Kurum Yazarı "Yurttaş, Leyla" Makale Koleksiyonu İçin Listeleme
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A preliminary investigation of anticancer activity of novel benzothiazole derivatives against A549 lung carcinoma cell line
Yurttaş, Leyla; Kaya Çavuşoğlu, Betül; Sever, Arda; Çiftçi, Gülsen Akalın (Walter De Gruyter GMBH, 2017)Objective(s): In this study, it was aimed to synthesize new chemotherapeutic agents based on known antiproliferative properties of benzothiazol-2-amine moiety. The antitumor activity of the newly synthesized compounds was ... -
Pyridine-substituted thiazolylphenol derivatives: Synthesis, modeling studies, aromatase inhibition, and antiproliferative activity evaluation
Ertaş, Merve; Şahin, Zafer; Berk, Barkın; Yurttaş, Leyla; Biltekin, Sevde N.; Demirayak, Şeref (Wiley-V C H Verlag GMBH, 2018)Drugs used in breast cancer treatments target the suppression of estrogen biosynthesis. During this suppression, the main goal is to inhibit the aromatase enzyme that is responsible for the cyclization and structuring of ... -
Some Thiazole Derivatives Combined with Different Heterocycles: Cytotoxicity Evaluation and Apoptosis Inducing Studies
Yurttaş, Leyla; Demir, Bahar; Çiftçi, Gülsen Akalın (Bentham Science Publ LTD, 2018)Background: Thiazole ring is an outstanding structure found in many biologically active compounds and clinically available drugs. Because of synthesis simplicity of its derivatives and having a wide range of biological ... -
Studies on non-steroidal inhibitors of aromatase enzyme; 4-(aryl/heteroaryl)-2-(pyrimidin-2-yl)thiazole derivatives
Şahin, Zafer; Ertaş, Merve; Berk, Barkın; Biltekin, Sevde Nur; Yurttaş, Leyla; Demirayak, Şeref (Pergamon-Elsevier Science LTD, 2018)Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on developing non-steroidal derivatives for their ... -
Synthesis and anti-cancer activity evaluation of new aurone derivatives
Demirayak, Şeref; Yurttaş, Leyla; Gündoğdu-Karaburun, Nalan; Karaburun, Ahmet Çağrı; Kayagil, İsmail (Taylor & Francis LTD, 2015)In this study, we have synthesized 2-[3-or 4-(2-aryl-2-oxoethoxy) arylidene] benzofuran-3-one derivatives (D1-D38) and evaluated their anti-cancer activities. The final compounds were obtained in multistep synthesis reactions ... -
Synthesis and anti-nociceptive, anti-inflammatory activities of new aroyl propionic acid derivatives including N-acylhydrazone motif
Turan, Gülhan; Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Can, Özgür Devrim; Özkay, Ümide Demir (Springer Birkhauser, 2015)In the present study, new 4-[4-[2-(2-(4-substituted benzylidene)hydrazinyl)-2-oxoethoxy]phenyl]-4-oxobutanoic acid derivatives were synthesized, and their anti-nociceptive and anti-inflammatory activities were investigated. ... -
Synthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives containing (benz)azole moiety
Yurttaş, Leyla; Özkay, Yusuf; Akalın-Çiftçi, Gülsen; Ulusoylar-Yıldırım, Şafak (Informa Healthcare, 2014)A new class of novel thiazole-(benz) azole derivatives was synthesized to investigate their anticancer activity. The structure of the compounds was confirmed by IR, H-1-NMR, and MS spectral data and elemental analyses. ... -
Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives
Demirayak, Şeref; Yurttaş, Leyla (Taylor & Francis LTD, 2014)The synthesis of some new pyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities were aimed in this work. Thus, 2-acetylbenzimidazole was reacted with appropriate alpha-bromoacetophenones ... -
Synthesis and Anticancer Activity of Some 1H-inden-1-one Substituted (Heteroaryl)Acetamide Derivatives
Karaburun, Ahmet Çağrı; Gündoğdu-Karaburun, Nalan; Yurttaş, Leyla; Kayagil, İsmail; Demirayak, Şeref (Bentham Science Publ LTD, 2019)Background: The synthesis of 2-[3/4-((6-substituted-1-oxo-2,3-dihydro-1H-inden-2ylidene) methyl)phenoxy]-N-(heteroaryl)acetamide derivatives and the investigation of their anticancer activity were studied. Methods: ... -
Synthesis and Anticancer Activity of Some 2-[3/4-(2-Substituted Phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one Derivatives
