Kurum Yazarı "Tunalı, Yağmur" Farmasötik Kimya Anabilim Dalı İçin Listeleme
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Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety
Özkay, Yusuf; Tunalı, Yağmur; Karaca, Hülya; Işıkdağ, İlhan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In this study 12 novel benzimidazole compounds bearing hydrazone moiety were synthesized in order to investigate their possible antibacterial and antifungal activity. Structures of the synthesized compounds were elucidated ... -
Antimicrobial Activity of a New Combination System of Benzimidazole and Various Azoles
Özkay, Yusuf; Tunalı, Yağmur; Karaca, Hülya; Işıkdağ, İlhan (Wiley-Blackwell, 2011)In the present study a new series of benzimidazole derivatives bearing various (benz)azolylthio moieties were synthesized so as to investigate their antimicrobial activity. Structures of the target compounds (5a-5i) were ... -
Antimicrobial Activity of a New Series of Benzimidazole Derivatives
Özkay, Yusuf; Tunalı, Yağmur; Karaca, Hülya; Işıkdağ, İlhan (Pharmaceutical Soc Korea, 2011)Due to antimicrobial importance of benzimidazoles and hydrazones, some benzimidazole-hydrazone compounds were synthesized to screen their antimicrobial activity. Structures of the synthesized compounds were elucidated by ... -
Antimicrobial and anticancer effects of some 2-(substitutedsulfanyl)-N-(5-methyl-isoxazol-3-yl)acetamide derivatives
Özkay, Yusuf; Seller, Zerrin; Önder, Nur İpek; Tunalı, Yağmur; Karaca Gencer, Hülya; Işıkdağ, İlhan; Uçucu, Ümit (Springer Birkhauser, 2013)In the present study, some isoxazole-(benz)azole derivatives (3a-3j) were synthesized by considering antimicrobial and anticancer potencies of azole compounds. Chemical structures of obtained compounds (3a-3j) were confirmed ... -
Antimicrobial Effect of Some New 2,5-Disubstituted Benzimidazoles
Özkay, Yusuf; Tunalı, Yağmur; Karaca, H.; Işıkdağ, İlhan (Elsevier Science BV, 2011)… -
Cytotoxic and genotoxic effects of [Ru(phi)(3)](2+) evaluated by Ames/Salmonella and MTT methods
Benkli, Kadriye; Tunalı, Yağmur; Cantürk, Zerrin; Artagan, öge; Alanyali, Filiz (Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)In this work, we synthesized and evaluated the cytotoxic effect of [Ru(phi)(3)](2+), on rat C6 glioma cell line. Cell viability was determined by assay with 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide ... -
Some 3-alkyl-6-(2-aryl-2-oxo-1-ethyl)-7-oxothiazolo [4,5-d]pyrimidin-2(3H)-thione derivatives and their antimicrobial activities
In this study, some 3-alkyl-6-(2-aryl-2-oxo-1-ethyl)-7-oxothiazolo [4,5-d]pyrimidin-2(3H)-thione derivatives have been synthesized by reacting 3-alkyl-7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thiones with various ?-bromoacetophenones. ... -
Some 6-substituted 3-aryl-7-oxothiazolo[4,5-d]pyrimidin-2(3H)-thione derivatives and their antimicrobial activities
Demirayak, Şeref; Ali, Faten Dali; Osman, Baland Sirvan; Tunalı, Yağmur (Taylor & Francis LTD, 2007)In this study, 3-aryl-6-substituted thiazolopyrimidin-2(3H)-thione derivatives 4 and 6 have been synthesized by reacting thiazolopyrimidines 2 with omega-bromoacetophenone 3 and 2-chloro-N-(2-thiazolyl)acetamides 5. The ... -
Synthesis and antifungal activities of some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl) benzofuran-2-yl] ketoximes
Gündoğdu-Karaburun, Nalan; Benkli, Kadriye; Tunalı, Yağmur; Uçucu, Ümit; Demirayak, Şeref (Elsevier France-Editions Scientifiques Medicales Elsevier, 2006)In this study, some aryl [3-(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketones, aryl (3-methyl-benzofuran-2-yl) ketoximes and aryl [3(imidazol-1-yl/triazol-1-ylmethyl)benzofuran-2-yl] ketoximes were synthesised ... -
Synthesis and antimicrobial activities of some 1-[(N,N-disubstitutedthiocarbamoylthio)acetyl]-3,5-diaryl-2-pyrazolines
