Browsing Farmasötik Kimya Anabilim Dalı by Title
Now showing items 17-36 of 345
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Antimicrobial evaluation of trisubstituted 2-piperazinyl thiazoles
(İstanbul Medipol University, 2019)Thiazole and basic nitrogen containing rings are important chemical moieties of antimicrobial drugs. In recent, third generation cephalosporins include thiazole ring system. In this study, we synthesized 33 piperazine ... -
Antiproliferative effects of some N-benzylideneanilines
(John Wiley & Sons LTD, 2008)A series of Schiff bases including N-benzylideneaniline (NBA) nuclei were prepared. The chemical products obtained were characterized by mass spectometry (APCI), H-1 NMR, and IR spectroscopy in order to seek their cytotoxic ... -
Antiproliferative, Cytotoxic, and Apoptotic Effects of New Benzimidazole Derivatives Bearing Hydrazone Moiety
(Wiley, 2018)In order to take the advantages of the anticancer properties of benzimidazoles and hydrazones, we synthesized new 4-(5-chloro-1H-benzimidazol-2-yl)-benzoic acid benzylidene hydrazide derivatives (3a-3t) and evaluated their ... -
Antitumor and calcium mobilisation activities of 1,4 bis-(heteroaryl substituted)benzene (BHB) derivatives on U2OS cells
(Blackwell Publishing, 2006)… -
Apoptotic effects of dipyrido [3,2-a:2 ',3 '-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats
(Springer, 2014)We evaluated the effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex ([Au(dppz)Cl-2]Cl) on apoptosis during chemically induced hepatocellular carcinoma. 48 male Spraque-Dawley rats were divided into six ... -
Bazı İmidazo[1,2-a]pirazin Türevlerinin Sentezi ve Antinosiseptif Aktivitelerinin Değerlendirilmeleri
(2016)Amaç: İmidazopirazin halkası biyolojik olarak aktif bir heterosiklik halkadır. Bir dizi hidrazid-hidrazon türevi bileşiğin antibakteryial-antifungal, antikonvülzan, antiinflamatuvar, antitüberkülotik ve analjezik aktiviteye ... -
Benzimidazol derivatives: Synthesis, antibacterial activity and QSARs of some 2-alkyl-5-chloro-benzimidazoles
(1989)[No abstract available] -
Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
(Bentham Science Publ LTD, 2017)Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ... -
Biological activity of some 4,5-di and 2,4,5-trisubstituted imidazole derivatives: Antihelmintic activity
(1988)[No abstract available] -
Biological evaluation of a series of benzothiazole derivatives as mosquitocidal agents
(Sciendo, 2019)Aedes aegypti is associated with the transmission of numerous human and animal diseases, such as yellow fever, dengue fever, chikungunya, and more recently Zika virus. Emerging insecticide resistance has created a need to ... -
Carbazoles and Hydrazone-Bridged Thiazole-Pyrrole Derivatives as New Inhibitors of alpha-Glucosidase
(Wiley-V C H Verlag GMBH, 2018)Carbazoles and hydrazone-bridged thiazole-pyrrole derivatives are known to exhibit a wide range of biological activities including antimicrobial activity. This work is a further extension of their biological activities ... -
Comparative studies on conventional and microwave-assisted synthesis of a series of 2,4-di and 2,3,4-trisubstituted benzimidazol[1,2-a] pyrimidines and their antimicrobial activities
(Versita, 2009)Comparative studies were performed on a series of 2,41-di and 2,3,4-trisubstituted benzimidazo[1,2-a]pyrimidines, which were synthesized with conventional and microwave heating methods. In microwave irradiation method, ... -
Composition of the essential oil of Cistus laurifolius L. from Turkey
(Allured Publ Corp, 2004)The water distilled essential oil of Cistus laurifolius L. from Turkey was analyzed by GC/MS. Sixty four compounds representing 67% of the oil were identified. Borneol (6.1%) and nonacosane (2.8%) were the major constituents. -
Composition of the essential oil of Cistus parviflorus L. from Turkey
(Allured Publ Corp, 2004)ater distilled essential oil of Cistus parviflorus L. from Turkey was analyzed by GC/MS. Seventy-six representing 89.4% of the oil were identified. 8-alpha-13-oxy-14-ene-epilabdane (18.2%), manoyl oxide (9.1%) and ... -
Crystal structure of [1-(1H-benzoimidazol-2-yl)-ethanone thiosemicarbazone]2nickel, [C20H22N10S2Ni]
(Japan Society for Analytical Chemistry, 2005)The title compound, [C20H22N10S2Ni], crystallizes in the triclinic space group P1 with cell parameters a = 10.9319(9)Å, b = 12.0083(9)Å, c = 13.4978(11)Å, ? = 87.057(7)°, ß = 85.841(7)°, ? = 63.820 (6), V = 1585.6(2)Å3, Z ... -
Cytotoxic and genotoxic effects of [Ru(phi)(3)](2+) evaluated by Ames/Salmonella and MTT methods
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)In this work, we synthesized and evaluated the cytotoxic effect of [Ru(phi)(3)](2+), on rat C6 glioma cell line. Cell viability was determined by assay with 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide ... -
Cytotoxic effects of some perimidine derivatives on F2408 and 5Rp7 cell lines
(2008)In this study twenty perimidine derivatives were prepared in order to seek their cytotoxic and antiproliferative effects on normal rat embryo fibroblast (F2408) and carcinogenic rat embryo fibroblast (5RP7) cell lines. ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
(Bentham Science Publ LTD, 2015)Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a ...