Gündoğdu-Karaburun, Nalan; Karaburun, Ahmet Çağrı; Demirayak, Şeref; Kayagil, İsmail; Yurttaş, Leyla (Bentham Science Publ LTD, 2014)The synthesis of 2-[3/ 4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1one derivatives and the investigation of their anticancer activity were studied. 2-(3- or 4-Hydroxybenzylidene) ... -
Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Göğer, Gamze; Demirci, Fatih (Taylor & Francis LTD, 2016)In this study, we have performed the synthesis of new N-(arylidene)-4-[(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a-s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target ... -
Synthesis and Antifungal Activity Evaluation of New 1,2,4-Triazole Derivatives Bearing Salicylidene Hydrazide Moiety
Demirayak, Şeref; Kayagil, İsmail; Yurttaş, Leyla; Er, Sevda (Bentham Science Publ LTD, 2016)A series of new N'-(arylidene)-2-[(1-(4-nitrophenyl)-1H-1,2,4-triazol-3-yl)oxy]acetohydrazide derivatives (116) were prepared and tested for theira ntifungal activity against six plant pathogens, three human pathogens and ... -
Synthesis and antimicrobial activity evaluation of new dithiocarbamate derivatives bearing thiazole/benzothiazole rings
Yurttaş, Leyla; Özkay, Yusuf; Duran, Murat; Turan, Gülhan; Özdemir, Ahmet; Cantürk, Zerrin; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)The synthesis of 2-(substituted phenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A1-A24) derivatives and 2-(4-substituted thiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B1-B14) ... -
Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles
Yurttaş, Leyla; Şahin, Z.; Er, S.; Demirayak, Şeref (University of Istanbul, 2016)In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial ... -
Synthesis and Antimicrobial Activity of New Pyrimidine-Hydrazones
Kaplancıklı, Zafer Asım; Yurttaş, Leyla; Turan, Gülhan; Özdemir, Ahmet; Göğer, Gamze; Demirci, Fatih; Abu Mohsen, Usama (Bentham Science Publ LTD, 2014)The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide ... -
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives
Yurttaş, Leyla; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Tunalı, Yağmur; Karaca Gencer, Hülya (Taylor & Francis LTD, 2013)In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and ... -
Synthesis and Antimicrobial Activity of Some New N-(1H-benzimidazol-2yl)-2-mercaptoacetamide Derivatives
Evren, Asaf Evrim; Tekinkoca, Sinem; Yurttaş, Leyla (Bentham Science Publ LTD, 2018)Background: Due to multi-drug, extended-drug, and pandrug resistance phenotypes, bacterial resistance to antibiotics and fungal infections are a general health issue. Particulary, increase of fungal infections due to ... -
Synthesis and Antimicrobial Evaluation of Some 2,5-Disubstituted Benzimidazole Derivatives
Yurttaş, Leyla; Özkay, Yusuf; Karaca, Hülya; Tunalı, Yağmur; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2013)Some benzimidazole derivatives bearing hydrazone moiety were synthesized and their in vitro antimicrobial activity was determined against various gram-positive and gram-negative bacteria, and fungi using microbroth dilution ... -
Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4-aryl-2-thiazolyl])hydrazone]-1H-indol-2,3-diones
Yurttaş, Leyla; Ertaş, Merve; Cankılıç, Meral Yılmaz; Demirayak, Şeref (University of Istanbul, 2017)A series of 3-[(4-aryl-2-thiazolyl)hydrazone]-1H-indol-2,3-dione derivatives (2a-f) were designed and synthesized using isatin as starting material. The obtained thiazole compounds were screened to investigate their ... -
Synthesis and antiproliferative activity evaluation of new thiazole-benzimidazole derivatives using real-time cell analysis (RTCA DP)
Özkay, Yusuf; Yurttaş, Leyla; Dikmen, Miriş; EnGür, Selin (Springer Birkhauser, 2016)A series of new 2-[(5-substituted-1H-benzimidazol-2-yl)thio]-N-[4-[2-phenylthiazol-4-yl]phenyl]acetamide derivatives (4a-p) were synthesized according to the reported literature, and anticancer activity of the compounds ...