Kurum Yazarı "Atlı Eklioğlu, Özlem" Makale Koleksiyonu İçin Listeleme
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In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells
Yurttaş, Leyla; Demirayak, Şeref; Ilgın, Sinem; Atlı Eklioğlu, Özlem (Pergamon-Elsevier Science LTD, 2014)A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis(4-subtituted phenyl)-1,2,4-triazin-3-yl) piperazin- ... -
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve (MDPI AG, 2017)In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with ... -
A novel series of thiazolyl-pyrazoline derivatives: Synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirel, Rasime; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the current work, new thiazolyl pyrazoline derivatives (1-22) were synthesized and evaluated for their antifungal effects against pathogenic yeasts and molds using a broth microdilution assay. Ames assay was carried out ... -
Synthesis and anticancer activity of some novel benzothiazole-thiazolidine derivatives
Osmaniye, Derya; Levent, Serkan; Ardıç, Cankiz Mina; Atlı Eklioğlu, Özlem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2018)Sixteen new 2-(benzothiazol-2-ylthio)-N-(3-substituted-4-(3,4-substitutedphenyl)thiazol-2(3H)-ylidene)acetohydrazide derivatives (4a-4p) were synthesized. The structures of the synthesized compounds were elucidated using ... -
Synthesis and Anticandidal Activity of New Imidazole-Chalcones
Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI, 2018)In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl) prop-2-en-1-one derivatives (3a-3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole ... -
Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents
Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Ilgın, Sinem; Demirel, Rasime; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New thiosemicarbazone derivatives (1-10) were obtained via the reaction of 4-(naphthalen-1-yl)thiosemicarbazide with fluoro-substituted aromatic aldehydes. The synthesized compounds were evaluated for their in vitro ... -
Synthesis and Biological Evaluation of New Pyrazole-based Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Ilgın, Sinem; Atlı Eklioğlu, Özlem (Bentham Science Publ LTD, 2014)New pyrazole-based thiazolyl hydrazone derivatives were obtained via the ring closure reaction of 3,5-dimethyl-1H-1-phenylpyrazole-4-carboxaldehyde thiosemicarbazone with 2-bromoacetophenone derivatives. The compounds were ... -
Synthesis and Biological Evaluation of New Quinoline-Based Thiazolyl Hydrazone Derivatives as Potent Antifungal and Anticancer Agents
Erguc, Ali; Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Sever, Belgin; İşcan, Gökalp; Gormus, Gözde; Özdemir, Ahmet (Bentham Science Publ LTD, 2018)Background: In medicinal chemistry, thiazoles have gained great importance in anti-fungal and anticancer drug design and development. Objectives: The aim of this study was to synthesize new quinoline-based thiazolyl hydrazone ... -
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; İşcan, Gökalp; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)New hydrazone derivatives were synthesized via the nucleophilic addition-elimination reaction of 2-[(1-methyl-1H-tetrazol-5-yl]thio)]acetohydrazide with aromatic aldehydes/ketones. The compounds were tested in vitro against ... -
Synthesis and Evaluation of A New Series of Thiazole Derivatives as Potential Antitumor Agents and MMP Inhibitors
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Sever, Belgin; Baysal, Merve; Temel, Halide Edip; Özdemir, Ahmet (Bentham Science Publ LTD, 2017)Background: In recent years, the relationship between overexpression of matrix metalloproteinases ( MMPs) and tumor invasion/metastasis has prompted researchers to develop MMP inhibitors as anticancer drugs. Objective: The ... -
Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Turan, Gülhan; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and ... -
Synthesis and Evaluation of Heterocycles Based Chalcone Derivatives as Anti-proliferative Agents
Kaya Çavuşoğlu, Betül; Atlı Eklioğlu, Özlem; Gormus, Geozde; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background: The lack of selectivity and development of drug-resistance encourage researchers to search for novel, more efficient and multi-targeted agents with less toxicity. Objective: In this paper, a series of novel ... -
Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Ardıç, Cankiz Mina; Özkay, Yusuf; Atlı Eklioğlu, Özlem (Walter De Gruyter GMBH, 2018)Objectives: Cancer is one of the leading causes of death throughout the world. Current therapy options suffer from the major limitations of side effects and drug resistance. Thus, continuing search for newer and safer ... -
Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9
Özdemir, Ahmet; Sever, Belgin; Altıntop, Mehlika Dilek; Temel, Halide Edip; Atlı Eklioğlu, Özlem; Baysal, Merve; Demirci, Fatih (MDPI, 2017)Matrix metalloproteinases (MMPs) are important proteases involved in tumor progression including angiogenesis, tissue invasion, and migration. Therefore, MMPs have been reported as potential diagnostic and prognostic ... -
Synthesis and Evaluation of New Thiazole Derivatives as Potential Antimicrobial Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Atlı Eklioğlu, Özlem; Cantürk, Zerrin; Baysal, Merve; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2016)In an effort to develop potent antimicrobial agents, new thiazolyl hydrazone derivatives were synthesized and investigated for their inhibitory effects on pathogenic bacteria and yeasts. MTT assay was carried out to determine ... -
Synthesis and Evaluation of New Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents
Kaplancıklı, Zafer Asım; Sever, Belgin; Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Baysal, Merve; Özdemir, Ahmet (Bentham Science Publ LTD, 2017)Background: In recent years, thiazole derivatives incorporated with hydrazone moiety have attracted a great deal of interest due to their pivotal role in the field of current cancer research. Methods: In the present study, ... -
Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirci, Fatih; Kaplancıklı, Zafer Asım (MDPI AG, 2014)Fourteen new thiazolyl hydrazone derivatives were synthesized and evaluated for their anticandidal activity using a broth microdilution assay. Among the synthesized compounds, 2-[2-((5-(4-chloro-2-nitrophenyl) furan-2-yl) ... -
Synthesis of New Thiazolyl-pyrazoline Derivatives and Evaluation of Their Antimicrobial, Cytotoxic and Genotoxic Effects
Sever, Belgin; Altıntop, Mehlika Dilek; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve; Özdemir, Ahmet (Bentham Science Publ LTD, 2018)Background: Pyrazolines have played a pivotal role in antimicrobial and anticancer drug discovery. Moreover, thiazoles have attracted a great deal of interest due to their crucial roles in the lead identification and ... -
Synthesis of novel thiazolylpyrazoline derivatives and evaluation of their antimicrobial activities and cytotoxicities
Tabbi, Aouatef; Kaplancıklı, Zafer Asım; Tebbani, Dahmane; Yurttaş, Leyla; Cantürk, Zerrin; Atlı Eklioğlu, Özlem; Turan, Gülhan (Scientific Technical Research Council Turkey-Tubitak, 2016)Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were confirmed by IR, H-1 ... -
Synthesis of novel thiazolylpyrazoline derivatives and evaluation of theirantimicrobial activities and cytotoxicities
Tabbı, Aouatef; Kaplancıklı, Zafer Asım; Tebbanı, Dahmane; Yurttaş, Leyla; Cantürk, Zerrin; Atlı Eklioğlu, Özlem; Turan, Gülhan (2016)Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarba-moyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were con rmed by IR,1HNMR,13C ...