| dc.contributor.author | Ak, Dilek | |
| dc.contributor.author | Banks, WA | |
| dc.contributor.author | Tuncel, N | |
| dc.contributor.author | Tunçel, Muzaffer | |
| dc.date.accessioned | 2019-10-19T14:02:46Z | |
| dc.date.available | 2019-10-19T14:02:46Z | |
| dc.date.issued | 2003 | |
| dc.identifier.issn | 0196-9781 | |
| dc.identifier.issn | 1873-5169 | |
| dc.identifier.uri | https://dx.doi.org/10.1016/S0196-9781(03)00059-7 | |
| dc.identifier.uri | https://hdl.handle.net/11421/12383 | |
| dc.description | WOS: 000183006100014 | en_US |
| dc.description | PubMed ID: 12732342 | en_US |
| dc.description.abstract | We investigated the ability of vasoactive intestinal peptide (VIP) to cross the blood-brain barrier (BBB), the interface between the peripheral circulation and central nervous system (CNS). VIP labeled with I-131 (I-VIP) and injected intravenously into mice was taken up by brain as determined by multiple-time regression analysis. Excess unlabeled VIP was unable to impede the entry of I-VIP, indicating that passage is by nonsaturable transmembrane diffusion. High pressure liquid chromatography (HPLC) showed the radioactivity entering the brain to be intact I-VIP. After intracerebroventricular (i.c.v.) injection, I-VIP was sequestered by brain, slowing its efflux from the CNS. In summary, VIP crosses the BBB unidirectionally from blood to brain by transmembrane diffusion | en_US |
| dc.description.sponsorship | NIAAA NIH HHS [R01 AA12743]; NINDS NIH HHS [R01 NS41863] | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Elsevier Science Inc | en_US |
| dc.relation.isversionof | 10.1016/S0196-9781(03)00059-7 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Vasoactive Intestinal Peptide | en_US |
| dc.subject | Blood-Brain Barrier | en_US |
| dc.subject | High-Performance Liquid Chromatography | en_US |
| dc.subject | Unidirectional Influx Rate | en_US |
| dc.subject | Cerebrospinal Fluid | en_US |
| dc.subject | Intracerebroventricular Injection | en_US |
| dc.title | Passage of vasoactive intestinal peptide across the blood-brain barrier | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Peptides | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalı | en_US |
| dc.identifier.volume | 24 | en_US |
| dc.identifier.issue | 3 | en_US |
| dc.identifier.startpage | 437 | en_US |
| dc.identifier.endpage | 444 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.institutionauthor | Ak, Dilek | |
| dc.contributor.institutionauthor | Tunçel, Muzaffer | |
