Kurum Yazarı "Ilgın, Sinem" Makale Koleksiyonu İçin Listeleme
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Antiproliferative, Cytotoxic, and Apoptotic Effects of New Benzimidazole Derivatives Bearing Hydrazone Moiety
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Korkut, Büşra; Özkay, Yusuf; Ilgın, Sinem (Wiley, 2018)In order to take the advantages of the anticancer properties of benzimidazoles and hydrazones, we synthesized new 4-(5-chloro-1H-benzimidazol-2-yl)-benzoic acid benzylidene hydrazide derivatives (3a-3t) and evaluated their ... -
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
Sağlık, Begüm Nurpelin; Kaya Çavuşoğlu, Betül; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Ilgın, Sinem; Öztürk, Yusuf (Academic Press Inc Elsevier Science, 2019)New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to determine the biological effects of synthesized ... -
In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells
Yurttaş, Leyla; Demirayak, Şeref; Ilgın, Sinem; Atlı Eklioğlu, Özlem (Pergamon-Elsevier Science LTD, 2014)A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis(4-subtituted phenyl)-1,2,4-triazin-3-yl) piperazin- ... -
A novel series of thiazolyl-pyrazoline derivatives: Synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirel, Rasime; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the current work, new thiazolyl pyrazoline derivatives (1-22) were synthesized and evaluated for their antifungal effects against pathogenic yeasts and molds using a broth microdilution assay. Ames assay was carried out ... -
Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
Kaplancıklı, Zafer Asım; Levent, Serkan; Osmaniye, Derya; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Ilgın, Sinem (MDPI, 2017)Azole-based antifungal agents constitute one of the important classes of antifungal drugs. Hence, in the present work, 12 new benzimidazole-thiazole derivatives 3a-3l were synthesized to evaluate their anticandidal activity ... -
Synthesis and antimicrobial activity of new 2-((1-furan-2-yl)ethylidene)hydrazono)-4-phenylthiazol-3(2H)-amine derivatives and their schiff bases with 4-nitrobenzaldehyde
Turan, Gülhan; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Levent, Serkan; Ilgın, Sinem; Hussein, Weiam (Taylor & Francis LTD, 2018)A new series of 2-((1-furan-2-yl)ethylidene)hydrazono)-4-substitutedphenylthiazol-3(2H)-amines (2a-2o) and their Schiff bases (3a-3o) from 4-nitrobenzaldehyde were synthesized. The chemical structures of all the synthesized ... -
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease
Hussein, Weiam; Sağlık, Begüm Nurpelin; Levent, Serkan; Korkut, Büsra; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the ... -
Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents
Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Ilgın, Sinem; Demirel, Rasime; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New thiosemicarbazone derivatives (1-10) were obtained via the reaction of 4-(naphthalen-1-yl)thiosemicarbazide with fluoro-substituted aromatic aldehydes. The synthesized compounds were evaluated for their in vitro ... -
Synthesis and Biological Evaluation of New Pyrazole-based Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Ilgın, Sinem; Atlı Eklioğlu, Özlem (Bentham Science Publ LTD, 2014)New pyrazole-based thiazolyl hydrazone derivatives were obtained via the ring closure reaction of 3,5-dimethyl-1H-1-phenylpyrazole-4-carboxaldehyde thiosemicarbazone with 2-bromoacetophenone derivatives. The compounds were ... -
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; İşcan, Gökalp; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)New hydrazone derivatives were synthesized via the nucleophilic addition-elimination reaction of 2-[(1-methyl-1H-tetrazol-5-yl]thio)]acetohydrazide with aromatic aldehydes/ketones. The compounds were tested in vitro against ... -
Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Turan, Gülhan; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and ... -
Synthesis and Evaluation of Thiazole - Pyrimidine Derivatives as New Anticandidal and Cytotoxic Agents
Turan, Gülhan; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Demirci, Fatih; Ilgın, Sinem; Göğer, Gamze (Springer, 2014)The aim of this study was to describe the synthesis of four new 2-(3,4-diphenyl-3H-thiazol-2-ylidene)amino-4,6-dimethylpyrimidine derivatives, which were screened for their anticandidal activity and cytotoxicity. The title ... -
Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirci, Fatih; Kaplancıklı, Zafer Asım (MDPI AG, 2014)Fourteen new thiazolyl hydrazone derivatives were synthesized and evaluated for their anticandidal activity using a broth microdilution assay. Among the synthesized compounds, 2-[2-((5-(4-chloro-2-nitrophenyl) furan-2-yl) ... -
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
Osmaniye, Derya; Levent, Serkan; Karaduman, Abdullah Burak; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at ... -
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes
Sağlık, Begüm Nurpelin; Ilgın, Sinem; Özkay, Yusuf (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP analogues were synthesized. Structures of the synthesized ...