength of 260 nm. The method has been validated and linearity was examined in the range of 2.75 x 10(-6) - 1.10 X 10(-4) M. The limit of detection (LOD) and quantitation (LOQ) were calculated to be 2.60 x 10(-7) M (S/N = 3.3) and 7.87 x 10(-7) M (S/N = 10), respectively. The application of the proposed method has been performed in pharmaceutical tablets of leflunomide and excellent results were obtained. The results were compared with those obtained from UV-spectrophotometry. Insignificant difference was found between the methods. As a result, the FIA method for the determination of leflunomide in pharmaceutical tablets can be proposed as a precise, accurate, sensitive, and cheap method for routine analysis laboratories.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.isversionof10.1081/JLC-200060448en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeflunomideen_US
dc.subjectFlow-Injection Analysisen_US
dc.subjectPharmaceutical Analysisen_US
dc.titleDetermination of leflunomide in pharmaceutical tablets by flow-injection analysisen_US
dc.typearticleen_US
dc.relation.journalJournal of Liquid Chromatography & Related Technologiesen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalıen_US
dc.identifier.volume28en_US
dc.identifier.issue11en_US
dc.identifier.startpage1693en_US
dc.identifier.endpage1701en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorAk, Dilek
dc.contributor.institutionauthorTunçel, Muzaffer


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