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dc.contributor.authorKıran, İsmail
dc.contributor.authorÖzşen, Özge
dc.contributor.authorÇelik, Turgay
dc.contributor.authorİlhan, Semra
dc.contributor.authorGürsu, Bukay Yenice
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2019-10-19T14:15:17Z
dc.date.available2019-10-19T14:15:17Z
dc.date.issued2013
dc.identifier.issn1934-578X
dc.identifier.urihttps://hdl.handle.net/11421/12736
dc.descriptionWOS: 000314617200017en_US
dc.descriptionPubMed ID: 23472460en_US
dc.description.abstractIsophorone (3,5,5-trimethyl-2-cyclohexen-1-one), a monoterpene, and the structurally related 1,8-cineole and camphor, have demonstrated a protective effect against cancer, biological activity against a variety of microorganisms, and anti-oxidant properties. The derivatization of isophorone is, therefore, an important field of xenobiochemistry, pharmacology and toxicology. The aim of this study was to obtain derivatives of isophorone through microbial biotransformation and evaluate the biotransformation metabolites as potential antimicrobial agents. Incubation of isophorone with the fungi Alternaria alternata and Neurospora crassa afforded 4 alpha-hydroxy- and 7-hydroxy-isophorone as transformation metabolites. The antimicrobial activities of isophorone and the metabolites were evaluated in vitro both by using agar dilution and microdilution methods. However, no significant antibacterial activity was observed when compared with those of standard substances.en_US
dc.description.sponsorshipEskisehir Osmangazi University Scientific Research Fund [200919015]en_US
dc.description.sponsorshipThis work was supported by the Eskisehir Osmangazi University Scientific Research Fund (Grant no: 200919015). The authors would like to thank MSc.Pharm. E. Civisov for his assistance, Dr A. Ozkirim (Hacettepe University, Ankara) for providing the N crassa strain and Chem. G. Saka (BIBAM, Anadolu University) for NMR analyses.en_US
dc.language.isoengen_US
dc.publisherNatural Products Incen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlternaria Alternataen_US
dc.subjectAntimicrobial Evaluationen_US
dc.subjectBiotransformationen_US
dc.subjectIsophoroneen_US
dc.subjectMicen_US
dc.subjectNeurospora Crassaen_US
dc.titleMicrobial Transformations of Isophorone by Alternaria alternata and Neurospora crassaen_US
dc.typearticleen_US
dc.relation.journalNatural Product Communicationsen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalıen_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.startpage59en_US
dc.identifier.endpage61en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorDemirci, Fatih


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