Yayıncı "Bentham Science Publ LTD" Makale Koleksiyonu için listeleme
Toplam kayıt 45, listelenen: 21-40
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Synthesis and Antiproliferative Activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) Benzofuran-3-one Derivatives
(Bentham Science Publ LTD, 2016)The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according ... -
Synthesis and Biological Activity of Thiazole Dithiocarbamate Derivatives
(Bentham Science Publ LTD, 2014)In this study, we aimed at the synthesis of new 2-((5-substituted-4-methylthiazol-2-yl) amino)-2-oxoethyl 4-substitutedpiperazine- 1-carbodithioate derivatives and their antibacterial, antifungal, antioxidant and AChE ... -
Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors
(Bentham Science Publ LTD, 2018)Background: 1,3,4-Oxadiazoles have been known with a wide variety of pharmacological activities including anticancer activity. Objective: In this study, novel 2,5-disubstituted 1,3,4-oxadiazole derivatives were synthesized ... -
Synthesis and Biological Evaluation of New Pyrazole-based Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents
(Bentham Science Publ LTD, 2014)New pyrazole-based thiazolyl hydrazone derivatives were obtained via the ring closure reaction of 3,5-dimethyl-1H-1-phenylpyrazole-4-carboxaldehyde thiosemicarbazone with 2-bromoacetophenone derivatives. The compounds were ... -
Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents
(Bentham Science Publ LTD, 2018)Background: In medicinal chemistry, thiazoles have gained great importance in anti-fungal and anticancer drug design and development. Objectives: The aim of this study was to synthesize new quinoline-based thiazolyl hydrazone ... -
Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents
(Bentham Science Publ LTD, 2013)In this study, N-(benzothiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives (1-24) were obtained by the reaction of 2-chloro-N-(benzothiazole-2-yl)acetamides with piperidine derivatives. The structures of the compounds ... -
Synthesis and Biological Evaluation of Some Hydrazone Derivatives as Anti-inflammatory Agents
(Bentham Science Publ LTD, 2012)In the present study, some hydrazone derivatives were synthesized via the reaction of 3-cyclohexylpropionic acid hydrazide with various benzaldehydes. The chemical structures of the compounds were elucidated by spectroscopic ... -
Synthesis and Evaluation of a New Series of Arylidene Indanones as Potential Anticancer Agents
(Bentham Science Publ LTD, 2018)Background: Arylidene indanones have attracted a great deal of interest due to their outstanding therapeutic applications. In particular, considerable research has pointed out the importance of arylidene indanones in the ... -
Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors
(Bentham Science Publ LTD, 2017)Background: In recent years, the relationship between overexpression of matrix metalloproteinases ( MMPs) and tumor invasion/metastasis has prompted researchers to develop MMP inhibitors as anticancer drugs. Objective: The ... -
Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents
(Bentham Science Publ LTD, 2018)Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and ... -
Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents
(Bentham Science Publ LTD, 2014)In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazo ... -
Synthesis and Evaluation of Heterocycles Based Chalcone Derivatives as Anti-proliferative Agents
(Bentham Science Publ LTD, 2018)Background: The lack of selectivity and development of drug-resistance encourage researchers to search for novel, more efficient and multi-targeted agents with less toxicity. Objective: In this paper, a series of novel ... -
Synthesis and Evaluation of New Thiazole Derivatives as Potential Antimicrobial Agents
(Bentham Science Publ LTD, 2016)In an effort to develop potent antimicrobial agents, new thiazolyl hydrazone derivatives were synthesized and investigated for their inhibitory effects on pathogenic bacteria and yeasts. MTT assay was carried out to determine ... -
Synthesis and Evaluation of New Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents
(Bentham Science Publ LTD, 2017)Background: In recent years, thiazole derivatives incorporated with hydrazone moiety have attracted a great deal of interest due to their pivotal role in the field of current cancer research. Methods: In the present study, ... -
Synthesis and Evaluation of Tetrazole-Based Hydrazone Derivatives Bearing a Pyridine Moiety as Antimicrobial Agents
(Bentham Science Publ LTD, 2015)2-[(1-Methyl/Phenyl-1H-tetrazol-5-yl)thio]-N'-[(aryl) methylidene/ethylidene] acetohydrazides were synthesized and investigated in vitro against pathogenic bacteria and Candida species for their antimicrobial activity using ... -
Synthesis and In Vitro Evaluation of Furan-Based Chalcone Derivatives as Antimicrobial Agents
(Bentham Science Publ LTD, 2015)Some furan-based chalcone derivatives were synthesized via the Claisen-Schmidt condensation of 5-arylfurfural derivatives with 4'-cyanoacetophenone. The synthesized derivatives were investigated for their antimicrobial ... -
Synthesis and In Vitro Evaluation of Some Hydrazone Derivatives as Potential Antibacterial Agents
(Bentham Science Publ LTD, 2014)Nineteen N'-(benzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazides were obtained via the nucleophilic addition-elimination reaction of 2-[(pyrimidin-2-yl)thio)]acetohydrazide with aromatic aldehydes. The synthesized compounds ... -
Synthesis and In vitro Evaluation of Thiadiazole Derivatives as AChE, BuChE and LOX Inhibitors
(Bentham Science Publ LTD, 2014)N'-Benzylidene-2-[[5-(phenylamino)-1,3,4-thiadiazol-2-yl]thio]acetohydrazide derivatives (5a-p) were synthesized to screen for their AChE, BuChE and LOX inhibitory activity. The CCK-8 assay was also carried out to determine ... -
Synthesis and Mosquitocidal Activity of a Series of Hydrazone Derivatives against Aedes aegypti
(Bentham Science Publ LTD, 2018)Background: Aedes aegypti is an important mosquito vector for the transmission of several infectious diseases. Current insecticides play a vital role in controlling mosquitoes; however, the frequent use of insecticides has ... -
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
(Bentham Science Publ LTD, 2017)In the present study, nineteen new fluoro-benzimidazole derivatives, including nifuroxazide analogs, were synthesized by microwave-supported reactions and tested against a panel of pathogenic microorganisms consisting of ...