Kurum Yazarı "Kaplancıklı, Zafer Asım" Makale Koleksiyonu İçin Listeleme
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5-acetylindan aryloxyacetohydrazone derivatives: Synthesis and antituberculosis activity
Turan, Gülhan; Kaplancıklı, Zafer Asım (1998)Some 5-acetylindan aryloxyacetohydrazone derivatives were synthesized by reacting 5-acetylindan with aryloxyacetohidrazide derivatives in butanol. The structure of the compounds obtained were performed by using IR, 1H NMR, ... -
Antifungal Effects of Some Oxadiazole Derivatives on Pathogenic Molds
Bazı oksadiazol türevleri Aspergillus parasiticus, Aspergillus flavus, Aspergillus niger, Fusarium solani, Fusarium moniliforme and Stachybotrys chartarum 'a karşı in vitro olarak test edilmiştir. Butün bileşikler en yüksek ... -
Antifungal effects of some oxadiazole derivatives on pathogenic molds [Bazi{dotless} oksadiazol türevlerinin patojenik küfler üzerindeki antifungal etkileri]
Some oxadiazole derivatives were tested in vitro against Aspergillus parasiticus, Aspergillus flavus, Aspergillus niger, Fusarium solani, Fusarium moniliforme and Stachybotrys chartarum. All compounds showed the highest ... -
Antifungal, mosquito deterrent, and larvicidal activity of N-(benzylidene)-3-cyclohexylpropionic acid hydrazide derivatives
Tabanca, Nurhayat; Wedge, David E.; Ali, Abbas; Khan, Ikhlas A.; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek (Springer Birkhauser, 2013)Hydrazone derivatives possess good antifungal and insecticidal activities and their structures are used in pesticide design. In the present study, for the first time, ten hydrazone derivatives (1-10) were evaluated for ... -
Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives
Turan, Gülhan; Yurttaş, Leyla; Saka, Güner; Cantürk, Zerrin; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Natural Products Inc, 2016)The synthesis of nine new quinazoline derivatives (2a-21) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine ... -
Bazı İmidazo[1,2-a]pirazin Türevlerinin Sentezi ve Antinosiseptif Aktivitelerinin Değerlendirilmeleri
Amaç: İmidazopirazin halkası biyolojik olarak aktif bir heterosiklik halkadır. Bir dizi hidrazid-hidrazon türevi bileşiğin antibakteryial-antifungal, antikonvülzan, antiinflamatuvar, antitüberkülotik ve analjezik aktiviteye ... -
Carbazoles and Hydrazone-Bridged Thiazole-Pyrrole Derivatives as New Inhibitors of alpha-Glucosidase
Ghani, Usman; Albarrag, Ahmed; Yurttaş, Leyla; Demirci, Fatih; Kaplancıklı, Zafer Asım (Wiley-V C H Verlag GMBH, 2018)Carbazoles and hydrazone-bridged thiazole-pyrrole derivatives are known to exhibit a wide range of biological activities including antimicrobial activity. This work is a further extension of their biological activities ... -
Design and Synthesis of New 1,3,4-Oxadiazole - Benzothiazole and Hydrazone Derivatives as Promising Chemotherapeutic Agents
Kaya, Betül; Hussin, Weiam; Yurttaş, Leyla; Turan, Gülhan; Karaca Gencer, Hülya; Baysal, Merve; Kaplancıklı, Zafer Asım (Georg Thieme Verlag Kg, 2017)Looking for new cytotoxic and antimicrobial agents with improved antitumor activity, a series of hydrazide and oxadiazole derivatives were designed and synthesized using 3-methoxyphenol as starting substance. Novel ... -
Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Özkay, Yusuf (Informa Healthcare, 2013)In this study, some new 2-(4-substituted piperazine-1-yl)-N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives were synthesized. The synthesized compounds were screened for their anticholinesterase activity on ... -
Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
Altıntop, Mehlika Dilek; Çiftçi, Halil İbrahim; Radwan, Mohamed O.; Sever, Belgin; Kaplancıklı, Zafer Asım; Ali, Taha F. S.; Özdemir, Ahmet (MDPI, 2018)In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous ... -
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors
Altıntop, Mehlika Dilek; Sever, Belgin; Çiftçi, Gülsen Akalın; Turan, Gülhan; Kaplancıklı, Zafer Asım; Özdemir, Ahmet (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the current work, new 1,3,4-oxadiazole derivatives were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines. Compounds ... -
Design, synthesis, monoamine oxidase inhibition and docking studies of new dithiocarbamate derivatives bearing benzylamine moiety
Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Özkay, Yusuf; İnci, Beril; Kaplancıklı, Zafer Asım (Academic Press Inc Elsevier Science, 2018)A new series of thirteen 2-[(4-fluorophenyl)(4-nitrobenzyl) amino]-2-oxoethyl-1-substituted-carbodithio ate derivatives (4a-4m) were synthesized and tested for their human monoamine oxidase A and B (hMAO-A and hMAO-B) ... -
Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors
Turan, Gülhan; Hussein, Weiam; Sağlık, Begüm Nurpelin; Baysal, Merve; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language ability and other cognitive deterioration, ... -
Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies
Sever, Belgin; Altıntop, Mehlika Dilek; Kuş, Gökhan; Özkurt, Mete; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)In the current work, new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives (1-8) were synthesized via the ring closure reaction of 2-bromoacetophenone derivatives with 4-amino-5-[(5-methoxy-2-methyl-1(4-chlorobenzoyl)- ... -
N-(chroman-4-ylidene)aryloxyacetohydrazones: Synthesis and antimicrobial activity
In this study, some N-(chroman-4-ylidene)phenoxyacetohydrazone and N-(chroman-4-ylidene)phenoxypropiohydrazone compounds were synthesized. Structure of the compounds were identified by using IR, 1H NMR and MASS spectral ... -
New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Görgülü-Kahyaoğlu, Sennur (Bentham Science Publ LTD, 2017)Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis ... -
New pyrazoline derivatives and their antidepressant activity
Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Altıntop, Mehlika Dilek; Can, Özgür Devrim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental ... -
New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation
Turan, Gülhan; Yurttaş, Leyla; Tabbi, Aouatef; Çiftçi, Gülsen Akalın; Temel, Halide Edip; Kaplancıklı, Zafer Asım (MDPI AG, 2018)In this study, novel N-(3-cyclohexyl/phenyl-4-(substituted phenyl)thiazole-2(3H)-ylidene)-2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetohydrazide (4a-4k) derivatives were synthesized and their anticancer potency were ... -
New triazole and triazolothiadiazine derivatives as possible antimicrobial agents
Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; Revıal, Gilbert (Elsevier France-Editions Scientifiques Medicales Elsevier, 2008)Triazole and triazoles fused with six-membered ring systems are found to possess diverse applications in the fields of medicine, agriculture and industry. The new 1,2,4-triazole and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine ... -
Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
Kaya, Betül; Yurttaş, Leyla; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2017)In the present study, a new series of 2-[4-(pyrimidin-2-yl) piperazin-1-yl]-2-oxoethyl 4-substituted piperazine- 1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory ...