Antimicrobial compounds from Pimpinella species growing in Turkey

Abstract

A new, 4-(2-propenyl)-phenyl angelate (1) and four known phenylpropanoids (2-5), were isolated from Pimpinella isaurica, a species endemic in Turkey. One new sesquiterpene, 1-methyl-4-(5-methyl-1-methylenehex-4-enyl)-7-oxabicyclo[4.1.0]heptane (6) was obtained from P. aurea and two known phenylpropanoids were isolated (7, 8), from P. corymbosa. The structure elucidation of the new compounds 1 and 6 was achieved by a combination of one- (H-1, and C-13) and two-dimensional NMR techniques (G-DQF-COSY, G-HMQC, and G-HMBC, and LC-ESI-FTMS. Compounds 1, 2, 4, 6, 7, 8 have been evaluated for their antimalarial and antimicrobial activities. Compound 1, 2, 4, 6, 8 had antimicrobial activity against Mycobacterium intracellulare with IC50 values of 7.0,15.0, 2.5, 10.0 and 1.5 mug/mL, respectively.