Başlık için Farmasötik Kimya Anabilim Dalı listeleme
Toplam kayıt 345, listelenen: 97-116
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QSAR of smooth muscle relaxation by 2,5-substituted-benzimidazole derivatives
(1997)Quantitative structure-activity anlayses were carried out for in vitro relaxant actions of a series of 2,5-substituted-benzimidazoles in rat duodenal smooth muscle. Analyses of simple and multiple linear regression models ... -
QSAR studies on anticancer activities of some 6,8-diarylimidazo[1,2-a]pyrazine derivatives
(Prous Science, Sa, 2007)… -
Some 1-substituted 3-aryl-1,4-dihydro-1,2,4-triazino[4,3-a]- benzimidazoles and their vasodilatory activities
(Societa Chimica Italiana, 1997)In this study, some 1-substituted 3-aryl-1,4-dihydro-1,2,4- triazino[4,3-a]benzimidazole derivatives were synthesized, their structures were elucidated, and their vasodilatory activities were examined. It was found that ... -
Some 3-alkyl-6-(2-aryl-2-oxo-1-ethyl)-7-oxothiazolo [4,5-d]pyrimidin-2(3H)-thione derivatives and their antimicrobial activities
(2005)In this study, some 3-alkyl-6-(2-aryl-2-oxo-1-ethyl)-7-oxothiazolo [4,5-d]pyrimidin-2(3H)-thione derivatives have been synthesized by reacting 3-alkyl-7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thiones with various ?-bromoacetophenones. ... -
Some 6-substituted 3-aryl-7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thione derivatives and their antimicrobial activities
(Taylor & Francis LTD, 2007)In this study, 3-aryl-6-substituted thiazolopyrimidin-2(3H)-thione derivatives 4 and 6 have been synthesized by reacting thiazolopyrimidines 2 with omega-bromoacetophenone 3 and 2-chloro-N-(2-thiazolyl)acetamides 5. The ... -
Some new 2,3-dihydro-3 benzofuranamine derivatives
(1998)In this study, four series of the compounds (i.e. 2, 3, 4 and 5) were synthesized using the 2-chloro-N-(2,3-dihydro-3-benzofuryl)acetamides. The structures of the compounds were elucidated by IR, 1H-NMR, MASS spectroscopy ... -
Some new 4-aryl-2-thiazolylhydrazones
(1997)In this study, three series of 4-aryl-2-thiazolylhydrazones were synthesized using three different thiosemicarbazones. Structures of the compounds were elucidated by IR, 1H NMR and elemental analysis. The prepared compounds ... -
Some pyridazinone and phthalazinone derivatives and their vasodilator activities
(Pharmaceutical Society of Korea, 2004)In this study, 6-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5- dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl) phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting ... -
Some pyrrole substituted aryl pyridazinone and phthalazinone derivatives and their antihypertensive activities
(2004)In this work, some 2-nonsubstituted/2-methyl-/2-(2-acetyloxyethyl)-6-[4- (substituted pyrrol-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone, derivatives and 2-nonsubstituted/2-methyl- 4-[4-(substituted pyrrol-1-yl)phenyl]-1(2H)- ... -
Some Thiazole Derivatives Combined with Different Heterocycles: Cytotoxicity Evaluation and Apoptosis Inducing Studies
(Bentham Science Publ LTD, 2018)Background: Thiazole ring is an outstanding structure found in many biologically active compounds and clinically available drugs. Because of synthesis simplicity of its derivatives and having a wide range of biological ... -
Some thiazolylaminopyrrole derivatives and their antimicrobial activity
(1999)In this study, some ethyl 1-(4-arylthiazol-2-yl)amino-2-methyl-5-aryl-1H-pyrrole-3-carboxylic acid derivatives were obtained by reacting 1-(2-methyl-3-carbethoxy-5-arylpyrrol-1-yl)thioureas with ?-bromoacetophenone ... -
Spectroscopic Determination and Evaluation of Acidity Constants for Some Drug Precursor 2-Amino-4-(3-or 4-substituted phenyl) Thiazole Derivatives
(American Chemical Society, 2010)Acid dissociation constants, K(a), of eight drug precursor 2-amino-4-(3- or 4-substituted phenyl) thiazole derivatives were determined using a UV-vis spectroscopic technique. The obtained K(a) values were evaluated by ... -
Studies of the synthesis of some 4,5-di and 2,4,5-trisubstituted imidazole derivatives
(1989)[No abstract available] -
Studies on 1,2,4-triazole derivatives as potential anti-inflammatory agents
(Wiley-V C H Verlag GMBH, 2007)The reaction of acetic or propionic acid hydrazides with various aryl/alkyl isothiocyanates gave thiosemicarbazides which furnished the 1,2,4-triazoles by alkali cyclization. The 4-aryl/allcyl-5-(1phenoxyethyl)-3-[N-(sub ... -
Studies on hydrazide-hydrazones derivatives as acetylcholinesterase inhibitors
(Aves Press LTD, 2015)Objective: Fifteen hidrazide-hydrazone derivatives were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) using a modification of Ellman's spectrophotometric method. Methods: Anti-acetylc ... -
Studies on hydrazone derivatives as antifungal agents
(Taylor & Francis LTD, 2008)The increasing clinical importance of drug-resistant fungal pathogens has urged additional need to fungal research and new antifungal compound development. For this purpose, some N-(1-benzyl-2-phenylethylidene)-N'-[4-(ar ... -
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives
(Pergamon-Elsevier Science LTD, 2018)Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their ... -
Studies on some new pyrazolo[3,4-c]pyridine derivatives as antimicrobial agents [Antimikrobiyal ajan olarak bazi yeni pirazolo[3,4-c]piridin türevleri üzerine çahsmalar]
(2009)The increasing clinical importance of drug-resistant bacterial and fungal pathogens has lent additional urgency to microbiological research and novel antimicrobial compounds development. For this aim, a series of N-[(Benzhydryl) ... -
Studies on the determination of the physicochemical parameters of some commercially available sulfonamide drugs in Turkey
(1995)[No abstract available] -
Studies on the ionisation constants and copper complex of 2-aminomethylbenzimidazole and its 5-nitro derivative
(1991)[No abstract available]
