Kurum Yazarı "Temel, Halide Edip" Farmasötik Kimya Anabilim Dalı İçin Listeleme
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Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
Yurttaş, Leyla; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Sağlık, Begüm Nurpelin; Demir, Bahar; Levent, Serkan (Bentham Science Publ LTD, 2017)Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ... -
New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation
Turan, Gülhan; Yurttaş, Leyla; Tabbi, Aouatef; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Kaplancıklı, Zafer Asım (MDPI AG, 2018)In this study, novel N-(3-cyclohexyl/phenyl-4-(substituted phenyl)thiazole-2(3H)-ylidene)-2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetohydrazide (4a-4k) derivatives were synthesized and their anticancer potency were ... -
Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
Yurttaş, Leyla; Ertaş, Merve; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Demirayak, Şeref (University of Istanbul, 2017)In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against ... -
Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Walter De Gruyter GMBH, 2017)Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme ... -
Synthesis and Anticholinesterase Activity and Cytotoxicity of Novel Amide Derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Temel, Halide Edip; Akalın Çiftçi, Gülsen (Wiley-V C H Verlag GMBH, 2012)In the present study, some amide derivatives were synthesized and their potential anticholinesterase properties were investigated. N-(Benzothiazol-2-yl)-2-[(5-amino/methyl-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives ... -
Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors
Yurttaş, Leyla; Kaya Çavuşoğlu, Betül; Çiftçi, Gülsen Akalın; Temel, Halide Edip (Bentham Science Publ LTD, 2018)Background: 1,3,4-Oxadiazoles have been known with a wide variety of pharmacological activities including anticancer activity. Objective: In this study, novel 2,5-disubstituted 1,3,4-oxadiazole derivatives were synthesized ... -
Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone Derivatives
Kaya, Betül; Özkay, Yusuf; Temel, Halide Edip; Kaplancıklı, Zafer Asım (Hindawi LTD, 2016)Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N'-(2,4-disubstitutedbenzylidene)-2-(4-(4-nitrophenyl)piperazin-1-yl)acetohydrazide ... -
Synthesis and Biological Evaluation of Some Pyrazoline Derivatives Bearing a Dithiocarbamate Moiety as New Cholinesterase Inhibitors
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Turan, Gülhan; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Wiley-V C H Verlag GMBH, 2013)In the present study, new pyrazoline derivatives were synthesized via the reaction of 1-(chloroacetyl)-3-(2-furyl)-5-aryl-2-pyrazolines with sodium salts of N,N-disubstituted dithiocarbamic acids. Each derivative was ... -
Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors
Turan, Gülhan; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Informa Healthcare, 2013)In the present study, some thiazole derivatives were synthesized via the ring closure reaction of 1-[2-(2-oxobenzo[d] thiazol-3(2H)-yl)acetyl]thiosemicarbazide with various phenacyl bromides. The chemical structures of the ... -
Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Sever, Belgin; Baysal, Merve; Temel, Halide Edip; Özdemir, Ahmet (Bentham Science Publ LTD, 2017)Background: In recent years, the relationship between overexpression of matrix metalloproteinases ( MMPs) and tumor invasion/metastasis has prompted researchers to develop MMP inhibitors as anticancer drugs. Objective: The ... -
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Çiftçi, Gülsen Akalın; Temel, Halide Edip (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New bis-thiazole derivatives (1-10) were synthesized via the ring closure of 1,1'-(3,3'-dimethoxybipheny1-4,4'-diyl)bis(thiourea) with phenacyl bromides and evaluated for their cytotoxic effects on A549 human lung ... -
Synthesis and Evaluation of New Benzodioxole-Based Thiosemicarbazone Derivatives as Potential Antitumor Agents
Altıntop, Mehlika Dilek; Temel, Halide Edip; Sever, Belgin; Çiftçi, Gülsen Akalın; Kaplancıklı, Zafer Asım (MDPI, 2016)New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cells. In order to ... -
Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Temel, Halide Edip; Atlı Eklioğlu, Özlem; Baysal, Merve; Demirci, Fatih (MDPI, 2017)Matrix metalloproteinases (MMPs) are important proteases involved in tumor progression including angiogenesis, tissue invasion, and migration. Therefore, MMPs have been reported as potential diagnostic and prognostic ... -
Synthesis and In vitro Evaluation of Thiadiazole Derivatives as AChE, BuChE and LOX Inhibitors
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Abu Mohsen, Usama; Temel, Halide Edip; Çiftçi, Gülsen Akalın; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2014)N'-Benzylidene-2-[[5-(phenylamino)-1,3,4-thiadiazol-2-yl]thio]acetohydrazide derivatives (5a-p) were synthesized to screen for their AChE, BuChE and LOX inhibitory activity. The CCK-8 assay was also carried out to determine ... -
Synthesis of novel 3, 5, 6-trisubstituted triazine derivatives and their biological activity evaluation as potential antitumor and anti-inflammatory agents
Yurttaş, Leyla; Şahin, Z.; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Demirayak, Şeref (University of Istanbul, 2016)In this study, new 3, 5, 6-trisubstituted 1, 2, 4-triazine derivatives (1-9) were synthesized and their structures were determined by using NMR, IR and Mass spectroscopic methods. In vitro antitumor activities against MCF-7 ...