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dc.contributor.authorYumrutas, O.
dc.contributor.authorÖztuzcu, S.
dc.contributor.authorPehlivan, M.
dc.contributor.authorÖztürk, Nilgün
dc.contributor.authorEröz Poyraz, İlham
dc.contributor.authorIğci, Y. Z.
dc.contributor.authorArslan, A.
dc.date.accessioned2019-10-19T14:16:15Z
dc.date.available2019-10-19T14:16:15Z
dc.date.issued2015
dc.identifier.issn2231-3354
dc.identifier.urihttps://dx.doi.org/10.7324/JAPS.2015.50301
dc.identifier.urihttps://hdl.handle.net/11421/13109
dc.description.abstractThe breast cancer is one of the most common types of cancer. Many scientists have focused on the treatment of this disease for a long time by studying anti-cancer activities of plant extracts as well as synthetics. Lamiaceae and Asteraceae have been used in anticancer studies due to their phytochemical content. The genus Sideritis, Achillea and Tanacetumare the members of these families. Sideritis, Achillea and Tanacetum are used as herbal medication for the treatment ofvariety of diseases. In present study, we demonstrated the biological activity of Sideritis syriaca (SS), Achillea aleppica (AAZ) and Tanacetum argenteum (TAA) methanol extracts on cell viability of the breast cancer line MCF7. MTT (3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to determine the cell viability and proliferation of MCF7 cells. In a dose dependent manner, methanol extracts (0, 1, 5, 25, 100 and 250 µg/ml) of SS, AZZ and TAA were examined on MCF7, and viability of cells were determined with MTT staining. Especially, concentrations in 100 and 250 µg/ml of extracts decreased the cell viability (p<0.001). The results of the current study showed that methanol extracts of SS, AZZ and TAA effectively inhibited the cell proliferation by decreasing the cell viability of MCF7 cells. Suggesting that SS, AZZ and TAA can be considered as natural herbal-based anti-cancerous agentsen_US
dc.language.isoengen_US
dc.publisherOpen Science Publishers LLP Inc.en_US
dc.relation.isversionof10.7324/JAPS.2015.50301en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAchilleaen_US
dc.subjectAntioxidanten_US
dc.subjectAntiproliferationen_US
dc.subjectCancer Cell Lineen_US
dc.subjectCell Viabilityen_US
dc.subjectSideritisen_US
dc.subjectTanacetumen_US
dc.titleCell viability, anti-proliferation and antioxidant activities of Sideritis syriaca, Tanacetum argenteum sub sp. argenteum and Achillea aleppica subsp. zederbaueri on human breast cancer cell line (MCF-7)en_US
dc.typearticleen_US
dc.relation.journalJournal of Applied Pharmaceutical Scienceen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalıen_US
dc.identifier.volume5en_US
dc.identifier.issue3en_US
dc.identifier.startpage1en_US
dc.identifier.endpage5en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorÖztürk, Nilgün
dc.contributor.institutionauthorEröz Poyraz, İlham


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