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dc.contributor.authorYeniceli, Duygu
dc.contributor.authorAk, Dilek
dc.contributor.authorTunçel, Muzaffer
dc.date.accessioned2019-10-19T14:02:45Z
dc.date.available2019-10-19T14:02:45Z
dc.date.issued2006
dc.identifier.issn0731-7085
dc.identifier.issn1873-264X
dc.identifier.urihttps://dx.doi.org/10.1016/j.jpba.2005.06.030
dc.identifier.urihttps://hdl.handle.net/11421/12371
dc.descriptionWOS: 000234940300029en_US
dc.descriptionPubMed ID: 16112831en_US
dc.description.abstractIn the present study, a reverse phase high performance liquid chromatography (HPLC) method was validated and applied for the determination of leflunomide in tablets. Chromatographic separation of leflunomide and oxazepam as an internal standard was carried out on a C-18 column (50 mm, 3 mm i.d.) using a mobile phase, consisting of methanol and water (60:40, v/v), at a flow rate of 0.5 ml min(-1) and UV detection at 260 nm. The retention times for oxazepam and leflunomide were 2.6 and 5.2 min, respectively. The validated quantification range of the method was 2.7 x 10(-6) to 5.5 x 10(-5) M for leflunomide. The results of the developed procedure in tablets were compared with those of UV spectrophotometry to assess active leflunomide contenten_US
dc.language.isoengen_US
dc.publisherElsevier Science BVen_US
dc.relation.isversionof10.1016/j.jpba.2005.06.030en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeflunomideen_US
dc.subjectHplcen_US
dc.subjectTablet Analysisen_US
dc.subjectPharmaceuticalsen_US
dc.titleDetermination of leflunomide in tablets by high performance liquid chromatographyen_US
dc.typearticleen_US
dc.relation.journalJournal of Pharmaceutical and Biomedical Analysisen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalıen_US
dc.identifier.volume40en_US
dc.identifier.issue1en_US
dc.identifier.startpage197en_US
dc.identifier.endpage201en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorAk, Dilek
dc.contributor.institutionauthorTunçel, Muzaffer


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