Ara
Toplam kayıt 26, listelenen: 11-20
Synthesis and evaluation of new benzoxazole derivatives as potential antiglioma agents
(Marmara University, 2018)
Gliomas account for the majority of human brain tumors and the incidence of gliomas is expected to rise in upcoming years and therefore extensive efforts have been devoted to the discovery of potent antiglioma agents. Due ...
Apoptotic effects of dipyrido [3,2-a:2 ',3 '-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats
(Springer, 2014)
We evaluated the effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex ([Au(dppz)Cl-2]Cl) on apoptosis during chemically induced hepatocellular carcinoma. 48 male Spraque-Dawley rats were divided into six ...
A preliminary investigation of anticancer activity of novel benzothiazole derivatives against A549 lung carcinoma cell line
(Walter De Gruyter GMBH, 2017)
Objective(s): In this study, it was aimed to synthesize new chemotherapeutic agents based on known antiproliferative properties of benzothiazol-2-amine moiety. The antitumor activity of the newly synthesized compounds was ...
Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)
In the current work, new 1,3,4-oxadiazole derivatives were synthesized and investigated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cell lines. Compounds ...
Synthesis and anticancer activity of some novel benzothiazole-thiazolidine derivatives
(Taylor & Francis LTD, 2018)
Sixteen new 2-(benzothiazol-2-ylthio)-N-(3-substituted-4-(3,4-substitutedphenyl)thiazol-2(3H)-ylidene)acetohydrazide derivatives (4a-4p) were synthesized. The structures of the synthesized compounds were elucidated using ...
Synthesis and Evaluation of New Benzodioxole-Based Thiosemicarbazone Derivatives as Potential Antitumor Agents
(MDPI, 2016)
New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 mouse embryonic fibroblast cells. In order to ...
Synthesis and evaluation of naphthalene-based thiosemicarbazone derivatives as new anticancer agents against LNCaP prostate cancer cells
(Taylor & Francis LTD, 2016)
Fourteen new naphthalene-based thiosemicarbazone derivatives were designed as anticancer agents against LNCaP human prostate cancer cells and synthesized. MTT assay indicated that compounds 6, 8 and 11 exhibited inhibitory ...
Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
(MDPI, 2018)
During the last five decades, a large number of BT (Benzothiazole) derivatives formed one of the eligible structures in medicinal chemistry as anticancer agents. Most of the studies reveal that various substitutions at ...
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
(Elsevier Masson SAS, 2019)
Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. Based on ...
The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)
In search of potent and safe antifungal agents, herein, we report the synthesis, characterization and biological activities of triazole-oxadiazole compounds. The structural verification of the molecules was carried out by ...