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dc.contributor.authorÖzek, Gülmira
dc.contributor.authorIshmuratova, Margarita
dc.contributor.authorYur, Süleyman
dc.contributor.authorGöğer, Fatih
dc.contributor.authorHaliloğlu, Yeşim
dc.contributor.authorBaşer, K. Hüsnü Can
dc.contributor.authorÖzek, Temel
dc.date.accessioned2019-10-19T14:15:29Z
dc.date.available2019-10-19T14:15:29Z
dc.date.issued2017
dc.identifier.issn1934-578X
dc.identifier.issn1555-9475
dc.identifier.urihttps://hdl.handle.net/11421/12856
dc.descriptionInternational Symposium on Natural Products for the Future (ISNPF) -- OCT 01-04, 2016 -- Tokushima Bunri Univ, Tokushima, JAPANen_US
dc.descriptionWOS: 000408399600029en_US
dc.description.abstractIn the present work two Galatella species, Galatella villosa Rchb.f. and Galatella tatarica (Less.) Novopokr collected from Kazakhstan were subjected to hydrodistillation to yield essential oils (EOs), and to maceration in methanol to yield extracts (MEs). The EOs and MEs were evaluated for antioxidant and in vitro inhibitory activities against alpha-amylase, tyrosinase, lipoxygenase and xanthine oxidase enzymes. The EOs of G. villosa and G. tatarica were investigated for chemical composition using GC-FID and GC/MS techniques. The composition of MEs was investigated with LC-MS/MS technique. Monoterpenes, beta-pinene (23.6 %) and alpha-pinene (14.4 %) were the main constituents of G. tatarica essential oil, while the oil of G. villosa was characterized not only with monoterpene alpha-pinene (9.0 %), but also fatty acid, hexadecanoic acid (10.2%). 3-, 5-, 1,5- and 3,4-caffeoylquinic acids, 3-, 4- and 5-feruloylquinic acids, quercetin and its different glycosides were detected in MEs according to mass spectral data. G. tatarica (IC50=74.3 mu g/mL) and G. villosa (IC50=78.5 mu g/mL) extracts showed significant antioxidant activity. In the beta-carotene bleaching test, the extracts demonstrated noteworthy activity (%Inh 44.46 and 41.14). The extracts scavenged ABTS radical as 1.85 mM and 1.27 mM of Trolox. In a concentration of 0.5 mg/mL, the oils showed 89% and 85% inhibition of alpha-amylase, while the extracts showed 86% and 78% inhibition at 2 mg/mL concentration, respectively. The EOs demonstrated noteworthy potent LOX enzyme inhibition ranging between 45% and 57%. In xanthine-xanthine oxidase model system, the extracts demonstrated the highest inhibitory potency ranging between 43% and 39%. The present work is the first contribution to the chemistry and biological activities of G. tatarica and G. villosa.en_US
dc.description.sponsorshipPhytochem Soc Asia, Nat Prod Communen_US
dc.language.isoengen_US
dc.publisherNatural Products Incen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGalatella Villosaen_US
dc.subjectGalatella Tataricaen_US
dc.subjectGc/Msen_US
dc.subjectLc-Ms/Msen_US
dc.subjectAntioxidanten_US
dc.subjectAlpha-Amylaseen_US
dc.subjectTyrosinaseen_US
dc.subjectLipoxygenaseen_US
dc.subjectXanthine Oxidaseen_US
dc.titleInvestigation of Galatella villosa and G. tatarica for Antioxidant, alpha-Amylase, Tyrosinase, Lipoxygenase and Xanthine Oxidase Inhibitory Activitiesen_US
dc.typeconferenceObjecten_US
dc.relation.journalNatural Product Communicationsen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalıen_US
dc.identifier.volume12en_US
dc.identifier.issue8en_US
dc.identifier.startpage1255en_US
dc.identifier.endpage1258en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorÖzek, Gülmira
dc.contributor.institutionauthorGöğer, Fatih
dc.contributor.institutionauthorBaşer, K. Hüsnü Can
dc.contributor.institutionauthorÖzek, Temel


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