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Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Göğer, Gamze; Demirci, Fatih (Taylor & Francis LTD, 2016)In this study, we have performed the synthesis of new N-(arylidene)-4-[(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a-s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target ... -
Synthesis and Antimicrobial Activity of New Pyrimidine-Hydrazones
Kaplancıklı, Zafer Asım; Yurttaş, Leyla; Turan, Gülhan; Özdemir, Ahmet; Göğer, Gamze; Demirci, Fatih; Abu Mohsen, Usama (Bentham Science Publ LTD, 2014)The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide ... -
Synthesis and Evaluation of Thiazole - Pyrimidine Derivatives as New Anticandidal and Cytotoxic Agents
Turan, Gülhan; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Demirci, Fatih; Ilgın, Sinem; Göğer, Gamze (Springer, 2014)The aim of this study was to describe the synthesis of four new 2-(3,4-diphenyl-3H-thiazol-2-ylidene)amino-4,6-dimethylpyrimidine derivatives, which were screened for their anticandidal activity and cytotoxicity. The title ... -
Synthesis and In Vitro Evaluation of Some Hydrazone Derivatives as Potential Antibacterial Agents
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Göğer, Gamze; Demirci, Fatih (Bentham Science Publ LTD, 2014)Nineteen N'-(benzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazides were obtained via the nucleophilic addition-elimination reaction of 2-[(pyrimidin-2-yl)thio)]acetohydrazide with aromatic aldehydes. The synthesized compounds ... -
Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains
Yurttaş, Leyla; Özkay, Yusuf; Demirci, Fatih; Göğer, Gamze; Yıldırım, Şafak Ulusoylar; Abu Mohsen, Usama; Kaplancıklı, Zafer Asım (Scientific Technical Research Council Turkey-Tubitak, 2014)Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a-j) were confirmed by ...