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dc.contributor.authorTabanca, Nurhayat
dc.contributor.authorBedir, E
dc.contributor.authorFerreira, D
dc.contributor.authorSlade, D
dc.contributor.authorWedge, David E.
dc.contributor.authorJacob, Melissa R.
dc.contributor.authorKhan, Ikhlas A.
dc.date.accessioned2019-10-19T14:15:56Z
dc.date.available2019-10-19T14:15:56Z
dc.date.issued2005
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.urihttps://dx.doi.org/10.1002/cbdv.200590005
dc.identifier.urihttps://hdl.handle.net/11421/13019
dc.descriptionWOS: 000227596300006en_US
dc.descriptionPubMed ID: 17191975en_US
dc.description.abstractA new 'phenylpropanoid', 4-(3-methyloxiran-2-yl)phenyl 2-methylbutanoate (1), a new trinorsesquiterpene, 4-(6-methylbicyclo[4.1.0]hept-2-en-7-yl)butan-2-one (2), and eight known compounds (3-10) were isolated from the essential oils of several Pimpinella species growing in Turkey. The structures of the new compounds were determined by 1D- and 2D-NMR analyses. The absolute configuration of 1 was established via comparison of its optical rotation with that of 'epoxypseudoisoeugenyl 2-methylbutyrate' (11), the absolute configuration of which was determined by chemical degradation and an appropriate Mosher ester formation. Direct bioautography revealed antifungal activity of I and 11 against Colletotrichum acutatum, C. fragariae, and C gloesporioides. Subsequent evaluation of antifungal compounds in a 96-well microtiter assay showed that compounds 1 and 11 produced the most-significant growth inhibition in Phomopsis spp., Colletotrichum spp., and Botrytis cinerea. Compounds 1 and 6 displayed antimicrobial activities against Mycobacterium intra-cellulare, with IC50 values of 2.78 and 1.29 mu M, respectively.en_US
dc.language.isoengen_US
dc.publisherWiley-V C H Verlag GMBHen_US
dc.relation.isversionof10.1002/cbdv.200590005en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleBioactive constituents from Turkish Pimpinella speciesen_US
dc.typearticleen_US
dc.relation.journalChemistry & Biodiversityen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalıen_US
dc.identifier.volume2en_US
dc.identifier.issue2en_US
dc.identifier.startpage221en_US
dc.identifier.endpage232en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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