Kurum Yazarı "Cantürk, Zerrin" Makale Koleksiyonu İçin Listeleme
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Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives
Turan, Gülhan; Yurttaş, Leyla; Saka, Güner; Cantürk, Zerrin; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Natural Products Inc, 2016)The synthesis of nine new quinazoline derivatives (2a-21) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine ... -
Cytotoxic and genotoxic effects of [Ru(phi)(3)](2+) evaluated by Ames/Salmonella and MTT methods
Benkli, Kadriye; Tunalı, Yağmur; Cantürk, Zerrin; Artagan, öge; Alanyali, Filiz (Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)In this work, we synthesized and evaluated the cytotoxic effect of [Ru(phi)(3)](2+), on rat C6 glioma cell line. Cell viability was determined by assay with 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide ... -
New Procaspase Activating Compound (PAC-1) Like Molecules as Potent Antitumoral Agents Against Lung Cancer
Yurttaş, Leyla; Öztürk, Ömer; Cantürk, Zerrin (Bentham Science Publ LTD, 2019)Background: In this study, novel ortho-hydroxy N-acyl hydrazone moiety including compounds (3a-l) were designed, based on procaspase activating compound (PAC-1) which is a small molecule known with antitumor activity. The ... -
Synthesis and antimicrobial activity evaluation of new dithiocarbamate derivatives bearing thiazole/benzothiazole rings
Yurttaş, Leyla; Özkay, Yusuf; Duran, Murat; Turan, Gülhan; Özdemir, Ahmet; Cantürk, Zerrin; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2016)The synthesis of 2-(substituted phenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A1-A24) derivatives and 2-(4-substituted thiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B1-B14) ... -
Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents
Abu Mohsen, Usama; Yurttaş, Leyla; Acar, U.; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Karaca Gencer, Hülya; Cantürk, Zerrin (Georg Thieme Verlag Kg, 2015)In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]- ... -
Synthesis and Evaluation of Bis-pyrazoline Derivatives as Potential Antimicrobial Agents
Altıntop, Mehlika Dilek; Abu Mohsen, Usama; Karaca, Hülya; Cantürk, Zerrin; Özdemir, Ahmet (Bentham Science Publ LTD, 2014)In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazo ... -
Synthesis and Evaluation of New Thiazole Derivatives as Potential Antimicrobial Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Atlı Eklioğlu, Özlem; Cantürk, Zerrin; Baysal, Merve; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2016)In an effort to develop potent antimicrobial agents, new thiazolyl hydrazone derivatives were synthesized and investigated for their inhibitory effects on pathogenic bacteria and yeasts. MTT assay was carried out to determine ... -
Synthesis and Evaluation of Tetrazole-Based Hydrazone Derivatives Bearing a Pyridine Moiety as Antimicrobial Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Cantürk, Zerrin; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2015)2-[(1-Methyl/Phenyl-1H-tetrazol-5-yl)thio]-N'-[(aryl) methylidene/ethylidene] acetohydrazides were synthesized and investigated in vitro against pathogenic bacteria and Candida species for their antimicrobial activity using ... -
Synthesis and In Vitro Evaluation of Furan-Based Chalcone Derivatives as Antimicrobial Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Cantürk, Zerrin; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2015)Some furan-based chalcone derivatives were synthesized via the Claisen-Schmidt condensation of 5-arylfurfural derivatives with 4'-cyanoacetophenone. The synthesized derivatives were investigated for their antimicrobial ... -
Synthesis and In Vitro Evaluation of New Thiosemicarbazone Derivatives as Potential Antimicrobial Agents
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Sever, Belgin; Cantürk, Zerrin; Özdemir, Ahmet (Hindawi LTD, 2016)In an effort to develop potent antimicrobial agents, new thiosemicarbazone derivatives were synthesized via the reaction of 4-[4-(trifluoromethyl)phenyl]thiosemicarbazide with aromatic aldehydes. The compounds were evaluated ... -
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Cantürk, Zerrin; Bueno, Juan; Demirci, Fatih; Koparal, Ali Savaş (Bentham Science Publ LTD, 2017)In the present study, nineteen new fluoro-benzimidazole derivatives, including nifuroxazide analogs, were synthesized by microwave-supported reactions and tested against a panel of pathogenic microorganisms consisting of ... -
Synthesis of novel thiazolylpyrazoline derivatives and evaluation of their antimicrobial activities and cytotoxicities
Tabbi, Aouatef; Kaplancıklı, Zafer Asım; Tebbani, Dahmane; Yurttaş, Leyla; Cantürk, Zerrin; Atlı Eklioğlu, Özlem; Turan, Gülhan (Scientific Technical Research Council Turkey-Tubitak, 2016)Several novel thiazolylpyrazoline derivatives were synthesized by reacting substituted 3,5-diaryl-1-thiocarbamoyl-2-pyrazolines with phenacylbromides. The structures of the synthesized compounds were confirmed by IR, H-1 ... -
The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species
Kaya Çavuşoğlu, Betül; Yurttaş, Leyla; Cantürk, Zerrin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In search of potent and safe antifungal agents, herein, we report the synthesis, characterization and biological activities of triazole-oxadiazole compounds. The structural verification of the molecules was carried out by ... -
Synthesis, Antituberculotic, and Cytotoxic Properties of New Hydrazone Derivatives Bearing Pyrimidine-Alkylsulfanyl Moiety
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Cantürk, Zerrin; Karaca Gencer, Hülya (Taylor & Francis LTD, 2015)A series of N'-(arylidene)-4-[(pyrimidine-2-yl)thio]butanohydrazide derivatives (3a-3m) has been synthesized and investigated for their antituberculotic and cytotoxic activity. The antitubercular activities of the newly ...