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dc.contributor.authorFarr, SA
dc.contributor.authorPoon, HF
dc.contributor.authorAk, Dilek
dc.contributor.authorDrake, J
dc.contributor.authorBanks, WA
dc.contributor.authorEyerman, E
dc.contributor.authorMorley, JE
dc.date.accessioned2019-10-19T14:02:49Z
dc.date.available2019-10-19T14:02:49Z
dc.date.issued2003
dc.identifier.issn0022-3042
dc.identifier.urihttps://dx.doi.org/10.1046/j.0022-3042.2003.01580.x
dc.identifier.urihttps://hdl.handle.net/11421/12401
dc.descriptionWOS: 000181055900026en_US
dc.descriptionPubMed ID: 12603840en_US
dc.description.abstractOxidative stress may play a crucial role in age-related neurodegenerative disorders. Here, we examined the ability of two antioxidants, alpha-lipoic acid (LA) and N -acetylcysteine (NAC), to reverse the cognitive deficits found in the SAMP8 mouse. By 12 months of age, this strain develops elevated levels of Abeta and severe deficits in learning and memory. We found that 12-month-old SAMP8 mice, in comparison with 4-month-old mice, had increased levels of protein carbonyls (an index of protein oxidation), increased TBARS (an index of lipid peroxidation) and a decrease in the weakly immobilized/strongly immobilized (W/S) ratio of the protein-specific spin label MAL-6 (an index of oxidation-induced conformational changes in synaptosomal membrane proteins). Chronic administration of either LA or NAC improved cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight. These effects probably occurred directly within the brain, as NAC crossed the blood-brain barrier and accumulated in the brain. Furthermore, treatment of 12-month-old SAMP8 mice with LA reversed all three indexes of oxidative stress. These results support the hypothesis that oxidative stress can lead to cognitive dysfunction and provide evidence for a therapeutic role for antioxidants.en_US
dc.description.sponsorshipNINDS NIH HHS [R01 NS 41863]; NIAAA NIH HHS [R01 AA 12743]en_US
dc.language.isoengen_US
dc.publisherBlackwell Publishing LTDen_US
dc.relation.isversionof10.1046/j.0022-3042.2003.01580.xen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectBlood-Brain Barrieren_US
dc.subjectLearningen_US
dc.subjectAlpha-Lipoic Aciden_US
dc.subjectOxidative Stressen_US
dc.subjectSamp8en_US
dc.titleThe antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 miceen_US
dc.typearticleen_US
dc.relation.journalJournal of Neurochemistryen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Analitik Kimya Anabilim Dalıen_US
dc.identifier.volume84en_US
dc.identifier.issue5en_US
dc.identifier.startpage1173en_US
dc.identifier.endpage1183en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorAk, Dilek


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