Kurum Yazarı "Sağlık, Begüm Nurpelin" Farmasötik Kimya Anabilim Dalı İçin Listeleme
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Anticholinesterase activity screening of some novel dithiocarbamate derivatives including piperidine and piperazine moieties
Levent, Serkan; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Can, Özgür Devrim; Özkay, Ümide Demir; Uçucu, Ümit (Taylor & Francis LTD, 2017)The present study was undertaken to synthesize some novel lipophilic piperazine and piperidinedithiocarbamates and investigate their inhibitory potencies against cholinesterase enzymes. In the synthetic studies, 44 new ... -
Antiproliferative, Cytotoxic, and Apoptotic Effects of New Benzimidazole Derivatives Bearing Hydrazone Moiety
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Korkut, Büşra; Özkay, Yusuf; Ilgın, Sinem (Wiley, 2018)In order to take the advantages of the anticancer properties of benzimidazoles and hydrazones, we synthesized new 4-(5-chloro-1H-benzimidazol-2-yl)-benzoic acid benzylidene hydrazide derivatives (3a-3t) and evaluated their ... -
Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
Yurttaş, Leyla; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Sağlık, Begüm Nurpelin; Demir, Bahar; Levent, Serkan (Bentham Science Publ LTD, 2017)Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ... -
Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
Turan, Gülhan; Hussein, Weiam; Sağlık, Begüm Nurpelin; Tabbi, Aouatef; Korkut, Büşra (MDPI, 2018)A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The ... -
Design, synthesis, monoamine oxidase inhibition and docking studies of new dithiocarbamate derivatives bearing benzylamine moiety
Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Özkay, Yusuf; İnci, Beril; Kaplancıklı, Zafer Asım (Academic Press Inc Elsevier Science, 2018)A new series of thirteen 2-[(4-fluorophenyl)(4-nitrobenzyl) amino]-2-oxoethyl-1-substituted-carbodithio ate derivatives (4a-4m) were synthesized and tested for their human monoamine oxidase A and B (hMAO-A and hMAO-B) ... -
Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors
Turan, Gülhan; Hussein, Weiam; Sağlık, Begüm Nurpelin; Baysal, Merve; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language ability and other cognitive deterioration, ... -
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
Sağlık, Begüm Nurpelin; Kaya Çavuşoğlu, Betül; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Ilgın, Sinem; Öztürk, Yusuf (Academic Press Inc Elsevier Science, 2019)New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to determine the biological effects of synthesized ... -
Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
Kaya, Betül; Yurttaş, Leyla; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2017)In the present study, a new series of 2-[4-(pyrimidin-2-yl) piperazin-1-yl]-2-oxoethyl 4-substituted piperazine- 1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory ... -
Novel imidazole derivatives as antifungal agents: Synthesis, biological evaluation, ADME prediction and molecular docking studies
Altındağ, Firuze Diyar; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Işıkdağ, İlhan; Özkay, Yusuf; Karaca Gencer, Hülya (Taylor & Francis LTD, 2019)A series of 2-(substituteddithiocarbamoyl)-N-[4-((1H-imidazol-1-yl)methyl)phenyl]acetamide derivatives was designed and synthesized to combat the increasing incidence of drug-resistant fungal infections. All synthesized ... -
Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
Osmaniye, Derya; Sağlık, Begüm Nurpelin; Acar Çevik, Ulviye; Levent, Serkan; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Turan, Gülhan (MDPI, 2019)Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life ... -
Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Levent, Serkan; Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2019)Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly ... -
Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
Kaplancıklı, Zafer Asım; Levent, Serkan; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Ilgın, Sinem (MDPI, 2017)Azole-based antifungal agents constitute one of the important classes of antifungal drugs. Hence, in the present work, 12 new benzimidazole-thiazole derivatives 3a-3l were synthesized to evaluate their anticandidal activity ... -
Synthesis and Anticandidal Activity of New Imidazole-Chalcones
Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI, 2018)In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl) prop-2-en-1-one derivatives (3a-3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole ... -
Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
Karaburun, Ahmet Çağrı; Kaya Çavuşoğlu, Betül; Çevik, Ulviye Acar; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Levent, Serkan; Kaplancıklı, Zafer Asım (MDPI, 2019)Discovery of novel anticandidal agents with clarified mechanisms of action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to existing drugs. In support to this ... -
Synthesis and antimicrobial activities of some novel thiazole compounds
Turan, Gülhan; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar (Walter De Gruyter GMBH, 2018)Objective: The advent of resistant pathogenic microorganisms against current antimicrobial drugs prompted scientists to investigate novel molecules with new mechanisms. In this paper, some new 2-[2-[4-(ethyl/phenyl)cyclo ... -
Synthesis and antimicrobial activity of new 2-((1-furan-2-yl)ethylidene)hydrazono)-4-phenylthiazol-3(2H)-amine derivatives and their schiff bases with 4-nitrobenzaldehyde
Turan, Gülhan; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Levent, Serkan; Ilgın, Sinem; Hussein, Weiam (Taylor & Francis LTD, 2018)A new series of 2-((1-furan-2-yl)ethylidene)hydrazono)-4-substitutedphenylthiazol-3(2H)-amines (2a-2o) and their Schiff bases (3a-3o) from 4-nitrobenzaldehyde were synthesized. The chemical structures of all the synthesized ... -
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease
Hussein, Weiam; Sağlık, Begüm Nurpelin; Levent, Serkan; Korkut, Büsra; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the ... -
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
Tok, Fatih; Koçyiğit-Kaymakçıoğlu, Bedia; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Academic Press Inc Elsevier Science, 2019)In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, H-1 NMR, C-13 NMR and mass spectroscopies. The inhibitory potency of ... -
Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Karaduman, Abdullah Burak; Kaplancıklı, Zafer Asım (MDPI, 2018)Twenty-six novel thiosemicarbazone derivative B1-B26 were synthesized via condensation reactions between the corresponding thiosemicarbazides and aldehydes. The chemical characterization of the compounds was carried out ... -
Synthesis and Biological Evaluation of Some Novel Dithiocarbamate Derivatives
Sağlık, Begüm Nurpelin; Özkay, Yusuf; Özkay, Ümide Demir; Karaca Gencer, Hülya (Hindawi LTD, 2014)18 novel dithiocarbamate derivatives were synthesized in order to investigate their inhibitory potency on acetylcholinesterase enzyme and antimicrobial activity. Structures of the synthesized compounds were elucidated by ...