Turan, Gülhan; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Chevallet, Pierre; Tunalı, Yağmur (Taylor & Francis LTD, 2005)The increasing clinical importance of drug-resistant fungal and bacterial pathogens has lent additional urgency to microbiological research and new antimicrobial compound development. For this put-pose, new pyrazoline ... -
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives
Yurttaş, Leyla; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Tunalı, Yağmur; Karaca Gencer, Hülya (Taylor & Francis LTD, 2013)In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and ... -
Synthesis and Antimicrobial Activity of Some Novel Benzimidazole Hydrazides
Özkay, Yusuf; Tunalı, Yağmur; Karaca, H.; Işıkdağ, İlhan (Asian Journal Of Chemistry, 2011)The present study was undertaken to synthesize some 4-(5,6-dichloro-1H-benzimidazole-2-yl)phenoxyacetic acid-4-substituted benzylidene hydrazide derivatives and investigate their possible antimicrobial activity. Chemical ... -
Synthesis and Antimicrobial Evaluation of Some 2,5-Disubstituted Benzimidazole Derivatives
Yurttaş, Leyla; Özkay, Yusuf; Karaca, Hülya; Tunalı, Yağmur; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2013)Some benzimidazole derivatives bearing hydrazone moiety were synthesized and their in vitro antimicrobial activity was determined against various gram-positive and gram-negative bacteria, and fungi using microbroth dilution ... -
Synthesis and biological activities of new hydrazide derivatives
Özdemir, Ahmet; Turan, Gülhan; Kaplancıklı, Zafer Asım; Tunalı, Yağmur (Taylor & Francis LTD, 2009)The synthesis of a new series of imidazo[1,2-a]pyrazine-2-carboxylic acid arylidene-hydrazides is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR, FAB(+)-MS spectral data. Their biological ... -
Synthesis and Biological Evaluation of Pyrazoline Derivatives Bearing an Indole Moiety as New Antimicrobial Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Karaca Gencer, Hülya; Tunalı, Yağmur (Wiley-V C H Verlag GMBH, 2013)1-(p-Methylphenyl)-3,5-diaryl-2-pyrazoline derivatives (2a-f) were synthesized via the treatment of 1-(1H-indol-3-yl)-3-aryl-2-propen-1-ones (1a-f) with p-methylphenylhydrazine hydrochloride in hot acetic acid. The structures ... -
Synthesis and initial biological evaluation of substituted 1-phenylamino-2-thio-4,5-dimethyl-1H-imidazole derivatives
Yurttaş, Leyla; Duran, Murat; Demirayak, Şeref; Karaca Gencer, Hülya; Tunalı, Yağmur (Pergamon-Elsevier Science LTD, 2013)In this work, some new 2-[(4,5-dimethyl-1-(arylamino)-1H-imidazol-2-yl)thio]-1-(aryl) ethanone derivatives were synthesized and investigated for their antibacterial, antifungal and anticancer activities. Toxicity of the ... -
Synthesis of some 2-[(benzazole-2-yl)thioidiphenylmethylacetamide derivatives and their antimicrobial activity
Turan, Gülhan; Kaplancıklı, Zafer Asım; Uçucu, U; Özdemir, Ahmet; Chevallet, P; Tunalı, Yağmur (Taylor & Francis LTD, 2004)Some 2-[(benzazole-2-yl)thio]diphenylmethylacetamide derivatives were synthesized by reacting 2-chloroacethylaminodiphenylmethane with benzazole-2-thions. The structure elucidation of the compounds was performed by IR, 1H ... -
Synthesis of Some 4-Phenyl/Cyclohexyl-5-(L-Phenoxyethyl)-3-[(3,5-Diaryl-2-Pyrazolinyl)Acetyl]Thio-4h-L,2,4-Triazole Derivatives and their Antifungal Activity
Turan, Gülhan; Kaplancıklı, Zafer Asım; Özdemır, Ahmet; Demirayak, Şeref; Uçucu, Ümit; Merıç, Asiye; Tunalı, Yağmur (2011)Triazol türevleri, azol antifungallerin en büyük kimyasal grubudur. Günümüzde flukonazol ve itrakonazol en sık kullanılan triazol türevleridir. Diğer antifungaller ile kıyaslandığında, düşük toksisite ve geniş etki spektrumuna ... -
Synthesis of Some Thienyl-Triazine Derivatives and Antimicrobial Activity
Kaplancıklı, Zafer Asım; Turan-Zirouni, G.; Özdemir, Ahmet; Altıntop, Mehlika Dilek; Tunalı, Yağmur (Asian Journal Of Chemistry, 2010)Some 4-(1-aryl-ethylideneamino)-5-phenyl-1,4-dihydro-2H-[2,4]triazine-3-thione derivatives were synthesized and evaluated for their antimicrobial activity. The reaction of 2-acetylfuran or 2-acetyl-thiophene with ...